Embryological stages in the establishing of myeloschisis with spina bifida

Patten, Bradley M.

doi:10.1002/aja.1000930304

Cited by 169 publications

(56 citation statements)

References 20 publications

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“…The debate about the best time to perform the MMC surgical repair reappeared alongside pathological observations, experimental models and initial experiences of intrauterine surgeries [2,21,22,23,24,25]. Since 1997, the number of experimental studies has been increasing and there is a growing body of clinical experience in fetal surgery in the United States [2, 6, 26].…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Myelomeningocele Carried Out at ‘Time Zero’ Immediately after Birth

Pinto¹,

Matushita²,

Furlan³

et al. 2009

Pediatr Neurosurg

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Background/Aims: To present a protocol of immediate surgical repair of myelomeningocele (MMC) after birth (‘time zero’) and compare this surgical outcome with the surgery performed after the newborn’s admission to the nursery before the operation. Methods: Data from the medical files of 31 patients with MMC that underwent surgery after birth and after admission at the nursery (group I) were compared with a group of 23 patients with MMC admitted and prospectively followed, who underwent surgery immediately after birth – ‘at time zero’ (group II). Results: The preoperative rupture of the MMC occurred more frequently in group I (67 vs. 39%, p < 0.05). The need for ventriculoperitoneal shunt was 84% in group I and 65% in group II and 4 of them were performed during the same anesthetic time as the immediate MMC repair, with no statistically significant difference. Group I had a higher incidence of small dehiscences when compared to group II (29 vs. 13%, p < 0.05); however, there was no statistically significant difference regarding infections. After 1 year of follow-up, 61% of group I showed neurodevelopmental delay, whereas only 35% of group II showed it. Conclusions: The surgical intervention carried out immediately after the birth showed benefits regarding a lower incidence of preoperative rupture of the MMC, postoperative dehiscences and lower incidence of neurodevelopmental delay 1 year after birth.

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Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Myelomeningocele Carried Out at ‘Time Zero’ Immediately after Birth

Pinto¹,

Matushita²,

Furlan³

et al. 2009

Pediatr Neurosurg

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“…Выраженная анэнцефалия, по мнению авторов, была обусловлена несмыканием нервных валиков, хотя другие исследователи, обнаружив открытую нервную трубку у эмбриона человека на той же стадии развития, не зафиксировали каких-либо аномалий [22]. Этим результатам противоречит описание случая с миело-менингоцеле, которое локализовалось в районе открытой нервной трубки [23]. Следует отметить, что в нашей работе была проведена оценка количества нервной ткани по срав-нению с таковым у нормальных зародышей [15,24,25].…”

Section: исследования ранних эмбриональных нарушений развития человекаunclassified

The Early Embryonal Anomalies of Human Brain

2012

Annals RAMS

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“…It has been thought that a primary disorder of neurulation with a failure of neural plate closing contributes to SBA [2]. In early human fetuses with SBA and a mouse SBA model, the neural plate differentiates normally except for neurulation [6,16,17]. However, the pathological mechanism of the motor complications associated with SBA remains unclear.…”

mentioning

confidence: 99%

Developmental Delay in Islet-1-Positive Motor Neurons in Chick Spina Bifida

Wang

Mominoki

Kinutani

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Spina bifida aperta (SBA) is a congenital malformation of the spinal cord with complications such as spinal ataxia and bowel and bladder dysfunction. We have developed a chick model with surgery-induced SBA that shows spinal ataxia after hatching. In the present study, motor neurons in the early stages in chicks with and without SBA were observed by immunohistochemical staining with a monoclonal antibody against Islet-1, a motor neuron marker. Delay in migration and maturation of motor neurons was observed in SBA. Although the final numbers of Islet-1-positive neurons in these two groups were not different, a defect in the production and elimination of excess motor neurons in the early developmental stages in the SBA group may be involved in the pathological mechanism of the motor complications of this disease.KEY WORDS: animal model for human disease, chick, motor neurons, neural cell differentiation, Spina bifida aperta.

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Embryological stages in the establishing of myeloschisis with spina bifida

Cited by 169 publications

References 20 publications

Surgical Treatment of Myelomeningocele Carried Out at ‘Time Zero’ Immediately after Birth

Surgical Treatment of Myelomeningocele Carried Out at ‘Time Zero’ Immediately after Birth

The Early Embryonal Anomalies of Human Brain

Developmental Delay in Islet-1-Positive Motor Neurons in Chick Spina Bifida

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