Emergence of <i>mcr-</i>1 Producing <i>Salmonella enterica</i> serovar Typhimurium from Retail Meat: First Detection in Brazil

Rau, Renata Batista; Lima-Morales, Daiana de; Wink, Priscila Lamb; Ribeiro, A. R.; Martins, Andreza Francisco; Barth, Afonso Luís

doi:10.1089/fpd.2017.2346

Cited by 30 publications

(16 citation statements)

References 8 publications

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“…Moreover, three analyzed Salmonella WGS showed mcr genes (one WGS showed mcr-1.1 and the other two showed mcr-9). The announcement of the first report of mcr genes in Salmonella from Brazil has been recently published (Rau et al, 2018;Moreno et al, 2019) and highlights the intercontinental spread of this plasmidial gene. Currently, colistin is not the first choice to treat human infections caused by Salmonella, and the development of clinical colistin resistance is apparently non-relevant.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Antimicrobial Resistance Genes in Salmonella From Brazil by in silico Whole-Genome Sequencing Analysis: An Overview of the Last Four Decades

et al. 2020

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Rodrigues et al. AMR Salmonella From Brazil frequency rates of antimicrobial resistance genes and predicted resistance phenotypes in the 2000s and the 2010s when compared with the 1980s and 1990s. The results presented herein contributed significantly to the understanding of the strategic use of WGS associated with in silico analysis and the predictions for the determination of AMR in Salmonella from Brazil.

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Section: Discussionmentioning

confidence: 99%

Frequency of Antimicrobial Resistance Genes in Salmonella From Brazil by in silico Whole-Genome Sequencing Analysis: An Overview of the Last Four Decades

et al. 2020

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“…There have been many reports of MCR producers in Brazil, with MCR-1 being the only variant systematically identified. These isolates were a single Salmonella enterica serotype Typhimurium isolate that was recovered from retail meat (18) and E. coli isolates recovered from chicken meat (19), from migratory penguins (20), on public beaches (21), or from patients with bloodstream infections (22,23). Also, KPC-2-producing E. coli isolates (24) and KPC-2-producing Klebsiella pneumoniae isolates belonging to ST392 and ST437 (25,26) were identified.…”

Section: Discussionmentioning

confidence: 99%

Genetic and Functional Characterization of an MCR-3-Like Enzyme-Producing Escherichia coli Isolate Recovered from Swine in Brazil

Kieffer

Nordmann

Moreno

et al. 2018

Antimicrob Agents Chemother

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A collection of 126 pigs was screened for carriage of colistin-resistant in a farm in Minas Gerais, Brazil. Out of this collection, eight colistin-resistant isolates were recovered, including one from Minas Gerais State producing a new MCR-3 variant (MCR-3.12). Analysis of the lipopolysaccharide revealed that MCR-3.12 had a function similar to that of MCR-1 and MCR-2 as a result of the addition of a phosphoethanolamine group to the lipid A moiety. Genetic analysis showed that the gene was carried by an IncA/C plasmid and was embedded in an original genetic environment. This study reports the occurrence of the MCR-3-like determinant in South America and is the first to demonstrate the functionality of this group of enzymes as a phosphoethanolamine transferase.

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“…Regarding food samples, mcr-1 was detected in E. coli obtained from chicken meat samples acquired in retail markets in São Paulo State (SE), and from three of 409 chicken carcasses produced in the three Southern states, most of them in isolates carrying β-lactamase genes [149,169]. The gene has also been reported in S. Typhimurium, and S. Schwarkergund collected from pork meat, and poultry meat acquired in the Rio Grande do Sul (S) and São Paulo (SE) States, respectively [95,170].…”

Section: Colistin Resistance-mcrmentioning

confidence: 99%

Antimicrobial Resistance in Farm Animals in Brazil: An Update Overview

Rabello

Bonelli

Penna

et al. 2020

Animals

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In animal husbandry, antimicrobial agents have been administered as supplements to increase production over the last 60 years. Large-scale animal production has increased the importance of antibiotic management because it may favor the evolution of antimicrobial resistance and select resistant strains. Brazil is a significant producer and exporter of animal-derived food. Although Brazil is still preparing a national surveillance plan, several changes in legislation and timely programs have been implemented. Thus, Brazilian data on antimicrobial resistance in bacteria associated with animals come from official programs and the scientific community. This review aims to update and discuss the available Brazilian data on this topic, emphasizing legal aspects, incidence, and genetics of the resistance reported by studies published since 2009, focusing on farm animals and derived foods with the most global public health impact. Studies are related to poultry, cattle, and pigs, and mainly concentrate on non-typhoid Salmonella, Escherichia coli, and Staphylococcus aureus. We also describe legal aspects of antimicrobial use in this context; and the current occurrence of genetic elements associated with resistance to beta-lactams, colistin, and fluoroquinolones, among other antimicrobial agents. Data here presented may be useful to provide a better understanding of the Brazilian status on antimicrobial resistance related to farm animals and animal-derived food products.

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Emergence of mcr-1 Producing Salmonella enterica serovar Typhimurium from Retail Meat: First Detection in Brazil

Cited by 30 publications

References 8 publications

Frequency of Antimicrobial Resistance Genes in Salmonella From Brazil by in silico Whole-Genome Sequencing Analysis: An Overview of the Last Four Decades

Frequency of Antimicrobial Resistance Genes in Salmonella From Brazil by in silico Whole-Genome Sequencing Analysis: An Overview of the Last Four Decades

Genetic and Functional Characterization of an MCR-3-Like Enzyme-Producing Escherichia coli Isolate Recovered from Swine in Brazil

Antimicrobial Resistance in Farm Animals in Brazil: An Update Overview

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