Embryotoxic and Teratogenic Potentials of Salacia lehmbachii in Rats

Prenatal developmental toxicity study of herbal tea of Moringa stenopetala and Mentha spicata leaves formulation in Wistar rats

“…These results indicate that the administration of herbal tea could not induce in-life adverse effects in pregnant rats. The present maternal in-life findings are in agreement with earlier toxicity studies of extracts of Mentha piperita leaves [50] , Salacia lehmbachii root [52] , and Achyranthes aspera leaves [39] , which asserted that the prenatal oral administration of different doses of the extracts did not produce in-life adverse effects (i.e., mortality, morbidity, loss of body weight, or loss of food intake) in pregnant rats.…”

“…These maternal systemic toxicity findings indicate that the prenatal oral administration of herbal tea of M. stenopetala and M. spicata leaves may not induce significant effects on the serum biochemistry and gross necropsy of pregnant rats at the studied dose levels. Similar results were observed with previous prenatal developmental toxicity studies of extracts of Orthosiphon stamineus leaves [53] , Parkia platycephala leaves [54] , and Salacia lehmbachii root [52] , which revealed that oral administration of the extracts at different doses during the days 5–19 of gestation produced no significant systemic toxicity effects in rats.…”

“…Furthermore, all study groups' maternal reproductive data were within the historical control reference ranges for rats [56] , [57] . These maternal reproductive findings were consistent with earlier prenatal developmental toxicity studies conducted with Bulbine natalensis stem extract in rats [58] , Mentha piperita leaf extract in mice [50] , Salacia lehmbachii root extract in rats [52] , and Ginkgo biloba herbal extract in rats [59] .…”

RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

“…Before the start of the experiment, tested animals were acclimatized for one week to normal laboratory conditions (temperature: 22 ± 2 C, relative humidity: 50 ± 5% with 12 h of the light-dark cycle. They were maintained at the same conditions throughout the study period following the guidelines on Care and Use of Laboratory animals [15]. All methods were performed in accordance with the relevant guidelines and regulations and compliance with ARRIVE guidelines for the care and use of experimental animals by the committee for supervision of Experiment on animals (CPCSEA) and the National Institute of Health NIH Protocol [36].…”

Evaluation of The Toxicity of Scorpion Venom and Digoxin on Human Cardiovascular System and in Decomposition Arthropods Succession Using Rat Carrions

“…Before the start of the experiment, tested animals were acclimatized for one week to normal laboratory conditions (temperature: 28±20C, relative humidity: 50±5 % with 12 hours of the light-dark cycle). They were maintained at the same conditions throughout the study period according to the guidelines on Care and Use of Laboratory animals (Essiet et al, 2017). The studied rats were divided into three groups (five rats in each group).…”