Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats

Ansari, Aneesa; Shahriar, Md. Shahed Zaman; Hassan, Md. Mehedi; Das, Shukla Rani; Rokeya, Begum; Haque, Md. Anwarul; Haque, Md. Enamul; Biswas, Nirupam; Sarkar, Tama

doi:10.1016/s1995-7645(13)60185-6

Cited by 34 publications

(19 citation statements)

References 17 publications

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“…The EO fruit extract reduces blood sugar levels. 41 , 42 Thus, caution should be taken when using hypoglycemic medications, and patients taking insulin or drugs for diabetes need to be monitored closely. In addition, EO decreases serum lipid levels; hence, cholesterol- or triglyceride-lowering medications should be taken with caution.…”

Section: Discussionmentioning

confidence: 99%

A systematic review on the cardiovascular pharmacology of Emblica officinalis Gaertn.

Hashem-Dabaghian¹,

Ziaee²,

Ghaffari³

et al. 2018

J Cardiovasc Thorac Res

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Introduction: The Emblica officinalis (EO) fruit has traditionally been considered as a cardioactive medication and has demonstrated remarkable cardiovascular effects in the pharmacological literature. The present study systematically reviews EO’s potential for prevention and therapy of cardiovascular diseases (CVD). Methods: PubMed, ScienceDirect, Scopus, Proquest, Ebsco, Google, Google Scholar, Ovid, and Cochrane databases were searched from 1966 to 2017 for the English and non-English literature using the terms including the cognates of EO including amla, Emblic myrobalan, Emblica officinalis, Emblica pectinata , Indian gooseberry, and Phyllanthus emblica together with antioxidant, arrhythmia, cardioprotective, cardiotoxicity, heart disease, heart failure, hyperlipidemia, hypertension, myocardial dysfunction, and oxidative stress. The inclusion criteria were in vitro, animal, and clinical cardiovascular pharmacological studies conducted on EO and full-text accessibility. The exclusion criterion was studies in which a combination of EO and at least one other plant was investigated. The reference lists of the retrieved articles were also searched manually for additional eligible articles. The methodological quality of clinical trials was assessed by the Jadad scale, and animal studies were evaluated by the ARRIVE checklist. Results: Nineteen articles concerning the cardiovascular pharmacological effects of EO were included in this review. The plant has shown antiatherogenic, anticoagulant, hypolipidemic, antihypertensive, antioxidant, antiplatelet, and vasodilatory effects as well as lipid deposition inhibitory properties. Moreover, it prevents from doxorubicin and isoproterenol cardiotoxicity and myocardial ischemia/reperfusion injury, and improves vascular endothelial function in animal studies. Some high-quality clinical studies report the vasodilatory and myocardial antioxidant properties as well as anti-platelet aggregation effects of this plant. Conclusion: EO influences various cardiovascular risk-factors. However, there is not sufficient evidence to confirm the plant efficacy in preventing and treating CVD.

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Section: Discussionmentioning

confidence: 99%

A systematic review on the cardiovascular pharmacology of Emblica officinalis Gaertn.

Hashem-Dabaghian¹,

Ziaee²,

Ghaffari³

et al. 2018

J Cardiovasc Thorac Res

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“…Various parts of medicinal plants like leaves, roots, bark and fruit are used by Ayurvedic practitioners for different therapeutic effects as they are safe, economical, least adverse effects [9]. Literature reports that water-soluble [10] extract of Emblica officinalis has potent antioxidant activity and hypoglycemic activity [11]. Emblica officinalis Gaertn.…”

Section: Methodsmentioning

confidence: 99%

“…is also known as "Amla" traditionally, belonging to the family Euphorbiaceae [12]. It is one of the most important plants of Ayurveda and traditional Indian medicine [11]. Other reports indicate that marmelosin present in Aegle marmelos has antidiabetic activity [13][14][15][16].…”

Section: Methodsmentioning

confidence: 99%

“…The suspension of EOAM was prepared with 2% of gum acacia. The diabetic animals were further divided into five groups consisting 6 animals each as follows,(1) group 3, low dose (containing of EOFAE 250+AMLEAE 250 mg/kg bw), (2) group 4, high dose (containing of EOFAE 500+AMLEAE 500 mg/kg bw), (3) group 5, low dose with glibenclamide (low dose of each extract+glibenclamide5 mg/kg body weight), (4) group 6, high dose with glibenclamide (high dose of each extract+glibenclamide5 mg/kg body weight) and(5) group 7, treated with glibenclamide5 mg/kg body weight used as reference drug [11].…”

Section: Experimental Animal Grouping and Treatmentmentioning

confidence: 99%

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Effect Ofco-Administration of Emblica Officinalis and Aegle Marmelos Extracts for Antioxidant and Antidiabetic Activity

