Stimuli-responsive luminescent hydrogels based on natural cellulose are emerging soft materials with potential applications because they simultaneously show unique luminescence properties, biocompatibility, biodegradability, and stimuliresponsiveness, and they particularly serve as functional biomaterials for bioimaging, biosensing, therapeutics, and so on. Herein, we provide a new method to prepare transparent, bulky, and multi-color luminescent hydrogels based on cellulose, ionic liquids, and lanthanide complexes (LnCs). Cellulose-based luminescent hydrogels were constructed first via dissolution−regeneration processes by dissolving cellulose in 1-allyl-3-methylimidazolium chloride (AmimCl) and then immersed in an aqueous solution of LnCs to fill the uniform porous structure of cellulose. The color-tunable emission colors ranging from red to green were emerged through regulating the molar ratio of Eu 3+ /Tb 3+ in LnCs. Additionally, the presence of Cu 2+ results in the luminescence "turn-off" process of resultant hydrogels by the naked eye through the photo-induced electron-transfer (PET) mechanism, including color and intensity, resulting in the selective recognition of Cu 2+ ions. Moreover, the strong coordination between glutathione (GSH) and Cu 2+ could destroy the PET process and restore the luminescence to "turn-on". Therefore, cellulose-based hydrogels could be utilized as biocompatible and biodegradable "off−on−off" luminescence switches in aqueous medium.