Embelin-induced brain glioma cell apoptosis and cell cycle arrest via the mitochondrial pathway

Wang, Aiping; Zhang, Baochao; Zhang, Jiandang; Wu, Wei

doi:10.3892/or.2013.2369

Cited by 19 publications

(14 citation statements)

References 32 publications

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“…In another study, Feresin et al [ 21 ] determined higher MICs against both methicillin-sensitive and methicillin-resistant S. aureus strains at 62 and 250 μ g/mL, which can be explained by different strains used. However, embelin has been previously described for its synergistic antiproliferation interactions [ 22 – 24 ], but, according to our knowledge, this is the first report of its antimicrobial combinatory activity.…”

Section: Resultsmentioning

confidence: 97%

In VitroAntistaphylococcal Effects ofEmbelia schimperiExtracts and Their Component Embelin with Oxacillin and Tetracycline

Rondevaldova

Leuner

Teka

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Bacterial infections are in less-developed countries traditionally treated by remedies prepared from medicinal plants. Embelia schimperi (Vatke) is a plant used as a taenicide or disinfectant in Ethiopia, very often taken mixed with another plant species. In the present study, we examined two extracts prepared from seeds and twigs with leaves of E. schimperi and its main present secondary metabolite embelin for their antibacterial combinatory effect with oxacillin and tetracycline against sensitive and resistant Staphylococcus aureus strains. Minimum inhibitory concentrations were determined through the broth microdilution method, whereas the combinatory effect was evaluated through fractional inhibitory concentration sum (ΣFIC) indices. Results show many positive interactions and synergy occurring in embelin and oxacillin combinations against 4 out of 9 strains (ΣFIC 0.203–0.477) and for embelin and tetracycline combination against 3 out of 9 strains (ΣFIC 0.400–0.496). Moreover, the resistance to oxacillin has been overcome in 2 strains and to tetracycline in 3 strains. According to our knowledge, this is the first study showing antimicrobial combinatory effect of E. schimperi as well as of embelin. These findings can be used for the further research targeted on the development of new antistaphylococcal agents.

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Section: Resultsmentioning

confidence: 97%

In VitroAntistaphylococcal Effects ofEmbelia schimperiExtracts and Their Component Embelin with Oxacillin and Tetracycline

Rondevaldova

Leuner

Teka

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…In the present study, embelin treatment significantly suppressed cell proliferation, induced caspase-3 activation, and increased cell and nuclear apoptosis in the SGC7901 cells. Marsh et al (16) suggested that embelin suppresses the growth of pancreatic cancer in A549 non-small cell lung cancer (17) and brain glioma cells (18). Embelin is considered to be a potential drug for the treatment of carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Embelin induces apoptosis of human gastric carcinoma through inhibition of p38 MAPK and NF-κB signaling pathways

Zheng

Pei

et al. 2016

Molecular Medicine Reports

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Embelin is a small-molecule inhibitor of X‑linked inhibitor of apoptosis protein (XIAP), and it induces apoptosis in tumor cells via the inhibition of XIAP. The aim of the present study was to investigate the anticancer effect of embelin on human gastric carcinoma cells and the mechanisms underlying this effect. Cell proliferation of SGC7901 human gastric carcinoma cells was measured using MTT assay, following treatment with embelin (5, 10 and 15 µM) on days 1, 3 and 5. Caspase‑3 and nuclear factor (NF)‑κB p65 activation in SGC7901 cells were assessed using commercial kits. Cellular and nuclear apoptosis were analyzed with an Annexin V‑FITC/PI Apoptosis Detection kit and DAPI staining assay, respectively. Phospho (p)‑p38 mitogen‑activated protein kinase (MAPK), p‑inhibitor of NF‑κB (p‑IκBα) and p‑IκB kinase α/β (p‑IKKα/β) protein expression levels were analyzed with western blot assay. In the present study, treatment with embelin decreased cell proliferation, induced caspase‑3 activation and suppressed NF‑κB p65 activation in SGC7901 cells. Furthermore, embelin administration reduced p‑IκBα and p‑IKKα/β protein expression levels. In conclusion, embelin induces cell apoptosis in human gastric carcinoma through activation of p38 MAPK and inhibition of the NF‑κB signaling pathways. It was further suggested that embelin may be used as a potential drug for the treatment of gastric carcinoma.

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“…In brain glioma cells, embelin induced apoptosis and G0/G1-phase cell-cycle arrest. In addition, it modulated the shifting of Bcl-2 and Bax to prompt the mitochondrial release of cytochrome c, thereby activating the caspase proteins to induce apoptosis [ 59 ]. Furthermore, embelin induced the expression and oligomerization of voltage-dependent anion channel 1, situated in the outer mitochondrial membrane, which can function as a significant part of the permeability-transition pore that could promote cytochrome c as well as apoptosis-inducing factor release [ 60 ].…”

Section: Apoptosis-pathway Induction By Embelin In Cancermentioning

confidence: 99%

The Application of Embelin for Cancer Prevention and Therapy

Lee

Yang

et al. 2018

Molecules

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Embelin is a naturally-occurring benzoquinone compound that has been shown to possess many biological properties relevant to human cancer prevention and treatment, and increasing evidence indicates that embelin may modulate various characteristic hallmarks of tumor cells. This review summarizes the information related to the various oncogenic pathways that mediate embelin-induced cell death in multiple cancer cells. The mechanisms of the action of embelin are numerous, and most of them induce apoptotic cell death that may be intrinsic or extrinsic, and modulate the NF-κB, p53, PI3K/AKT, and STAT3 signaling pathways. Embelin also induces autophagy in cancer cells; however, these autophagic cell-death mechanisms of embelin have been less reported than the apoptotic ones. Recently, several autophagy-inducing agents have been used in the treatment of different human cancers, although they require further exploration before being transferred from the bench to the clinic. Therefore, embelin could be used as a potential agent for cancer therapy.

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Embelin-induced brain glioma cell apoptosis and cell cycle arrest via the mitochondrial pathway

Cited by 19 publications

References 32 publications

In VitroAntistaphylococcal Effects ofEmbelia schimperiExtracts and Their Component Embelin with Oxacillin and Tetracycline

In VitroAntistaphylococcal Effects ofEmbelia schimperiExtracts and Their Component Embelin with Oxacillin and Tetracycline

Embelin induces apoptosis of human gastric carcinoma through inhibition of p38 MAPK and NF-κB signaling pathways

The Application of Embelin for Cancer Prevention and Therapy

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