Emergence of CTX-M-15-producing Klebsiella pneumoniae of multilocus sequence types 1, 11, 14, 17, 20, 35 and 36 as pathogens and colonizers in newborns and adults

Abstract

This study shows that multiresistant K. pneumoniae producing CTX-M-15 of MLST types 1, 11, 14, 17, 20, 35 and 36 are spreading as pathogens and colonizers among newborns and adult patients in Spain.

OXA-163-Producing Klebsiella pneumoniae in Cairo, Egypt, in 2009 and 2010

“…This rules out the clonal expansion of an OXA-163-producing strain in Egypt and, alternatively, supports the hypothesis of horizontal transmission of this genetic determinant via plasmids, according with the previous report (14). Notably, strains belonging to ST20 and ST37 have been previously identified in different countries as ESBL or carbapenemase producers (11,12). Moreover, it is of special interest that OXA-163 has been identified in Egypt, a country of North Africa, a geographical area where OXA-48-producing Gram negatives are considered endemic (6, 9, 10).…”

Plasmid-Mediated Quinolone Resistance

“…Association with ESBL CTX-M-15 is particularly common (110,(184)(185)(186)(187)(188)(189)(190). A mobile genetic element, especially IS26, is often associated (191).…”

A Swordless Knight: Epidemiology and Molecular Characteristics of the bla KPC -Negative Sequence Type 258 Klebsiella pneumoniae Clone

“…The molecular mechanisms behind the success of the KPC-producing ST-258 clone have remained obscure. An intriguing finding in this regard is that to date, carbapenem-susceptible ST-258 has never been reported in the literature as associated with any particular factor involved with either virulence or epidemiological success (7,15,39,46). In June 2010, the National Center for Infection Control (NCIC) in Israel received a report concerning a high incidence of ertapenem-resistant, carbapenemase-negative K. pneumoniae (ERCNKP) infections at the Laniado Medical Center (LMC).…”