Emerging functional nanomaterials for therapeutics

Xue, Xuejia; Wang, Feng; Liu, Xiaogang

doi:10.1039/c1jm11401h

Cited by 149 publications

(67 citation statements)

References 268 publications

(204 reference statements)

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“…NPs continue to be exploited in a variety of medical processes, including sensing, delivery, and as imaging or contrast agents [5][6][7]. It has been shown that NP size, shape, and surface properties strongly influence how they interact with cells, including the mechanism of cellular uptake [8].…”

Section: Introductionmentioning

confidence: 99%

Dynamic Cellular Uptake of Mixed-Monolayer Protected Nanoparticles

Carney

Mueller

et al. 2012

Biointerphases

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Nanoparticles (NPs) are gaining increasing attention for potential application in medicine; consequently, studying their interaction with cells is of central importance. We found that both ligand arrangement and composition on gold nanoparticles play a crucial role in their cellular internalization. In our previous investigation, we showed that 66-34OT nanoparticles coated with stripe-like domains of hydrophobic (octanethiol, OT, 34%) and hydrophilic (11-mercaptoundecane sulfonate, MUS, 66%) ligands permeated through the cellular lipid bilayer via passive diffusion, in addition to endo-/pino-cytosis. Here, we show an analysis of NP internalization by DC2.4, 3T3, and HeLa cells at two temperatures and multiple time points. We study four NPs that differ in their surface structures and ligand compositions and report on their cellular internalization by intracellular fluorescence quantification. Using confocal laser scanning microscopy we have found that all three cell types internalize the 66-34OT NPs more than particles coated only with MUS, or particles coated with a very similar coating but lacking any detectable ligand shell structure, or 'striped' particles but with a different composition (34-66OT) at multiple data points.

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Section: Introductionmentioning

confidence: 99%

Dynamic Cellular Uptake of Mixed-Monolayer Protected Nanoparticles

Carney

Mueller

et al. 2012

Biointerphases

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“…The rapid development of functional nanomaterials has been observed over the last few years (Xue et al 2011;Liu et al 2011;Limaye et al 2011;Yoo and Lee 2014). Nanomaterials are composed of particles having at least one dimension in the range of 1-100 nm (Henglein 1987).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, photophysical analysis, and in vitro cytotoxicity assessment of the multifunctional (magnetic and luminescent) core@shell nanomaterial based on lanthanide-doped orthovanadates

et al. 2015

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Rare earths orthovanadates (REVO 4 ) doped with luminescent lanthanide ions (Ln 3? ) play an important role as promising light-emitting materials. Gadolinium orthovanadate exhibits strong absorption of ultraviolet radiation and as a matrix doped with Eu 3? ions is well known for its efficient and intense red emission, induced by energy transfer from the VO 4 3-groups to Eu 3? ions. In the presented study, Fe 3 O 4 @SiO 2 @GdVO 4 :Eu 3? 5 % nanomaterial was investigated. The core@shell structures demonstrate attractive properties, such as higher thermal stability, enhanced water solubility, increased optical response, higher luminescence, longer decay times, and magnetic properties. Silica coating may protect nanocrystals from the surrounding environment. Therefore, such silica-covered nanoparticles (NPs) are successfully utilized in biomedical research. Multifunctional magnetic nanophosphors are very interesting due to their potential biomedical applications such as magnetic resonance imaging, hyperthermic treatment, and drug delivery. Therefore, the aim of our study was to investigate photophysical, chemical, and biological properties of multifunctional REVO 4 doped with Ln 3? . Moreover, the studied NPs did not affect erythrocyte sedimentation rate, cell membrane permeability, and morphology of human red blood cells.

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“…FRET has been reported for nanocomposites made with dyes attached by physisorption [40] by ligand exchange [25,41,42] and by covalent bonds [3,15,27]. Although all three techniques yield the desired short separation distance between dye and nanoparticle, the strong covalent bond is best able to withstand subsequent processing steps.…”

Section: Selection Of Optical Antenna and Matching With Sensitizing Ionmentioning

confidence: 99%

“…This process has potential in several applications, including diode-laserpumped solid-state lasers [1,2], luminescent bioassays [3][4][5][6][7][8], next-generation lighting [9], enhanced photovoltaic response [10,11], and imaging applications to expand the effective spectral range of silicon-based detectors [12,13].…”

Section: Introductionmentioning

confidence: 99%

Visible Discrimination of Broadband Infrared Light by Dye-Enhanced Upconversion in Lanthanide-Doped Nanocrystals

Dupuy

Allen

Williams

et al. 2014

Journal of Nanotechnology

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Optical upconversion of near infrared light to visible light is an attractive way to capture the optical energy or optical information contained in low-energy photons that is otherwise lost to the human eye or to certain photodetectors and solar cells. Until the recent application of broadband absorbing optical antennas, upconversion efficiency in lanthanide-doped nanocrystals was limited by the weak, narrow atomic absorption of a handful of sensitizer elements. In this work, we extend the role of the optical antenna to provide false-color, visible discrimination between bands of infrared radiation. By pairing different optical antenna dyes to specific nanoparticle compositions, unique visible emission is associated with different bands of infrared excitation. In one material set, the peak emission was increased 10-fold, and the width of the spectral response was increased more than 10-fold.

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Emerging functional nanomaterials for therapeutics

Cited by 149 publications

References 268 publications

Dynamic Cellular Uptake of Mixed-Monolayer Protected Nanoparticles

Dynamic Cellular Uptake of Mixed-Monolayer Protected Nanoparticles

Synthesis, photophysical analysis, and in vitro cytotoxicity assessment of the multifunctional (magnetic and luminescent) core@shell nanomaterial based on lanthanide-doped orthovanadates

Visible Discrimination of Broadband Infrared Light by Dye-Enhanced Upconversion in Lanthanide-Doped Nanocrystals

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