Embroidered and surface coated polycaprolactone-co-lactide scaffolds

Rentsch, Barbe; Bernhardt, Ricardo; Scharnweber, Dieter; Schneiders, Wolfgang; Rammelt, Stefan; Rentsch, Claudia

doi:10.4161/biom.21931

Cited by 31 publications

(34 citation statements)

References 42 publications

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“…Synthetic Organic Materials : Synthetic organic materials are often made from polymers like polycaprolactone (PCL), poly(ethylene glycol) (PEG), and poly(vinyl alcohol) to name a few ( Figure ). These scaffolds can be synthesized with controlled physical and chemical properties to meet specific applications and are typically highly reproducible and simple to manufacture .…”

Section: Scaffold Biomaterials For 3d Culture Of Stem Cellsmentioning

confidence: 99%

Looking into the Future: Toward Advanced 3D Biomaterials for Stem‐Cell‐Based Regenerative Medicine

et al. 2018

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Stem-cell-based therapies have the potential to provide novel solutions for the treatment of a variety of diseases, but the main obstacles to such therapies lie in the uncontrolled differentiation and functional engraftment of implanted tissues. The physicochemical microenvironment controls the self-renewal and differentiation of stem cells, and the key step in mimicking the stem cell microenvironment is to construct a more physiologically relevant 3D culture system. Material-based 3D assemblies of stem cells facilitate the cellular interactions that promote morphogenesis and tissue organization in a similar manner to that which occurs during embryogenesis. Both natural and artificial materials can be used to create 3D scaffolds, and synthetic organic and inorganic porous materials are the two main kinds of artificial materials. Nanotechnology provides new opportunities to design novel advanced materials with special physicochemical properties for 3D stem cell culture and transplantation. Herein, the advances and advantages of 3D scaffold materials, especially with respect to stem-cell-based therapies, are first outlined. Second, the stem cell biology in 3D scaffold materials is reviewed. Third, the progress and basic principles of developing 3D scaffold materials for clinical applications in tissue engineering and regenerative medicine are reviewed.

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Section: Scaffold Biomaterials For 3d Culture Of Stem Cellsmentioning

confidence: 99%

Looking into the Future: Toward Advanced 3D Biomaterials for Stem‐Cell‐Based Regenerative Medicine

et al. 2018

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“…For example, when evaluating some bioactive active agents (e.g., growth factors such as bone morphogenetic proteins [BMPs]), large speciesspecific variations in efficacy and dose responsiveness may be present. [20][21][22][23][24][25][26][27][28][29][30][31] As a result, preclinical assessment in this setting can be complicated by the need to identify and utilize an animal species in which responsiveness is comparable to humans or to utilize a species-specific formulation that is modified to create an effect that is comparable in the model being used to the bioactivity expected in the clinical setting. In the setting where allograft tissue-derived materials are being assessed, immunological barriers make implantation of human tissues into animal subjects (a xenograft) an inappropriate model.…”

Section: Domains Of Use For Animal Modelsmentioning

confidence: 99%

The Design and Use of Animal Models for Translational Research in Bone Tissue Engineering and Regenerative Medicine

Muschler

Raut

Patterson

et al. 2010

Tissue Engineering Part B: Reviews

268

256

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This review provides an overview of animal models for the evaluation, comparison, and systematic optimization of tissue engineering and regenerative medicine strategies related to bone tissue. This review includes an overview of major factors that influence the rational design and selection of an animal model. A comparison is provided of the 10 mammalian species that are most commonly used in bone research, and existing guidelines and standards are discussed. This review also identifies gaps in the availability of animal models: (1) the need for assessment of the predictive value of preclinical models for relative clinical efficacy, (2) the need for models that more effectively mimic the wound healing environment and mass transport conditions in the most challenging clinical settings (e.g., bone repair involving large bone and soft tissue defects and sites of prior surgery), and (3) the need for models that allow more effective measurement and detection of cell trafficking events and ultimate cell fate during the processes of bone modeling, remodeling, and regeneration. The ongoing need for both continued innovation and refinement in animal model systems, and the need and value of more effective standardization are reinforced.

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“…The cells get embedded in their own tissue-like matrix, and the material of the artificial structure degrades, leaving a naturally produced bone tissue in place (Rentsch et al, 2012). The artificial matrix is arranged as a three-dimensional porous structure.…”

Section: Regeneration Of Critical Size Defects By Tissue Engineeringmentioning

confidence: 99%

Embroidery technology for hard-tissue scaffolds

Breier

2015

Biomedical Textiles for Orthopaedic and Surgical Applications

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Embroidered and surface coated polycaprolactone-co-lactide scaffolds

Cited by 31 publications

References 42 publications

Looking into the Future: Toward Advanced 3D Biomaterials for Stem‐Cell‐Based Regenerative Medicine

Looking into the Future: Toward Advanced 3D Biomaterials for Stem‐Cell‐Based Regenerative Medicine

The Design and Use of Animal Models for Translational Research in Bone Tissue Engineering and Regenerative Medicine

Embroidery technology for hard-tissue scaffolds

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