Embryonic dysplasia and adult retinal dystrophy in boron-deficient zebrafish

Eckhert, Curtis D.; Rowe, Ruby I.

doi:10.1002/(sici)1520-670x(1999)12:3<213::aid-jtra5>3.0.co;2-0

Cited by 40 publications

(19 citation statements)

References 14 publications

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“…This dependent variable was not statistically affected by supplemental B, and this could be attributed to the small sample size. Boron supplementation to low B culture conditions stimulated embryonic trout growth (Eckhert, 1998), and increased survivability of zebrafish embryos (Eckhert and Rowe, 1999;Rowe and Eckhert, 1999). In addition, Xenopus laevis embryos derived from low-B parents had an increase in necrosis, mortality, and malformation frequencies (Fort et al, 1999).…”

Section: Resultsmentioning

confidence: 99%

Long-term effects of boron supplementation on reproductive characteristics and bone mechanical properties in gilts

Armstrong

Flowers

Spears

et al. 2002

Journal of Animal Science

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An experiment was conducted to determine long-term effects of dietary boron (B) on reproductive and bone characteristics in gilts. Weanling gilts (n = 50) were allotted to 10 pens based on weaning weight and litter origin. Pens were randomly assigned to receive one of two dietary treatments that consisted of a basal diet low in B (control) and the basal diet supplemented with 5 mg of B/kg diet as sodium borate. Gilts remained on their respective experimental diets throughout the nursery phase, growing-finishing phase, sexual maturity, breeding, gestation, and lactation. The day of first observed standing estrus was defined as puberty, and each pubertal gilt was bred via AI at the second observed standing estrus. Eight randomly selected gilts per treatment were slaughtered at d 35 of gestation for the assessment of embryonic and reproductive characteristics, bone characteristics, and tissue B concentrations. The remaining pregnant gilts (control, n = 11; 5 mg supplemental B/kg diet, n = 10) farrowed, and litter characteristics at farrowing and weaning were determined. Age at puberty was not affected (P = 0.72) by B, and neither were the number of corpora lutea on the ovaries (P = 0.44) or the total number of embryos (P = 0.95) at d 35 of gestation. Boron supplementation increased (P = 0.05) pig weaning weight and tended (P = 0.11) to increase pig birth weight; however, no other litter characteristics were affected (P > 0.12) by B. Extrinsic and intrinsic strength measures of bone were increased (P < 0.09) by B. Fat-free bone ash percentage and bone mineral concentrations were not affected (P > or = 0.19) by dietary B. Supplemental B increased (P < or = 0.06) the B concentrations of the muscle, liver, and reproductive tissues. Serum osteocalcin concentrations tended (P = 0.13) to be increased by dietary B, which may be related to increased bone turnover in B-supplemented gilts. Results indicate that B may have beneficial effects upon reproductive and bone characteristics.

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Section: Resultsmentioning

confidence: 99%

Long-term effects of boron supplementation on reproductive characteristics and bone mechanical properties in gilts

Armstrong

Flowers

Spears

et al. 2002

Journal of Animal Science

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“…A role for B in membranes is also supported by findings that B deficiency in animals primarily disrupts processes that are highly membrane specific or that require synthesis of new membranes. Boron has been shown to be essential for the highly membrane dependent process of embryogenesis in zebrafish (Eckhert and Rowe, 1999 [33] ). Boron deficiency during the embryonic period was seen as dysplasia during the zygote and cleavage periods.…”

Section: The Role Of Boron In Membrane Structure and Functionmentioning

confidence: 99%

“…A role for B in membranes is also supported by findings that B deficiency in animals primarily disrupts processes that are highly membrane specific or that require synthesis of new membranes. In both the African clawed frog (Xenopus laevis) (Fort et al, 1998 [41] ) and the zebrafish (Eckhert and Rowe, 1999 [33] ) B is essential for the normal reproduction while in mature zebrafish, B deficiency results in dystrophy of photoreceptors in the eye (Eckhert and Rowe, 1999 [33] ). These processes are characterized by a high requirement for membrane synthesis.…”

Section: Introductionmentioning

confidence: 99%

“…Evidence that B has a biological role in other organisms was first indicated by the establishment of essentiality of B for diatoms (Smyth and Dugger, 1981 [138] ) and cyanobacteria (Bonilla et al, 1990 [14] ; Garcia-Gonzalez et al, 1991 [44] ; Bonilla et al, 1997 [16] ). Recently, B was shown to stimulate growth in yeast (Bennett et al, 1999 [8] ) and to be essential for zebrafish (Danio rerio) (Eckhert and Rowe, 1999 [33] ; Rowe and Eckhert, 1999 [121] ) and possibly for trout (Oncorhynchus mykiss) (Eckhert, 1998 [32] ; Rowe et al, 1998 [120] ), frogs (Xenopus laevis) (Fort et al, 1998 [41] ) and mouse (Lanoue et al, 2000 [75] ). There is also preliminary evidence to suggest that B has at least a beneficial role in humans (Nielsen, 2000 [96] ).…”

