Patients with cholelithiasis are treated by the method of extracorporeal lithotripsy. The technique of the combined use of two lithotriptors with different modes of shock wave generation (electrohydraulic and electromagnetic) is described. As a result of treatment the number of skin petechiae decreases as do transitory hematuria and manifestations of hepatic colic and acute panereatitis, whereas mechanical jaundice and acute cholecystitis develop with the same frequency. The number of recurrences of cholelithogeny in patients with hyperlipidemia is 8 times higher than in the control, which indicates a clear connection between hyperlipidernia and stone formation in patients after extracorporeal biliary lithotripsy. Key Words: cholelithiasis; extracorporeal biliary lithotripsy; hyperlipoproteinemiaExtracorporeal biliary lithotripsy (ECBL) has proven to be a rather effective and sparing treatment of cholelithiasis. We showed that ECBL is the treatment of choice for some 15% of patients with gallstones. Successful treatment with ECBL depends on a careful choice of patients who are to undergo the procedure. Candidates were chosen on the basis of ultrasound scanning as well as findings of peroral cholecystography in addition to a general clinical examination. This allowed us to work out clear guidelines for selecting patients to undergo ECBL.We used two lithotriptors with different modes of generation of shock waves (electrohydraulic and electromagnetic) to achieve a favorable combination of these apparatuses, which are considered comparable in terms of the intensity of the shock wave [4,7,10,11]. It was noted, however, that the Sonolith 3000 possesses a more powerful destructive ability.Analysis of the long-term results of the treatment revealed that new stones form in 23% of pa-

Using gas chromatography a comparative study of the range and content of individual non-esterified fatty acids in serum of patients with diabetes mellitus type 1 in the third trimester of pregnancy, and healthy pregnant and non-pregnant women has been carried out. In groups of pregnant women there was activation of lipid metabolism, confirmed by corresponding changesinserum biochemical parameters, as well as in the content of non-esterified fatty acids. Intergroup differences in the non-esterified fatty acids were not found. However, there were significant differences between the examined groups in the quantitative content of non-esterified fatty acids.

Complete profiles of phospholipid and ceramide molecular species from erythrocyte lipid extracts of children without carbohydrate metabolism disorders, and children with type 1 diabetes were compared by means of high performance liquid chromatography/mass spectrometry. For the first time a statistically significant increase (p<0.05) of lysophosphatidylcholine content in two groups of diabetic children with different duration of the disease (less than one year and more than one year) was found. Statistically significant changes in other lipid classes were not observed. The dependence of the content of phosphatidylcholine and phosphatidylethanolamine molecular species containing arachidonic acid residue (20:4) on the duration of the disease was found. The observed shift in lipid metabolism suggests of phospholipase A2 and chronic inflammatory process at different stages of diabetes mellitus, in cells (erythrocytes), which aer not involved in the immune response.