Emergency splenectomy for trauma in the setting of splenomegaly, axillary lymphadenopathy, and incidental B-cell chronic lymphocytic leukemia: A case report

Oviedo, Rodolfo J.; Glickman, Andrew A.

doi:10.1016/j.ijscr.2017.06.032

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…The most affected group in CLL is the geriatric population 7 . Diagnosis of CLL is usually incidental as it lies dormant for long periods of time.…”

Section: Discussionmentioning

confidence: 99%

Diagnosing a hematopoietic malignancy during shoulder arthroplasty: A case report

et al. 2022

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Introduction. Determining the cause of shoulder pain requires is usually a challenge as many problems; such as rheumatoid arthritis, osteoarthritis, osteonecrosis, rotator cuff arthropathy, traumatic arthritis, fractures, conditions of cervical vertebra and neoplasms, can produce similar symptoms. The diagnosis is usually regarded incidental however, CLL diagnosis by histopathological evaluation performed on lymph nodes excised during a shoulder procedure has not been reported in literature, to the best of our knowledge. We share our experience on a CLL - small lymphocytic lymphoma (SLL) case diagnosed incidentally during reverse shoulder arthroplasty in this report. Case report. We report a case of a 69-year-old woman diagnosed with chronic lymphocytic leukemia - small lymphoblastic lymphoma, subsequent to excision of an cephalic lymph node which was incidentally determined during shoulder arthroplasty. Conclusion. Upon admission, patient had no history of malignancy, no pathologic findings on physical examination and only had proximal humerus nonunion determined on radiographs.

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“…The most affected group in CLL is the geriatric population 7 . Diagnosis of CLL is usually incidental as it lies dormant for long periods of time.…”

Section: Discussionmentioning

confidence: 99%

Diagnosing a hematopoietic malignancy during shoulder arthroplasty: A case report

et al. 2022

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“…While the clinical significance of this undiagnosed process is uncertain, this case highlights that the spleen may harbour the first and sometimes only manifestation of an indolent haematopoietic process. To our knowledge, few reports of splenic lymphoma incidentally discovered upon histological diagnosis have been reported, including splenic marginal zone lymphomas and CLL/SLL …”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, few reports of splenic lymphoma incidentally discovered upon histological diagnosis have been reported, including splenic marginal zone lymphomas 13 and CLL/SLL. 14 Both cases with CLL/SLL immunophenotype occurred in the setting of a concurrent pancreatic neuroendocrine tumour. While CLL has been associated with increased incidence of solid tumours, 15 simultaneous CLL and pancreatic neuroendocrine tumour is relatively rare.…”

Section: Discussionmentioning

confidence: 99%

Incidental splenic findings in pancreatosplenectomy specimens resected for primary pancreatic lesions

et al. 2019

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Aims Little has been written on the frequency and nature of incidental splenic lesions diagnosed on histopathological examination of pancreatosplenectomy specimens. Methods and results For 191 such specimens, incidental histological findings after haematopathologist re‐review were tabulated. Cases suspicious for lymphoid malignancy underwent molecular analysis for immunoglobulin heavy and kappa light chain rearrangement. Follow‐up was obtained on selected cases. In five cases (3%), the spleen was sampled but not mentioned in the original microscopic report; all were normal on re‐review. Otherwise, most (171 of 186, 92%) were initially diagnosed as normal, with 160 (94%) remaining so on re‐review. Findings on re‐review not initially described (n = 11, 6%) included four cases with splenic morphology suspicious for possible leukaemia/lymphoma involvement. Additional findings included abscess formation, foamy macrophages, necrotising granulomas and simple cysts. Fifteen spleens were initially diagnosed as abnormal; the histopathological process was confirmed in all, including non‐necrotising granulomas, cysts, Gamna–Gandy bodies, foamy macrophages, involvement by pancreatic neoplasm and involvement by known chronic lymphocytic leukaemia (CLL). Molecular analysis was performed on the five cases of known/suspected lymphoma and two were positive for monoclonal gene rearrangement, including the known CLL and a previously undiagnosed case with similar immunophenotype. Conclusions Incidental splenic findings are not uncommon in pancreatosplenectomy specimens. While most are of limited clinical significance, low‐grade lymphoproliferative disorders may go undetected if the spleen is overlooked. We recommend careful observation of splenic findings in these specimens, with a low threshold for haematopathological consultation when in doubt.

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Bendamustine/rituximab

2017

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Emergency splenectomy for trauma in the setting of splenomegaly, axillary lymphadenopathy, and incidental B-cell chronic lymphocytic leukemia: A case report

Cited by 4 publications

References 14 publications

Diagnosing a hematopoietic malignancy during shoulder arthroplasty: A case report

Diagnosing a hematopoietic malignancy during shoulder arthroplasty: A case report

Incidental splenic findings in pancreatosplenectomy specimens resected for primary pancreatic lesions

Bendamustine/rituximab

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