Emerging application of magnetic nanoparticles for breast cancer therapy

Dongsar, Tenzin Tsering; Dongsar, Tenzin Sonam; Abourehab, Mohammed A.S.; Gupta, Neelima; Kesharwani, Prashant

doi:10.1016/j.eurpolymj.2023.111898

Cited by 54 publications

(7 citation statements)

References 121 publications

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“…If detected early, it can be treated via chemotherapy, radiotherapy, etc., but if left treated, it can spread to other organs like the brain, bones, etc. [ 5 , 9 , 25 , 85 – 90 ].…”

Section: Gold Nanoparticles For Combating Cancermentioning

confidence: 99%

Gold nanoparticles and gold nanorods in the landscape of cancer therapy

et al. 2023

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Cancer is a grievous disease whose treatment requires a more efficient, non-invasive therapy, associated with minimal side effects. Gold nanoparticles possessing greatly impressive optical properties have been a forerunner in bioengineered cancer therapy. This theranostic system has gained immense popularity and finds its application in the field of molecular detection, biological imaging, cancer cell targeting, etc. The photothermal property of nanoparticles, especially of gold nanorods, causes absorption of the light incident by the light source, and transforms it into heat, resulting in tumor cell destruction. This review describes the different optical features of gold nanoparticles and summarizes the advance research done for the application of gold nanoparticles and precisely gold nanorods for combating various cancers including breast, lung, colon, oral, prostate, and pancreatic cancer.

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“…If detected early, it can be treated via chemotherapy, radiotherapy, etc., but if left treated, it can spread to other organs like the brain, bones, etc. [ 5 , 9 , 25 , 85 – 90 ].…”

Section: Gold Nanoparticles For Combating Cancermentioning

confidence: 99%

Gold nanoparticles and gold nanorods in the landscape of cancer therapy

et al. 2023

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“…From the standpoint of research and development, nanoparticulate agents used in cancer imaging can be split into two groups: those that target blood vessels and those that selectively target cancerous cells. In regards, a variety of nanoparticle-based targeted agents have been created for use with various detection methods [ 19 – 24 , 29 , 30 , 37 , 43 – 45 ] (Table 1 ).…”

Section: Nanoparticle-based Cancer Imagingmentioning

confidence: 99%

New opportunities for RGD-engineered metal nanoparticles in cancer

et al. 2023

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The advent of nanotechnology has opened new possibilities for bioimaging. Metal nanoparticles (such as gold, silver, iron, copper, etc.) hold tremendous potential and offer enormous opportunities for imaging and diagnostics due to their broad optical characteristics, ease of manufacturing technique, and simple surface modification. The arginine-glycine-aspartate (RGD) peptide is a three-amino acid sequence that seems to have a considerably greater ability to adhere to integrin adhesion molecules that exclusively express on tumour cells. RGD peptides act as the efficient tailoring ligand with a variety of benefits including non-toxicity, greater precision, rapid clearance, etc. This review focuses on the possibility of non-invasive cancer imaging using metal nanoparticles with RGD assistance. Graphical abstract

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“…In 2018, cancer was the second leading cause of death worldwide, with breast cancer being the deadliest form among women, irrespective of their country's development status (1) . Originating from mammary cells, untreated breast cancer can metastasize, making early detection crucial for effective treatment options like radiotherapy or chemotherapy (2) .…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus kefiri Suppresses Inflammatory Cytokine Expression and Induces Apoptosis in Breast Cancerous Cells in Rat Model

2024

The Egyptian Journal of Hospital Medicine

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Background: Lactobacillus kefiri (L. kefiri), found in kefir, is noted for its health benefits, including potential breast cancer prevention.Objectives: This study aimed to assess the apoptotic and therapeutic effects of L. kefiri on breast carcinoma in rats. Methods: Five groups of 10 rats each were used: Group 1 (negative control) had no tumors, group 2 where rats in this group were injected subcutaneously with a single dose of 50 mg/kg b.w. of DMBA (in 2 ml of corn oil) into the mammary gland, allowed to develop tumors over a period of 120 days. In the third group (L. kefiri oral "Group 3"), tumor-bearing rats received 0.4 ml of L. kefiri orally, six times a week for 5 weeks. Lactobacillus injection (Group 4) where tumor-bearing rats received 0.1 ml of L. kefiri solution via intraperitoneal injection twice a week for 5 weeks. Finally, the L. kefiri mix group (Group 5) where tumor-bearing rats received L. kefiri solution through duo ways: orally with 0.4 ml six times per week and intraperitoneally with 0.1 ml per tumor twice a week for five weeks. Results: DMBA reduced TNFR1, cytochrome c, TRADD, and Bax levels, while increasing Bcl-2 level. L. kefiri reversed these effects, promoting apoptosis in cancer cells. It also improved liver and kidney function markers, reduced oxidative stress and enhanced immunity as shown by better antioxidant levels and lower malondialdehyde. Conclusion: L. kefiri showed promise as a natural agent against breast cancer, warranting further research to determine its mechanisms and optimal application for human health.

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Emerging application of magnetic nanoparticles for breast cancer therapy

Cited by 54 publications

References 121 publications

Gold nanoparticles and gold nanorods in the landscape of cancer therapy

Gold nanoparticles and gold nanorods in the landscape of cancer therapy

New opportunities for RGD-engineered metal nanoparticles in cancer

Lactobacillus kefiri Suppresses Inflammatory Cytokine Expression and Induces Apoptosis in Breast Cancerous Cells in Rat Model

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