Embolization of cranial/spinal tumours and vascular malformations with hydrogel microspheres: An experience of 69 cases

Phadke, Rajendra V.; Venkatesh, Sudhakar K.; Kumar, Sunil; Tandon, Vini; Pandey, Rakesh; Tyagi, Isha; Vk, Jain; Chhabra, D. K.

doi:10.1080/028418502127347583

Cited by 6 publications

(6 citation statements)

References 11 publications

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“…Embolisation is performed with particles when hypervascular tumours with accessible arterial pedicles are diagnosed [ 26 ] . Percutaneous injections of liquid agents are generally only used for palliation.…”

Section: Other Craniofacial Tumoursmentioning

confidence: 99%

Head and Neck Vascular Lesions

Byrne

2011

Tutorials in Endovascular Neurosurgery and Interventional Neuroradiology

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Section: Other Craniofacial Tumoursmentioning

confidence: 99%

Head and Neck Vascular Lesions

Byrne

2011

Tutorials in Endovascular Neurosurgery and Interventional Neuroradiology

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“…PLGA is a biocompatible, synthetic polymer approved by the Food and Drug Administration 43,44 that does not contain biological byproducts or pathogens and is not recognized as an antigen or allergen. In addition to the aesthetic applications, PLGA microspheres could be used as an embolization agent 45 that geometrically blocks blood vessels to restrain or reduce tumor. After curing tumor by the treatment, there might be no concern of problems regarding the embolization agent remaining in the tissues, because PLGA is removed by degradation.…”

Section: Discussionmentioning

confidence: 99%

Poly(lactic‐co‐glycolic acid) microspheres as a potential bulking agent for urological injection therapy: Preliminary results

2004

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Injection of bulking substances has been introduced as a new therapy to treat urinary incontinence and vesicoureteral reflux. Currently available bulking substances for the injection therapies include liquid or particulated silicone, collagen gel, and polytetrafluoroethylene paste. However, these materials have shown shortcomings such as inflammation, rapid volume decrease, and particle migration to distant organs. In the present study, we evaluated poly(lactic-co-glycolic acid) (PLGA) microspheres as a potential injectable bulking agent for the injection therapies. PLGA microspheres (52 m in average diameter) were injectable through various gauges of needles, as the injected microspheres showed no tendency to obstruct the needles and microsphere size exclusion was not observed upon injection through the needles. After injection of PLGA microspheres into the subcutaneous dorsum of mice, inflammation, new tissue volume change, and microsphere migration were examined. Host cells from the surrounding tissues migrated to the implanted microspheres and formed new hybrid tissue structures. The volume of the newly generated tissues was maintained approximately constant for 7 weeks. Histological analyses showed no evidence of migration of the implanted microspheres to the distant organs. In summary, PLGA microspheres were injectable and able to induce a new hybrid tissue formation without initial volume decrease or particle migration. These preliminary results suggest that this material may be a potentially useful bulking agent for urological injection therapies.

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“…In 2001, PMMA started being applied to gastro‐oesophageal reflux therapy through implant in the oesophageal submucosa via trans‐oral endoscopy 21–24 . It is also used in the correction of body deformities, in intraocular lens, in preventive haemostasis and in urinary bladder dysfunction 20,25,37–44 .…”

Section: Introductionmentioning

confidence: 99%

Use of polymethylmethacrylate as permanent filling agent in the jaw, mouth and face regions – implications for dental practice

et al. 2011

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Use of polymethylmethacrylate as permanent filling agent in the jaw, mouth and face regionsimplications for dental practiceObjectives: This article is a review of PMMA focusing on its properties, indications, contra-indications and adverse effects. Background: The search to remain young is a constant attitude among Brazilians. The low cost of filling agents have stimulated its indiscriminate use, especially the bioplasty (non-incisional method). Polymethylmethacrylate (PMMA) is the cosmetic filling agent of choice, because of its low cost, easy access and simple application technique. The impact on dentistry and orofacial medicine needs further awareness. Conclusion: The article aims to draw the attention of odontology and medical professionals to the product's applicability and its possible complications.

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Embolization of cranial/spinal tumours and vascular malformations with hydrogel microspheres: An experience of 69 cases

Abstract: HMs are highly suitable as embolization agents in the management of craniofacial and spinal hypervascular lesions.

Cited by 6 publications

References 11 publications

Head and Neck Vascular Lesions

Head and Neck Vascular Lesions

Poly(lactic‐co‐glycolic acid) microspheres as a potential bulking agent for urological injection therapy: Preliminary results

Use of polymethylmethacrylate as permanent filling agent in the jaw, mouth and face regions – implications for dental practice

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