Emerging frontiers of antibiotics use and their impacts on the human gut microbiome

Kumari, Rekha; Yadav, Yasha; Misra, Richa; Das, Utpal; Adhikari, Upasana Das; Malakar, Pushkar; Dubey, Gyanendra P.

doi:10.1016/j.micres.2022.127127

Cited by 18 publications

(8 citation statements)

References 113 publications

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“…This disturbance in microbiota function may have lasting effects on host health, potentially contributing to the development of chronic conditions like IBD. Several drugs, including Cefazolin, Azithromycin, and Clarithromycin, examined by Kumari et al (2022), have shown similar effects on the gut microbiota, potentially elevating the risk of antibiotic-associated diarrhea and other gastrointestinal complications. Moreover, the overuse and misuse of antibiotics can lead to the emergence of antibiotic-resistant bacteria, adding complexity to the treatment of infections.…”

Section: Irrational Exposure Of Antibioticsmentioning

confidence: 99%

Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being

Meher,

Acharya,

Sahu

2024

Food Bioengineering

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The establishment of a healthy microbiota, particularly during infancy, profoundly influences psychological health and neurological function through the gut‐brain axis. This review delves into the intricate connections between probiotics, gut microbiome development, and their impact on neurological disorders. Biotics, live microorganisms with proven health benefits, have emerged as a promising intervention, particularly during critical developmental stages. Administering specific probiotic strains (Lactobacillus species and Bifidobacterium) in infancy has shown promise in preventing and alleviating gut disorders, with implications for psychological well‐being. The bidirectional communication along the gut‐brain axis underscores the potential of probiotics in influencing neurological outcomes, ranging from anxiety to neurodevelopmental disorders. Additionally, this review explores emerging food engineering techniques (microencapsulation, genome editing, fermentation, protein engineering, immobilization, etc.) employed in preparing probiotic‐based foods, ensuring the viability and targeted release of probiotics in the gastrointestinal tract.

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Section: Irrational Exposure Of Antibioticsmentioning

confidence: 99%

Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being

Meher,

Acharya,

Sahu

2024

Food Bioengineering

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“…La Asamblea instó a los Estados Miembros a que sumaran esfuerzos a través de elementos centrales como capacitaciones para la elaboración de políticas públicas, programas educativos, fortalecimiento de la legislación sobre la distribución de medicamentos sin prescripción por profesionales sanitarios calificados y sobre el impedimento en la fabricación, venta y distribución de antibióticos falsificados y la disminución del uso de antibióticos en animales para consumo humano. Estas acciones aceleran el desarrollo de la farmacorresistencia microbiana si no se llevan a cabo de forma adecuada ( 20 ).…”

Section: Materiales Y Métodosunclassified

Evolución histórica de la Organización Mundial de la Salud y la resistencia a los antimicrobianos

Vazquez‐Cabrera

Espinosa-Márquez

Cedillo-Ramírez

2023

Revista Panamericana De Salud Pública

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Objetivo. Mostrar la evolución de los lineamientos sobre políticas públicas en salud enfocadas en farmacorresistencia microbiana o resistencia a los antimicrobianos (RAM) que la Organización Mundial de la Salud (OMS) ha emitido desde 1948 hasta 2022. Además, se mencionan otras acciones gubernamentales relacionadas. Métodos. Se llevó a cabo una revisión detallada de los archivos de la Asamblea Mundial de la Salud y el Consejo Ejecutivo de la OMS. Se realizó un análisis textual de resoluciones sobre la RAM, que dan pauta al diseño de políticas y acciones gubernamentales para los Estados Miembros de la OMS. También se realizó una búsqueda sistemática en SCOPUS, Pubmed y literatura gris con categoría de análisis: políticas públicas en salud sobre la RAM. Resultados. La RAM se ha convertido en la mayor amenaza para la salud pública, y compromete el cumplimiento de los objetivos de desarrollo sostenible. Presentamos resoluciones de la OMS como evidencia de lineamientos para combatir la RAM. En consonancia, se menciona el enfoque “Una salud”, estrategias, iniciativas, planes y programas relacionados. Se identificó una brecha en la investigación y el desarrollo de antimicrobianos nuevos, que requiere un análisis más profundo. Conclusiones. La OMS ha realizado esfuerzos para combatir la RAM. Esto ha generado un desarrollo integral de políticas públicas en salud, para que los Estados Miembros las apliquen según la soberanía de sus gobiernos.

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“…Shigella sonnei ) [87,88,89 ▪ ], other commensals (e.g. nonpathogenic Neisseria species) [90 ▪ ,91,92], and microbiome [93,94]. Although reducing screening can improve antimicrobial stewardship [95 ▪ ], this may lead to some fear and concerns from the MSM community.…”

Section: Screening For Oropharyngeal Infectionsmentioning

confidence: 99%

STI pathogens in the oropharynx: update on screening and treatment

Chow,

Fairley,

Kong

2023

Current Opinion in Infectious Diseases

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Purpose of review The rise in antimicrobial resistance in several STI pathogens such as Neisseria gonorrhoeae has become a public health threat as only one first-line treatment remains. Reducing screening interval for gonorrhoea and chlamydia in high-prevalence populations has been proposed to address antimicrobial stewardship, but this remains controversial. This review aimed to revisit the epidemiology of infections at the oropharynx and review the current screening recommendations and treatment guidelines in different populations. Recent findings Emerging evidence suggests that the oropharynx is the primary anatomical site for gonorrhoea transmission but maybe not for chlamydia transmission. Most international guidelines recommend 3-monthly oropharyngeal gonorrhoea and chlamydia screening for high-prevalence populations (e.g. men who have sex with men) but not low-prevalence populations (e.g. heterosexuals) given the clinical and public health benefits of screening in low-prevalence populations are still unclear. Doxycycline remains the first-line treatment for oropharyngeal chlamydia in most guidelines. However, some countries have moved from dual therapy (ceftriaxone and azithromycin) to monotherapy (ceftriaxone) for oropharyngeal gonorrhoea treatment to address antimicrobial stewardship. Summary The transmission of gonorrhoea and chlamydia is still not fully understood. Further work will be required to evaluate the benefits and harms of reducing screening in high-prevalence populations.

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Emerging frontiers of antibiotics use and their impacts on the human gut microbiome

Cited by 18 publications

References 113 publications

Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being

Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being

Evolución histórica de la Organización Mundial de la Salud y la resistencia a los antimicrobianos

STI pathogens in the oropharynx: update on screening and treatment

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