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Boron in Plant Biology

et al. 2002

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The interest of biologists in boron (B) has largely been focused on its role in plants for which B was established as essential in 1923 (Warington, 1923[296]). Evidence that B has a biological role in other organisms was first indicated by the establishment of essentiality of B for diatoms (Smyth and Dugger, 1981[296]) and cyanobacteria (Bonilla et al., 1990[296]; Garcia‐Gonzalez et al., 1991[296]; Bonilla et al., 1997[296]). Recently, B was shown to stimulate growth in yeast (Bennett et al., 1999[296]) and to be essential for zebrafish (Danio rerio) (Eckhert and Rowe, 1999[296]; Rowe and Eckhert, 1999[296]) and possibly for trout (Oncorhynchus mykiss) (Eckhert, 1998[296]; Rowe et al., 1998[296]), frogs (Xenopus laevis) (Fort et al., 1998[296]) and mouse (Lanoue et al., 2000[296]). There is also preliminary evidence to suggest that B has at least a beneficial role in humans (Nielsen, 2000[296]). While research into the role of B in plants has been ongoing for 80 years it has only been in the past 5 years that the first function of B in plants has been defined. Boron is now known to be essential for cell wall structure and function, likely through its role as a stabilizer of the cell wall pectic network and subsequent regulation of cell wall pore size. A role for B in plant cell walls, however, is inadequate to explain all of the effects of B deficiency seen in plants. The suggestion that B plays a broader role in biology is supported by the discovery that B is essential for animals where a cellulose‐rich cell wall is not present. Careful consideration of the physical and chemical properties of B in biological systems, and of the experimental data from both plants and animals suggests that B plays a critical role in membrane structure and hence function. Verification of B association with membranes would represent an important advance in modern biology. For several decades there has been uncertainty as to the mechanisms of B uptake and transport within plants. This uncertainty has been driven by a lack of adequate methodology to measure membrane fluxes of B at physiologically relevant concentrations. Recent experimentation provides the first direct measurement of membrane permeability of B and illustrates that passive B permeation contributes sufficient B at adequate levels of B supply, but would be inadequate at conditions of marginal B supply. The hypothesis that an active, carrier mediated process is involved in B uptake at low B supply is supported by research demonstrating that B uptake can be stimulated by B deprivation, that uptake rates follow a Michaelis‐Menton kinetics, and can be inhibited by application of metabolic inhibitors. Since the mechanisms of element uptake are generally conserved between species, an understanding of the processes of B uptake is relevant to studies in both plants and animals. The study of B in plant biology has progressed markedly in the last decade and we are clearly on the cusp of additional, significant discoveries. Research in this field will be greatly stimulat...

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“…Dietary boron intakes have been shown to alter human steroid hormone levels (5). Diets deplete in the element has been shown to affect both the immune and nervous systems (24)(25)(26). To date, no epidemiologic studies have been conducted to investigate whether excessive or insufficient dietary boron intake is related to the development of diseases.…”

Section: Introductionmentioning

confidence: 99%

Dietary boron intake and prostate cancer risk

Cui

Winton²,

Zhang³

et al. 2004

Oncol Rep

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Boron affects human steroid hormone levels. Circulating testosterone and estradiol levels have been proposed to modify prostate cancer risk. However, the association between dietary boron intake and the risk of prostate cancer has not been evaluated by any epidemiological study. We explored the association between dietary boron intake and the risk of prostate cancer in the USA. Our analysis was based on data from the third National Health and Nutrition Examination Survey (NHANES III). Crosssectional case-control study design was employed by comparing boron intake of 95 prostate cancer cases with that of 8,720 male controls. After controlling for age, race, education, smoking, body mass index, dietary caloric intake, and alcohol consumption, increased dietary boron intake was associated with a decreased risk of prostate cancer with a doseresponse pattern. The adjusted odds ratio was 0.46 (95% confidence interval: 0.21-0.98) for the highest quartile of boron intake comparing to the lowest quartile (P for trend = 0.0525). The observed association should be interpreted with caution because of the small case sample size and the nature of the cross-sectional study design, but deserve further investigation.

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Embryonic dysplasia and adult retinal dystrophy in boron-deficient zebrafish

Cited by 40 publications

References 14 publications

Long-term effects of boron supplementation on reproductive characteristics and bone mechanical properties in gilts

Long-term effects of boron supplementation on reproductive characteristics and bone mechanical properties in gilts

Boron in Plant Biology

Dietary boron intake and prostate cancer risk

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