Emergence of Streptococcus suis serotype 9 infection in humans

Kerdsin, Anusak; Hatrongjit, Rujirat; Gottschalk, Marcelo; Takeuchi, Dan; Hamada, Shigeyuki; Akeda, Yukihiro; Oishi, Kazunori

doi:10.1016/j.jmii.2015.06.011

Cited by 69 publications

(62 citation statements)

References 4 publications

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“…Seventeen of these strains originated from Canada, 3 from Brazil, 1 from Denmark (reference strain), and 4 from Germany. A strain isolated from a human case of infection was also included [7]. The S .…”

Section: Methodsmentioning

confidence: 99%

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Serotype-specific role of antigen I/II in the initial steps of the pathogenesis of the infection caused by Streptococcus suis

Chuzeville

Auger

Dumesnil

et al. 2017

Vet Res

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Streptococcus suis is one of the most important post-weaning porcine bacterial pathogens worldwide. The serotypes 2 and 9 are often considered the most virulent and prevalent serotypes involved in swine infections, especially in Europe. However, knowledge of the bacterial factors involved in the first steps of the pathogenesis of the infection remains scarce. In several pathogenic streptococci, expression of multimodal adhesion proteins known as antigen I/II (AgI/II) have been linked with persistence in the upper respiratory tract and the oral cavity, as well as with bacterial dissemination. Herein, we report expression of these immunostimulatory factors by S. suis serotype 2 and 9 strains and that AgI/II-encoding genes are carried by integrative and conjugative elements. Using mutagenesis and different in vitro assays, we demonstrate that the contribution of AgI/II to the virulence of the serotype 2 strain used herein appears to be modest. In contrast, data demonstrate that the serotype 9 AgI/II participates in self-aggregation, induces salivary glycoprotein 340-related aggregation, contributes to biofilm formation and increased strain resistance to low pH, as well as in bacterial adhesion to extracellular matrix proteins and epithelial cells. Moreover, the use of a porcine infection model revealed that AgI/II contributes to colonization of the upper respiratory tract of pigs. Taken together, these findings suggest that surface exposed AgI/II likely play a key role in the first steps of the pathogenesis of the S. suis serotype 9 infection.Electronic supplementary materialThe online version of this article (doi:10.1186/s13567-017-0443-4) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

“…Yet, very few studies have addressed the presence of virulence factors in this serotype, and putative virulence factors described for serotype 2 strains may not always be present in serotype 9 strains [6]. Moreover, the first S. suis serotype 9 human case of infection was reported in 2015 [7]. …”

Section: Introductionmentioning

confidence: 99%

Serotype-specific role of antigen I/II in the initial steps of the pathogenesis of the infection caused by Streptococcus suis

Chuzeville

Auger

Dumesnil

et al. 2017

Vet Res

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“…In 2005, the largest outbreak of human infection, caused by S. suis serotype 2 (SS2) so far reported, occurred in Sichuan Province of China (more than 150 cases and 30 reported deaths), while a smaller outbreak had previously occurred in 1998 (Kerdsin et al, 2011;Palmieri et al, 2011). These severe outbreaks posed serious concerns to public health.…”

Section: Streptococcus Suismentioning

confidence: 99%

Microbiological Zoonotic Emerging Risks, Transmitted Between Livestock Animals and Humans (2007-2015)

Filippitzi

Goumperis

Robinson

et al. 2016

Transbound Emerg Dis

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Summary As part of the Emerging Risk Identification (ERI) activities of the European Food Safety Authority (EFSA), a literature search was conducted to identify the microbiological agents transmitted between livestock animals and humans that have been suggested as having emerged between 2007 and 2015 in peer‐reviewed scientific literature published during the same period (2007–2015). According to the criteria set, the search identified seven such zoonotic agents, namely West Nile Fever virus, Rift Valley Fever virus, Crimean‐Congo Haemorrhagic Fever virus, Influenza A H1N1 virus, Coxiella burnetii, Streptococcus suis and livestock‐associated methicillin‐resistant Staphylococcus aureus clonal complex 398. An explanation of the agents' consideration as emerging risks is provided. The experience gained from these emergences has shown that the detection of and response to such risks can be achieved faster and more successfully within a multidisciplinary, collaborative context at the field, local, national and international levels.

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“…To develop a multiplex PCR assay covering the major CCs of Streptococcus suis relevant to human infections, including CC1, CC25, CC28, CC104, CC221/234 and CC233/ 379 (Feil et al, 2008, Kerdsin et al, 2011a; http://ssuis. mlst.net/), we selected hp1, mp, pep and col of the CC104-specific sequences as targets for primer design, including the srtBCD primers described by Takamatsu et al (2009).…”

Section: Multiplex Pcr For Streptococcus Suis Ccsmentioning

confidence: 99%

“…A second study described a PCR assay to determine how pilus-associated gene profiles correlated with CCs of Streptococcus suis (Takamatsu et al, 2009 (Kerdsin et al, 2015), our multiplex PCR assay could not be used to amplify this isolate (Table 1, Fig. 1).…”

Section: Multiplex Pcr For Streptococcus Suis Ccsmentioning

confidence: 99%

Development of a multiplex PCR assay to detect the major clonal complexes of Streptococcus suis relevant to human infection

Hatrongjit

Kerdsin

Gottschalk

et al. 2016

Journal of Medical Microbiology

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Multilocus sequence typing (MLST) is considered a reliable method for providing insight into the Streptococcus suis population structure, clonal relationships and the potential of particular clones to cause disease. Indeed, MLST has revealed the presence of several clonal complexes (CCs) within the Streptococcus suis population. However, the method is costly, time-consuming and difficult to use for screening large numbers of isolates. In this study, a multiplex PCR assay was developed to identify Streptococcus suis CCs that are relevant to human infections. The multiplex PCR assay was capable of simultaneously distinguishing CC1, CC25, CC28, CC104, CC221/234 and CC233/379, which are related to human infections in Thailand, in a single reaction. The multiplex PCR assay is useful for low-cost screening of large numbers of isolates with rapid analytical capacity and could be utilized in most laboratories.

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Emergence of Streptococcus suis serotype 9 infection in humans

Cited by 69 publications

References 4 publications

Serotype-specific role of antigen I/II in the initial steps of the pathogenesis of the infection caused by Streptococcus suis

Serotype-specific role of antigen I/II in the initial steps of the pathogenesis of the infection caused by Streptococcus suis

Microbiological Zoonotic Emerging Risks, Transmitted Between Livestock Animals and Humans (2007-2015)

Development of a multiplex PCR assay to detect the major clonal complexes of Streptococcus suis relevant to human infection

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