Emergence of resistance to antibacterial agents: the role of quaternary ammonium compounds—a critical review

Buffet-Bataillon, Sylvie; Tattevin, Pierre; Bonnaure‐Mallet, Martine; Jolivet‐Gougeon, Anne

doi:10.1016/j.ijantimicag.2012.01.011

Cited by 502 publications

(352 citation statements)

References 139 publications

(157 reference statements)

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“…MDR1, FLU1, BENr; molecular alterations of the lanosterol 14-α demethylase, the target enzyme of the azoles being the basic two mechanisms. A wide range of antifungal agents as antibiotics, drugs, quaternary ammonium compounds have been used to treat such infections, however these are associated with major disadvantages of antibiotic resistance, limited activity, environmental toxicity and complex synthesis procedure [7].…”

Section: Discussionmentioning

confidence: 99%

Nano Based Therapy for Biofilm Management: Mini Review

Rawat¹

2017

JNMR

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High toxicity, low host tolerance, narrow spectrum of antifungal drugs and increasing incidence of azole-resistance complicates treatment of invasive Candida infections. Due to the emergence of antimicrobial resistance as an increasing threat to global health care, arises the need to develop new, and effective broad spectrum active antifungal agents. Thus understanding and combating drug resistance in Candida albicans is a toughest challenge being faced today and it's immensely important to develop an alternative coating that can inhibit biofilm formation on medical devices as implants and catheters. Additionally, the fascinating properties of nanomaterials and biocompatibility promises great potential in nanomedical applications, especially in medical microbiology. With appropriate modification of these synthetic materials, several disease infections can be cured and results have shown the use of these nanomaterials as diagnostic and immunotherapauetic agents. Since, antimicrobial resistance is becoming a major apprehension worldwide, nanomedicines offer an intriguing and promising solution for combating these high resistance pathogens by appropriate development of therauptic and novel diagnosis approaches. This mini review presents the current state of art in this emerging field.

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Section: Discussionmentioning

confidence: 99%

Nano Based Therapy for Biofilm Management: Mini Review

Rawat¹

2017

JNMR

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“…However, they are also commonly used against Gram-positive and Gram-negative bacteria. The antimicrobial activity of these substances depends mainly on the length of the N-alkyl chain [28]. Disinfectants based on QAC are used widely in the pharmaceutical, cosmetic, and food industries [29].…”

Section: Minimal Inhibitory Concentrationmentioning

confidence: 99%

“…The hydrophobic tail of the quaternary ammonium compound integrates into the microbial hydrophobic membrane core. The activity of QAC may also involve the disruption and denaturation of proteins and enzymes, as well as induction of dose-and time-dependent ultrastructural changes [28].…”

Section: Minimal Inhibitory Concentrationmentioning

confidence: 99%

“…compound integrates into the microbial hydrophobic membrane core. The activity of QAC may also involve the disruption and denaturation of proteins and enzymes, as well as induction of dose-and time-dependent ultrastructural changes [28]. At low concentrations, the activity of QAC results in the loss of osmoregulatory capability and leakage of potassium ions and protons.…”

Section: Minimal Inhibitory Concentrationmentioning

confidence: 99%

“…What is more, in some cases, results were higher for samples pretreated by QE. The action of QE and QAC is generally based on the interactions with cell membranes, disruption of membrane integrity, and leakage of intracellular content, including ATP [28,30]. Due to the fact that the bioluminescence measurement is based on the ATP determination, the higher results of RLU/cm 2 may be caused by higher levels of ATP releasing from cells after treatment by QAC at higher concentrations.…”

Section: Biofilm Eradicationmentioning

confidence: 99%

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Quillaja saponaria Saponins with Potential to Enhance the Effectiveness of Disinfection Processes in the Beverage Industry

et al. 2018

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Featured Application: The extract of Q. saponaria can be used as a pretreatment agent to increase the sensibility of microorganisms to disinfectants. The results can be used to develop a strategy for the control of biofilms in beverage industry.Abstract: This study examines the in vitro effect of Quillaja saponaria extracts on Asaia spp. planktonic cells and biofilms, in comparison and combination with two disinfectants: peracetic acid and N-ethyl-N,N-dimethylhexadecylammonium bromide. The growth of six bacterial strains was evaluated spectrophotometrically. Biofilm eradication was determined using the plate count method and luminometry. The planktonic cells were characterized by relatively high resistance to peracetic acid and higher sensitivity to N-ethylo-N,N-dimethylohexadecylioamonium bromide. In almost all the tested strains, growth was inhibited by 0.125% (v/v) peracetic acid and 0.0313% (w/v) quaternary ammonium compound. However, combinations of cell pretreatment using saponin and peracetic acid action were the most efficient against both planktonic and biofilm cells. The minimum inhibitory concentrations for peracetic acid were 4-8 times lower than those for bacterial strains without preliminary saponin action. Eradication of Asaia spp. biofilms reduced the number of living cells by 4-5 logarithmic units. These results demonstrate the synergetic action of saponin extract and disinfectant, and could be useful in the development of industrial strategies against Asaia spp. biofilms.

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Prevention and Control of Biofilms in the Food Industry and Bio‐Nanotechnology Approaches

Birkenhauer

Neethirajan

2015

Biofilms in the Food Environment

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Emergence of resistance to antibacterial agents: the role of quaternary ammonium compounds—a critical review

Cited by 502 publications

References 139 publications

Nano Based Therapy for Biofilm Management: Mini Review

Nano Based Therapy for Biofilm Management: Mini Review

Quillaja saponaria Saponins with Potential to Enhance the Effectiveness of Disinfection Processes in the Beverage Industry

Prevention and Control of Biofilms in the Food Industry and Bio‐Nanotechnology Approaches

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