Emergence of novel<i>Leptospira</i>serovars: a need for adjusting vaccination policies for dogs?

Arent, Zbigniew; Andrews, SJ; Adαmama-Moraitou, K. K.; Gilmore, C.; Pardali, Dimitra; Ellis, William

doi:10.1017/s0950268812002087

Cited by 38 publications

(31 citation statements)

References 27 publications

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“…This is in accordance with previous reports (Arent and others 2013, Renaud and others 2013). This low cut-off was chosen because the MAT has high specificity in convalescent samples, in which anti-leptospiral IgG predominates (Chernukha and others 1976).…”

Section: Discussionsupporting

confidence: 94%

“…In a study from Germany, 14 per cent of dogs with confirmed leptospirosis had antibody titres to serogroup Pomona (Mayer-Scholl and others 2013). Antibodies to serovar Altodouro were also significantly associated with the presence of clinical disease in a cohort of Greek dogs (Arent and others 2013). It has therefore been suggested that inclusion of serogroup Pomona into future vaccines should be considered (Arent and others 2013).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of antileptospiral serum antibodies in dogs in Ireland

Schüller

Arent²,

Gilmore³

et al. 2015

Veterinary Record

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A total of 474 serum samples from client owned Irish dogs were tested for the presence of antibodies to serovars Canicola, Icterohaemorrhagiae, Bratislava, Autumnalis, Pomona, Altodouro, Grippotyphosa, Mozdok, Hardjobovis and Ballum. Six per cent of dogs presented to veterinary practitioners for problems unrelated to leptospirosis showed evidence of prior exposure to leptospiral serovars belonging to the serogropus Ballum, Australis, Pomona and Sejroe. One unvaccinated dog suspected to have leptospirosis showed seroconversion to serogroup Icterohaemorrhagiae. Based on these results the authors conclude that canine exposure to serogroup Ballum should be monitored because dogs may serve as sentinels for this serovar in the environment. Vaccination with multivalent vaccines containing serovar Bratislava in addition to serogroups Icterohaemorrhagiae and Canicola is advisable.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Prevalence of antileptospiral serum antibodies in dogs in Ireland

Schüller

Arent²,

Gilmore³

et al. 2015

Veterinary Record

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“…Serovar Altodouro, a new serovar from the Leptospira kirschneri genospecies, was recently isolated from a Mus musculus rodent species in the Trás-os-Montes region [1,16]. Later studies in dogs from Greece [17] have shown that this serovar seems highly reactive, which, in addition to our findings, may indicate the need to include serovar Altodouro as antigen in coming leptospirosis serological studies across Europe, concerning both domestic and wild populations. Several other strains from the Pomona group have been previously isolated in Portugal: serovar Mozdok strains from pigs [18] and small mammals [19], and serovar Tsaratsovo from horses [20].…”

supporting

confidence: 64%

Prevalence of Leptospira antibodies in wild boars (Sus scrofa) from Northern Portugal: risk factor analysis

et al. 2014

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Leptospirosis is a zoonosis of worldwide distribution, caused by infection with pathogenic spirochaetes of the genus Leptospira. The wild boar (Sus scrofa), an important hunting species in Europe, seems to play a significant role in the epidemiological cycle of leptospirosis. A total of 101 serum samples from wild boar hunted in Northern Portugal were analysed for leptospiral antibodies detection by microscopic agglutination test. Sera were collected during hunting seasons (2011-2013) and tested with 17 different pathogenic serovars of Leptospira. Antibodies against nine serovars were detected in 66 (65·4%) of these sera. Serovars Tarassovi and Altodouro exhibited the highest seroreactivity rates (23·8% and 16·8%, respectively), followed by Autumnalis (7·9%) and Bratislava (6·9%). Age and district of origin were found to be risk factors for the presence of leptospiral antibodies in contrast to gender. From a One Health perspective, this study revealed that wild boar should be considered as a potential source of leptospirosis dissemination for humans and animal species (domestic and wild) in shared environments, particularly in the Trás-os-Montes region.

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“…Some of them, particularly serovars belonging to L. interrogans species such as serovar Pomona, have been shown to be significant domestic animal pathogens, maintained by pigs (8). However, serogroup Pomona strains clustered in L. kirschneri species, like serovars Mozdok and Altodouro, are maintained by small rodents, although they may also occasionally cause disease in domestic animals (2,13,18). Taking into account all the above data and the fact that bacteriological studies are limited in Poland, definitive comments on the epidemiology of serogroup Pomona infections in animals will require further investigations, as this can only be assessed by renal culture, which was not part of this study.…”

Section: Discussionmentioning

confidence: 99%

First report of Leptospira infections in red deer, roe deer, and fallow deer in Poland

Żmudzki

Jabłoński

Arent

et al. 2016

Journal of Veterinary Research

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Introduction: Recently in Europe an increase in the population of red deer (Cervus elaphus), roe deer (Capreolus capreolus), and fallow deer (Dama dama) has been observed. Research on the prevalence of Leptospira infections in Polish cervids has been performed for the first time. Material and Methods: During 2014/2015 hunting season, 147 blood samples from red deer, roe deer, and fallow deer were collected. The animals originated from different geographical regions across Poland. Serum samples were tested by microscopic agglutination test (MAT) for the presence of specific antibodies to the following Leptospira serovars: Icterohaemorrhagiae, Grippotyphosa, Sejroe, Tarassovi, Pomona, Canicola, Bratislava, Hardjo, Ballum, Zanoni, Hebdomadis, and Poi. Results: Serum antibody titres specific to Grippotyphosa, Pomona, and Zanoni serovars were found; none of the sera were positive for any of the other serovars. Out of 147 serum samples only 7 were positive, which gave an overall prevalence of 4.8% in the tested animal population. Conclusion: The low Leptospira antibody titres along with the low number of positive serum samples in deer indicate that these animals may not act as significant reservoirs of Leptospira for either humans or animals in Poland.

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Emergence of novelLeptospiraserovars: a need for adjusting vaccination policies for dogs?

Cited by 38 publications

References 27 publications

Prevalence of antileptospiral serum antibodies in dogs in Ireland

Prevalence of antileptospiral serum antibodies in dogs in Ireland

Prevalence of Leptospira antibodies in wild boars (Sus scrofa) from Northern Portugal: risk factor analysis

First report of Leptospira infections in red deer, roe deer, and fallow deer in Poland

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