Emerging combination strategies with phototherapy in cancer nanomedicine

Xie, Zhongjian; Fan, Taojian; An, Jusung; Choi, Wonseok; Duo, Yanhong; Ge, Yanqi; Zhang, Bin; Nie, Guohui; Xie, Ni; Zheng, Tingting; Chen, Yun; Zhang, Han; Kim, Jong Seung

doi:10.1039/d0cs00215a

Cited by 524 publications

(348 citation statements)

References 78 publications

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“…Our combination strategy provides a promising platform to enhance the therapeutic efficacy of aCD47 in solid tumours. Given the excellent biodegradability property of BP, it is possible that these inorganic NSs have potential in biomedical applications and clinical translation for combination with cancer immunotherapy to induce synergistic effects 78 .…”

Section: Discussionmentioning

confidence: 99%

Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy

Xie¹,

et al. 2020

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Here, we describe a combination strategy of black phosphorus (BP)-based photothermal therapy together with anti-CD47 antibody (aCD47)-based immunotherapy to synergistically enhance cancer treatment. Tumour resistance to immune checkpoint blockades in most cancers due to immune escape from host surveillance, along with the initiation of metastasis through immunosuppressive cells in the tumour microenvironment, remains a significant challenge for cancer immunotherapy. aCD47, an agent for CD47/SIRPα axis blockade, induces modest phagocytic activity and a low response rate for monotherapy, resulting in failures in clinical trials. We showed that BP-mediated ablation of tumours through photothermal effects could serve as an effective strategy for specific immunological stimulation, improving the inherently poor immunogenicity of tumours, which is particularly useful for enhancing cancer immunotherapy. BP in combination with aCD47 blockade activates both innate and adaptive immunities and promotes local and systemic anticancer immune responses, thus offering a synergistically enhanced effect in suppression of tumour progression and in inducing abscopal effects for inhibition of metastatic cancers. Our combination strategy provides a promising platform in which photothermal agents could help to enhance the therapeutic efficacy of immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy

Xie¹,

et al. 2020

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“…It could be combined with other bio-functional nanomaterials 73 , 74 . For the therapy of persistent tumors, combinatorial strategies of photothermal-chemotherapy, photothermal-immunotherapy, photothermal-gene therapy and photothermal-radiotherapy also bring about new opportunities addressing the challenges of single-mode phototherapy 75 . Most importantly, the photothermal effect can be used not only for therapy, but also for environmental applications 76 , 77 , such as photothermal evaporation for clean water production, photoinduced antimicrobial treatment, photocatalytic applications.…”

Section: Discussionmentioning

confidence: 99%

Continuous preparation of antimony nanocrystals with near infrared photothermal property by pulsed laser ablation in liquids

Kou

Wang

Liu

et al. 2020

Sci Rep

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Antimony nanocrystals (Sb NCs) are of interest in energy storage, catalysis and cancer therapy for its special physical, chemical and biomedical properties. However, methodology challenges still remain in preparation of colloidal Sb NCs, due to the restricted reaction solution systems, high temperature and time costing for common routes. Herein, size controllable colloidal Sb NCs were continuously prepared by pulsed laser ablation of Sb target in different solvents, owning to the metal nanodroplet explosive ejection and thermal evaporation mechanisms. These well dispersed and stable Sb NCs showed excellent photothermal property in the near-infrared-II window.

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“…The use of light in modern medicine was introduced in the 19 th century. Based on the advances in our understanding of the physical properties of light and light-matter interactions, medical technology has been developed in parallel 12 . A classic example of the early success of light-induced therapy was the treatment of lupus vulgaris with ultraviolet (UV) light, which was discovered by physician Niels Finsen, who won the Nobel Prize in Physiology or Medicine in 1903 for this discovery.…”

Section: Introductionmentioning

confidence: 99%

Phototherapy-based combination strategies for bacterial infection treatment

Wei¹,

Yang²,

Wang³

et al. 2020

Theranostics

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The development of nanomedicine is expected to provide an innovative direction for addressing challenges associated with multidrug-resistant (MDR) bacteria. In the past decades, although nanotechnology-based phototherapy has been developed for antimicrobial treatment since it rarely causes bacterial resistance, the clinical application of single-mode phototherapy has been limited due to poor tissue penetration of light sources. Therefore, combinatorial strategies are being developed. In this review, we first summarized the current phototherapy agents, which were classified into two functional categories: organic phototherapy agents ( e.g., small molecule photosensitizers, small molecule photosensitizer-loaded nanoparticles and polymer-based photosensitizers) and inorganic phototherapy agents ( e.g., carbo-based nanomaterials, metal-based nanomaterials, composite nanomaterials and quantum dots). Then the development of emerging phototherapy-based combinatorial strategies, including combination with chemotherapy, combination with chemodynamic therapy, combination with gas therapy, and multiple combination therapy, are presented and future directions are further discussed. The purpose of this review is to highlight the potential of phototherapy to deal with bacterial infections and to propose that the combination therapy strategy is an effective way to solve the challenges of single-mode phototherapy.

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Emerging combination strategies with phototherapy in cancer nanomedicine

Abstract: Based on the challenges in single-mode phototherapy, this review summarizes the significant research progress in combinatorial strategies with phototherapy.

Cited by 524 publications

References 78 publications

Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy

Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy

Continuous preparation of antimony nanocrystals with near infrared photothermal property by pulsed laser ablation in liquids

Phototherapy-based combination strategies for bacterial infection treatment

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