Hydrogen, which has a high energy density and does not emit pollutants, is considered an alternative energy source to replace fossil fuels. Herein, we report an experimental study on hydrogen leaks and ventilation methods for preventing damage caused by leaks from hydrogen fuel cell rooms in homes, among various uses of hydrogen. This experiment was conducted in a temporary space with a volume of 11.484 m3. The supplied pressure, leak-hole size, and leakage amount were adjusted as the experimental conditions. The resulting hydrogen concentrations, which changed according to the operation of the ventilation openings, ventilation fan, and supplied shutoff valve, were measured. The experimental results showed that the reductions in the hydrogen concentration due to the shutoff valve were the most significant. The maximum hydrogen concentration could be reduced by 80% or more if it is 100 times that of the leakage volume or higher. The shutoff valve, ventilation fan, and ventilation openings were required to reduce the concentrations of the fuel cell room hydrogen in a spatially uniform manner. Although the hydrogen concentration in a small hydrogen fuel cell room for home use can rapidly increase, a rapid reduction in the concentration of hydrogen with an appropriate ventilation system has been experimentally proven.