Emerging biopharmaceuticals from marine actinobacteria

Hassan, Syed Shams ul; Anjum, Komal; Abbas, Syed Qamar; Akhter, Najeeb; Shagufta, Bibi Ibtesam; Shah, Sayed Asmat Ali; Tasneem, Umber

doi:10.1016/j.etap.2016.11.015

Cited by 55 publications

(22 citation statements)

References 80 publications

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“…The rate of finding new bioactive metabolites from the species of soil habitats has reduced. Therefore, a few attempts have been made to understand the microbial diversity of marine sediments which are an inexhaustible resource for the search of new drugs (Hassan et al, 2017). …”

Section: Introductionmentioning

confidence: 99%

Biological Significance of Marine Actinobacteria of East Coast of Andhra Pradesh, India

Kavitha

Savithri

2017

Front. Microbiol.

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An attempt was made to identify actinobacterial strains present in the marine soil of East Coast regions viz., Chirala, Bapatla, and Peddaganjam, Andhra Pradesh; Kanyakumari, Tamil Nadu and Goa, Goa along with the study of their antimicrobial potential. Eight out of 73 actinobacterial strains isolated from these regions showed strong antimicrobial activity against Gram positive bacteria, Gram negative bacteria, and Candida albicans. Molecular identification (16S rRNA analysis) of the eight strains revealed that they belong to Dietzia sp., Kocuria sp., Nocardiopsis sp., and Streptomyces spp. ISP (International Streptomyces project) -1, ISP-2 and starch casein media supported high antimicrobial potential after 5–6 days of growth. Production of antimicrobials by the strains varied significantly with different carbon and nitrogen sources. Gas chromatography mass spectrometry (GCMS) analysis of volatile compounds produced by the strains illustrated an array of antimicrobial compounds such as 1, 2-benzene dicarboxylic acid, 2-piperidinone, pyrrolo[1,2-a]pyrazine-1,4-dion, phenyl ethyl alcohol, 3-phenyl propionic acid etc. Ours is the first report on the study and detection of above mentioned antimicrobial metabolites from Dietzia sp. (A3), Kocuria sp. (A5), and Nocardiopsis sp. (A7). By sequence based analysis for secondary metabolites, non-ribosomal peptide synthetase (NRPS) gene cluster was noticed in six strains (A2, A3, A4, A6, A7, and A8) and none of them had polyketide synthase (PKS) system. The present study intimates the biological potentiality of the actinobacterial strains isolated from East Coast of Andhra Pradesh, India which reveals further scope to investigate new bioactive compounds from them by employing both natural product chemistry and modern biotechnological aspects.

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Section: Introductionmentioning

confidence: 99%

Biological Significance of Marine Actinobacteria of East Coast of Andhra Pradesh, India

Kavitha

Savithri

2017

Front. Microbiol.

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“…Actinomycetes are one of the most indispensable and vibrant bioactive compounds producing microorganisms found in both terrestrial and marine environments. These actinomycetes are fertile producers of antibiotics and new chemical entities as intracellular/ extra cellular secondary metabolites (Hassan et al 2017). Soil samples have been screened for decades and only very few taxa of actinomycetes have been isolated and studied (Abd-Elnaby et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Antagonistic activity of terrestrial <i>Streptomyces</i> sp. VITNK9 against Gram negative bacterial pathogens affecting the fish and shellfish in aquaculture

Nabila

Каннабиран

2018

RBMO

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Resumen.-Se realizaron un total de 72 aislamientos de actinomicetos morfológicamente diferentes a partir de muestras recolectadas en diferentes regiones de Vellore, Tamil Nadu, India y seleccionados por su actividad antibacteriana contra patógenos de peces y mariscos. Todos los aislamientos de actinomicetos fueron examinados para determinar la actividad antibacteriana por el método de rayas cruzadas contra los patógenos seleccionados de peces y mariscos incluyendo Aeromonas caviae, Aeromonas hydroplila, Edwardsiella tarda, Vibrio anguillarum, Vibrio harveyi. El tamizaje secundario de aislamientos antagonistas por el método de difusión de pozos conduce a la identificación de aislamiento potencial. Las condiciones de cultivo para el aislamiento potencial fue optimizado para un crecimiento y rendimiento máximo del extracto bruto de acetato de etilo (EA). El aislamiento potencial se caracterizó por la taxonomía molecular y filogenia identificándose la especie como Streptomyces y nombrado Streptomyces sp. VITNK9. La secuencia de nucleótidos 16S rDNA fue buscada a través de la base de datos GenBank y mostró 83% de similitud con Streptomyces vinaceusdrappus. El extracto EA preparado a partir de Streptomyces sp. VITNK9 mostró actividad antagonista moderada a la que se accede por la zona de formación de inhibición del crecimiento, Aeromonas caviae (15,33 mm), Aeromonas hydrophila (17,66 mm), Edwardsiella tarda (18,33 mm), Vibrio anguillarum (14,33 mm) y Vibrio harveyi (14,33 mm). El valor de CIM del extracto de EA estaba comprendido entre 0,03 y 0,125 mg mL-1. El espectro de GC-MS del extracto de acetato de etilo reveló la presencia de dos compuestos principales, pirrolo [1,2-a] pirazina-1,4-diona (56,67%) y hexahidro-3-(2-metilpropil) (27,91%), respectivamente. Los resultados del estudio sugieren que Streptomyces sp. VITNK9 es una fuente potencial de metabolitos secundarios antagónicos contra patógenos de peces y mariscos.

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“…For years, researchers have roamed the seas and oceans in search of organisms possessing chemicals that could exhibit therapeutic effects. These include a wide variety of creatures, such as tunicates, mollusks, sponges, bacteria, seaweeds, chordates, mangroves, sea hares, and sharks [ 1 , 2 , 3 ]. Therapeutic indications include cancer, Alzheimer’s disease, thrombosis, hypertension, psoriasis, asthma, and pain [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

et al. 2018

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The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles and to link drug concentrations to clinical outcomes. This review outlines the different analytical methods that have been described for marine-derived drugs in cancer treatment hitherto. It focuses on the major parts of the bioanalytical technology, including sample type, sample pre-treatment, separation, detection, and quantification.

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Emerging biopharmaceuticals from marine actinobacteria

Cited by 55 publications

References 80 publications

Biological Significance of Marine Actinobacteria of East Coast of Andhra Pradesh, India

Biological Significance of Marine Actinobacteria of East Coast of Andhra Pradesh, India

Antagonistic activity of terrestrial <i>Streptomyces</i> sp. VITNK9 against Gram negative bacterial pathogens affecting the fish and shellfish in aquaculture

Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

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