Emergence of non-albicans candida species in neonatal candidemia

Abstract

Background:Candida species are one of the most common causes of blood stream infections among neonates and account for 9-13% of such infections. Although Candida albicans remains the most common fungal isolate from neonatal candidemia, longitudinal studies have detected a shift towards non-albicans Candida (NAC) species.Aim:To examine the prevalence and epidemiology of candidemia among infants admitted to our hospital.Materials and Methods:Blood samples were collected from 548 neonates and only those which yielded pure growth of Candida spp. were included in the study. The isolates were identified as per standard mycological techniques and antifungal susceptibility (AFS) was done by disc diffusion method.Results:Of the total 132 neonates included in the study, NAC species were responsible for 80.30% cases with C. parapsilosis (25.0%) and C. tropicalis (21.97%) as the most predominant species; whereas 19.70% of cases were caused by C. albicans. AFS results revealed that 65.91, 73.49, and 96.21% isolates were sensitive to fluconazole (FLK), itraconazole (ITR), and amphotericin B (AMB), respectively.Conclusion:Candidemia in neonates is an ominous prognostic sign and is an important entity in our hospital. Strict infection control strategies, appropriate preventive and therapeutic measures such as prophylactic antifungal use and a restrictive policy of antibiotic use should be implemented.

Neonatal Candida Lusitaniae Septicemia

“…Most cases reported the use of broad-spectrum an bio cs, intravascular catheter, the use of, and the occurrence of granulocytopenia frequently. Both of the neonates received total parentaral nutri on, a known risk factor for the development of fungemia caused by other Candida species 8 . Both of the neonates had C. lusitaniae isolated in blood.…”

Mycoses and Antifungals: reviewing the basis of a current problem that still is a biotechnological target for marine products

“…In the recent years other fungi emerged as important infections agents, including yeast species such as non-albicans Candida species, Cryptococcus sp., Trichosporon spp., and Rhodotorula spp. and filamentous fungi such as Fusarium spp., Rhizopus spp., Rhizomucor spp., and phaeohyphomycosis agents (Sun et al, 2012;Juyal et al, 2013;Kim et al, 2013;Muhammed et al, 2013;Jaın et al, 2014;Schieffelin et al, 2014).…”

Sensitive and rapid RT-qPCR quantification of pathogenic Candida species in human blood

“…The occurrence of NAC bloodstream infections is increasing in several regions (Chang et al, 2008;Li et al, 2013;Pfaller and Diekema, 2007;Pfaller et al, 2010;Rodloff et al, 2011;Takakura et al, 2004). In addition, differences in causative Candida species among age groups have been reported, with higher occurrences of C. glabrata bloodstream infections in the elderly and of C. parapsilosis and C. tropicalis infections in neonates (Juyal et al, 2013;Malani et al, 2005). The variability of emergence and drug susceptibility patterns of these fungi can make it difficult to provide patients with a precise diagnosis and appropriate treatment.…”