Emerging Antibiotic Resistance to Bacterial Isolates from Human Urinary Tract Infections in Grenada

Sharma, Deepak; Preston, Sara; Hage, Robert

doi:10.7759/cureus.5752

Cited by 13 publications

(15 citation statements)

References 14 publications

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“…In our analysis, in both periods, the most common organisms were Escherichia coli (56.6% vs 51.6%), Klebsiella pneumoniae (14.7% vs 16.5%), Enterococcus faecalis (11.6% vs 12%), and Pseudomonas aeruginosa (4.5% vs 5%). This spectrum is similar to the previous studies by Meena et al [ 12 ], and Shah et al [ 6 ] from India; Sorlozano et al [ 13 ] from Spain; Eure et al [ 14 ] and Sharma et al [ 15 ] from Grenada; and Lagunas-Rangel [ 16 ] from Mexico. Most authors have reported Escherichia coli and Klebsiella pneumoniae among the top three causative organisms for UTI (Table 4 ), which is similar to our study.…”

Section: Discussionsupporting

confidence: 90%

Antimicrobial Resistance Among Uropathogens: Surveillance Report From South India

Ravishankar¹,

P²,

Premamalini³

2021

Cureus

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Section: Discussionsupporting

confidence: 90%

Antimicrobial Resistance Among Uropathogens: Surveillance Report From South India

Ravishankar¹,

P²,

Premamalini³

2021

Cureus

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“…In Grenada, Sharma et al . [ 35 ] showed that 65.4% of the isolates were Gram-negative bacteria with E . coli being the frequently isolated species (51.5%), followed by K .…”

Section: Resultsmentioning

confidence: 99%

“…(1.0%). In Grenada, Sharma et al [35] showed that 65.4% of the isolates were Gram-negative bacteria with E. coli being the frequently isolated species (51.5%), followed by K. pneumoniae (20.0%) and P. mirabilis (10.0%). The high predominance of E. coli in patients with UTI is expected and it is well known by physicians and researchers all over the world as this bacterium represents a normal component of the intestinal microbiota of humans and animals and has strains with the potential of causing UTI and other extraintestinal infections.…”

Section: Prevalence Of E Coli Among Uropathogensmentioning

confidence: 99%

Prevalence of common carbapenemase genes and multidrug resistance among uropathogenic Escherichia coli phylogroup B2 isolates from outpatients in Wasit Province/ Iraq

et al. 2022

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Carbapenems are the last resort antimicrobials for the treatment of extended spectrum β-lactamases (ESBLs) producing Enterobacteriaceae. Emergence of carbapenems resistant group B2 uropathogenic E. coli (UPEC) is a major concern because of their high virulence. Prevalence of these enzymes and multidrug resistance (MDR) among B2 UPEC isolates from Iraqi outpatients with acute urinary tract infection (UTI) was evaluated in this research. Urine cultures were performed and the isolates were identified biochemically. Escherichia coli isolates were tested for phylogroup reference by quadraplex PCR, then B2 isolates were detected for antimicrobial resistance by disc diffusion test and carbapenemase genes by PCR. Escherichia coli was the most prevalent among Gram-negative isolates (66.6%) and B2 was the most detected phylogroup among E. coli isolates (33.9%). Most of B2 isolates showed high resistance rates to tested antimicrobials, especially β-lactams with MDR revealed in 100% of them. Whereas, low resistance rates were noted against carbapenems, aminoglycosides and nitrofurantoin. Carbapenemase genes were detected in 76.3% of B2 isolates. Of which, blaOXA-48 was the most frequent (57.8%), followed by blaPER (47.3%), blaKPC (15.7%), blaVEB and blaVIM (10.5%, for each). Whereas, blaGES and blaIMP genes were not found. Coproduction of these genes occurred among 17 isolates. The combination of blaOXA-48 and blaPER was the most frequent (41.1%). All carbapenemase producing isolates were MDR. These results revealed high prevalence of carbapenemase genes and MDR among B2 UPEC recovered in this study. In the study area. it is strongly advised to use aminoglycosides and nitrofurantoin for empirical treatment of UPEC.

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“…Comparable results were reported in Ethiopia, where 78% of Gram-negative strains were resistant to ampicillin [ 27 ]. Lower ampicillin resistance rates were observed in India ( R > 35%) [ 28 ]. Our data demonstrated that carbapenems could be used for the treatment of infections caused by Gram-negative strains.…”

Section: Discussionmentioning

confidence: 99%

Trend of Bacterial Uropathogens and Their Susceptibility Pattern: Study of Single Academic High-Volume Center in Italy (2015–2019)

Serretiello

Folliero

Santella

et al. 2021

International Journal of Microbiology

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Urinary tract infections (UTIs) are a very widespread infection that can occur in disparate age range, in both sexes and in pregnancy/menopause state. Treatment of UTIs is difficult due to the emergence of antibiotic-resistant bacterial strains. The present study shows five years of data collected on patients admitted at the University Hospital “San Giovann di Dio e Ruggi d’Aragona” in Salerno, Italy. The investigation exhibits the incidence of the infection, of the gender, and of the age group affected, identifying the most representative bacteria involved, drawing their profile of antimicrobial resistance. Bacterial identification and antibiotic susceptibility testing were performed using the VITEK 2 system. Among the 46382 studied patients, 9896 (21.34%) and 36486 (78.66%) were positive and negative for microorganism growth, respectively. Of 9896 positive patients, 6158 (62.23%) females and 3738 (37.77%) males were identified. The highest incidence of positive subjects (56.66%) was recorded in the elderly (>61 years). 8431 (85.20%) uropathogens were Gram-negative, 1367 (13.81%) were Gram-positive, and 98 (0.99%) were Candida species (Candida spp.). Escherichia coli (E. coli) and Enterococcus faecalis (E. faecalis) were the most representative Gram-negative and Gram-positive strains, respectively. The Gram-negative bacteria most representative were highly resistant to ampicillin, whereas among the Gram-positive bacteria, E. faecalis was highly resistant to gentamicin and streptomycin high level synergy, and Enterococcus faecium (E. faecium) to ampicillin, ampicillin/sulbactam, and imipenem. This retrospective work investigates the local epidemiological trend in our university hospital in order to induce an increasingly targeted empirical therapeutic approach for the treatment of UTIs.

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Emerging Antibiotic Resistance to Bacterial Isolates from Human Urinary Tract Infections in Grenada

Cited by 13 publications

References 14 publications

Antimicrobial Resistance Among Uropathogens: Surveillance Report From South India

Antimicrobial Resistance Among Uropathogens: Surveillance Report From South India

Prevalence of common carbapenemase genes and multidrug resistance among uropathogenic Escherichia coli phylogroup B2 isolates from outpatients in Wasit Province/ Iraq

Trend of Bacterial Uropathogens and Their Susceptibility Pattern: Study of Single Academic High-Volume Center in Italy (2015–2019)

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