Jain

Jaiswal

2019

Int J Pharm Pharm Sci

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Objective: The objective of the present study was to develop an HPLC analytical method and to perform in vivo study of Emblica officinalis and Aegle marmelos extracts for antioxidant and antidiabetic activity. Methods: The phytochemical analyses, total phenolic content (TPC), TLC, DPPH assay were performed for freeze-dried Emblica officinalis fruits aqueous extract (EOFAE) and Aegle marmelos leaves ethyl acetate extract (AMLEAE). The active constituents present in both extracts were estimated by using HPLC system having Hibar® C18 column [250 x4.6 mm, 5 µm] and UV detector (264 nm). A gradient mobile phase (acetonitrile and water with 0.1% trifluoroacetic acid) was used at a flow rate of 0.8 ml/min. In vivo antioxidant, antidiabetic activity of both extracts was conducted on male albino Wistar rats for 21 d in streptozotocin-induced diabetic rats (42 rats; n=6). The antidiabetic activity was measured by blood glucose level and biochemical parameters i.e. total cholesterol, triglycerides and total protein. Oxidative stress was measured by antioxidant biomarkers i.e. SOD, GSH, lipid peroxidation by thiobarbituric acid reactive substances method on the liver of the experimental rat. Results: Tannins, saponins, carbohydrate, glycosides are found in EOFAE; coumarins and flavonoids are found in AMLEAE and quinones, phenols are present in both extracts. The values of TPC present in standard gallic acid, EOFAE and AMLEAE were found to be 485.7, 315.6, 300.7 mgGAE/g, respectively. Rf values obtained by TLC of EOFAE and AMLEAE were found to be 0.41 and 0.50, respectively. The values of % inhibition shown by EOFAE and AMLEAE in DPPH assay were found to be 97.8%±2 and 95.2%±2, respectively. The values of retention time of EOFAE and AMLEAE by HPLC analysis were found to be 4.59 and 5.28 min, respectively. Histopathological examination of the liver was revealed that low dose EOAM (containing of EOFAE 250+AMLEAE 250 mg/kg body weight) administered once a daily for 21 d showed significant activity (P˂0.001) with biochemical parameters and antioxidant biomarkers. Conclusion: The present study showed that the EOFAE and AMLEAE treated group III with (EOAM) low dose of 500 mg/kg body weight has potent antioxidant and antidiabetic activity.

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“…Phyllanthus emblica L. fruit is mainly grown in tropical and subtropical regions, and enriches in a variety of biologically active compounds such as flavonoids, polyphenols and vitamin C. Previous studies have shown that the extract of P. emblica fruit can improve blood pressure, fatty liver, nonalcoholic steatohepatitis, diabetes, inflammation, antioxidant, and cancer (Fugh-Berman, 2000;Nain et al, 2012;Muthuraman et al, 2011;Ansari et al, 2014;Zhao et al, 2015;Tung et al, 2018). However, the effect of P. emblica fruit on methylglyoxal-induced insulin resistance remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Effect of Phyllanthus emblica L. fruit on improving regulation of methylglyoxal-induced insulin resistance in 3T3-L1 cells

Chen¹,

Tung²,

Chen³

et al. 2018

Journal of Food Bioactives

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The increasing methylglyoxal (MG) level of body has been found in people with obesity and insulin resistance, resulting from their dietary style and abnormal metabolic functions. MG promotes inflammation, oxidative stress, glycation, and all of which are closely related to insulin resistance and chronic diseases. Phyllanthus emblica L. fruit has various bioactivities such as anti-inflammation, anti-diabetes, anti-nonalcoholic fatty liver, and anti-dyslipidemia. Therefore, this study was aimed to investigate the effects of water extract of P. emblica (WEPE) and its enriched compound, ellagic acid, on MG-induced inflammation, insulin resistance, and lipogenesis in 3T3-L1 cells. The results showed that MG activated the peroxisome proliferator activated receptor-gamma (PPARγ) and CCAAT/ enhancer-binding protein alpha (C/EBPα), which can increase adipogenesis in adipocytes. In addition, MG enhanced pro-inflammatory cytokine IL-6 protein expression and release through the activation of MAPK and NF-κB signaling pathway, as well as increasing the monocyte chemoattractant protein-1 expression to cause macrophage infiltration. MG also significantly reduced glucose uptake, indicating that insulin resistance in obese patients may be related to MG generation. WEPE and ellagic acid effectively decreased IL-6 protein expression and cytokine release through inactivation of JNK and p65 pathways. WEPE and ellagic acid significantly increased glucose uptake and reduced insulin resistance by MG treatment. WEPE also decreased the protein-tyrosine phosphatase 1B to reduce insulin resistance and inhibited MG-induced fat accumulation related proteins such as PPARγ, C/EBPα, FAS, and p-ACC. Therefore, WEPE may have the potential to ameliorate MG-induced inflammation, increase glucose uptake, and decrease fat accumulation.

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Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats

Abstract: The aqueous extract of E. officinalis has a promising antidiabetic and antioxidant properties and may be considered for further clinical studies in drug development.

Cited by 34 publications

References 17 publications

A systematic review on the cardiovascular pharmacology of Emblica officinalis Gaertn.

A systematic review on the cardiovascular pharmacology of Emblica officinalis Gaertn.

Effect Ofco-Administration of Emblica Officinalis and Aegle Marmelos Extracts for Antioxidant and Antidiabetic Activity

Effect of Phyllanthus emblica L. fruit on improving regulation of methylglyoxal-induced insulin resistance in 3T3-L1 cells

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