Emergence of OXA-72-producing Acinetobacter pittii clinical isolates

Bonnin, Rémy A.; Docobo-Pérez, Fernando; Poirel, Laurent; Villegas, Maria-Virginia; Nordmann, Patrice

doi:10.1016/j.ijantimicag.2013.10.005

Cited by 10 publications

(8 citation statements)

References 5 publications

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“…In previous studies, bla , bla OXA-40-like and bla OXA-58-like genes have been described for carbapenem-resistant non-A. baumannii isolates from China, Colombia, France, Germany and the Irish Republic (Bonnin et al, 2014;Boo et al, 2006;Evans et al, 2010;Wang et al, 2007). The present study demonstrated for the first time, the coexistence of oxacillinase genes in all carbapenem-resistant A. nosocomialis isolates and the existence of IMP in an A. junii blood isolate, in Iran.…”

Section: Discussionsupporting

confidence: 66%

Characterization of carbapenem-resistant Acinetobacter calcoaceticus–baumannii complex isolates from nosocomial bloodstream infections in southern Iran

Pourabbas

Firouzi

Pouladfar

2016

Journal of Medical Microbiology

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Acinetobacter baumannii is an important opportunistic bacterial pathogen responsible for serious infections in hospitalized patients. From a total of 78 consecutive non-repetitive Acinetobacter spp. isolates from patients with blood infections, 61 were carbapenem resistant, which were positive for bla OXA-51-like (96.7 %), bla OXA-23-like (77 %), bla OXA-58-like (8.1 %) and bla OXA-40-like genes (32.8 %) by multiplex PCR. The isolates were identified as A. baumannii (n559) and Acinetobacter nosocomialis (n52). Also, we found a case of Acinetobacter junii, causing bacteraemia, that possessed the IMP gene. High levels of resistance were observed to fluoroquinolones, aminoglycosides, tigecycline and to the beta-lactam antibiotics, including piperacillin/tazobactam and ampicillin/sulbactam. ISAba1 was present in 96.7 % of all Acinetobacter calcoaceticus-baumannii complex (Acb) isolates. Also, 33 (54.1 %) and 23 (37.7 %) isolates harboured ISAba1 upstream of bla OXA-23-like and bla OXA-51-like genes, respectively, though this was not observed in A. nosocomialis isolates. No relationship was observed between the presence of ISAba1 upstream of oxacillinase genes and the level of carbapenem resistance in all Acb isolates. Only two genes encoding metallo-beta-lactamase (VIM, SPM) were detected in all Acb isolates. This suggests that carbapenem resistance in blood-isolate Acb is mostly due to the presence of acquired carbapenemases. This is the first report from Iran on the identification of A. nosocomialis isolates that possess multiple oxacillinase genes and lack upstream ISAba1.

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Section: Discussionsupporting

confidence: 66%

Characterization of carbapenem-resistant Acinetobacter calcoaceticus–baumannii complex isolates from nosocomial bloodstream infections in southern Iran

Pourabbas

Firouzi

Pouladfar

2016

Journal of Medical Microbiology

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“…OXA-72-producing A. pittii was first described in Colombia in 2012 from a catheter tip–positive culture of a patient who had ischaemic hepatitis and multiorgan failure [6] . This enzyme has subsequently been reported from carbapenem-resistant clinical isolates of A. pittii in France [7] . On the other hand, identification of NDM-positive non- baumannii Acinetobacter is now increasingly reported worldwide, concomitantly with those of A. baumannii isolates.…”

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confidence: 79%

Emergence of NDM-1 and OXA-72 producing Acinetobacter pittii clinical isolates in Lebanon

Atrouni

Joly-Guillou

Hamzé

et al. 2016

New Microbes and New Infections

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“…The increased prevalence of infections and colonization by P . aeruginosa São Paulo metallo-β-lactamases (SPM)-producers suggests that the gene bla SPM-1 settled successfully in plasmids and is associated with high risk of formation of clones, which can facilitate its global spread [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Molecular Epidemiology of Multidrug-Resistant P. aeruginosa Carrying aac(6')-Ib-cr, qnrS1 and blaSPM Genes in Brazil

et al. 2016

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We described a comprehensive analysis of the molecular epidemiology of multidrug-resistant (MDR) P. aeruginosa. Molecular analysis included typing by Pulsed Field Gel Electrophoresis, identification of genes of interest through PCR-based assays and sequencing of target genes. Case-control study was conducted to better understand the prognostic of patients and the impact of inappropriate therapy in patients with bacteremia, as well as the risk factors of MDR infections. We observed a high rate of MDR isolates (40.7%), and 51.0% of them was independently associated with inappropriate antibiotic therapy. Bacteremia was detected in 66.9% of patients, and prolonged hospital stay was expressive in those resistant to fluoroquinolone. Plasmid-mediated quinolone resistance genes (PMQR), qnrS1 and aac(6’)Ib-cr, were detected in two different nosocomial isolates (5.3%), and the aac(6’)-Ib7 variant was detected at a high frequency (87.5%) in those negative to PMQR. The presence of mutations in gyrA and parC genes was observed in 100% and 85% of selected isolates, respectively. Isolates harboring PMQR genes or mutations in gyrA and parC were not closely related, except in those containing SPM (São Paulo metallo-β-lactamase) clone. In addition, there is no study published in Brazil to date reporting the presence of Pseudomonas aeruginosa isolates harboring both qnrS1 and aac(6’)Ib-cr genes, with alarming frequency of patients with inappropriate therapy.

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Emergence of OXA-72-producing Acinetobacter pittii clinical isolates

Cited by 10 publications

References 5 publications

Characterization of carbapenem-resistant Acinetobacter calcoaceticus–baumannii complex isolates from nosocomial bloodstream infections in southern Iran

Characterization of carbapenem-resistant Acinetobacter calcoaceticus–baumannii complex isolates from nosocomial bloodstream infections in southern Iran

Emergence of NDM-1 and OXA-72 producing Acinetobacter pittii clinical isolates in Lebanon

Clinical and Molecular Epidemiology of Multidrug-Resistant P. aeruginosa Carrying aac(6')-Ib-cr, qnrS1 and blaSPM Genes in Brazil

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