2019
DOI: 10.1111/ctr.13525
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Emerging fungal infections in solid organ transplant recipients: Guidelines of the American Society of Transplantation Infectious Diseases Community of Practice

Abstract: These updated AST‐IDCOP guidelines review the epidemiology, diagnosis, and management of emerging fungi after organ transplantation. Infections due to numerous generally innocuous fungi are increasingly recognized in solid organ transplant (SOT) recipients, comprising about 7%‐10% of fungal infections in this setting. Such infections are collectively referred to as emerging fungal infections and include Mucormycetes, Fusarium, Scedosporium, and dematiaceous fungi among others. The causative organisms are diver… Show more

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Cited by 57 publications
(38 citation statements)
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“…Infections in the immediate post-transplant period are either donor-derived or nosocomial [ 1 ]. Incidence of donor-derived infections in solid organ transplant recipients varies from 2.1%–23.4% [ 2 ] and can be classified as expected (known infection present in the donor) or unexpected [ 3 ]. The rate of transmission is also affected by the inoculum of pathogens, the organ transplanted, the use of different immunosuppressive agents and use of peri-operative antimicrobial prophylaxis [ 4 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Infections in the immediate post-transplant period are either donor-derived or nosocomial [ 1 ]. Incidence of donor-derived infections in solid organ transplant recipients varies from 2.1%–23.4% [ 2 ] and can be classified as expected (known infection present in the donor) or unexpected [ 3 ]. The rate of transmission is also affected by the inoculum of pathogens, the organ transplanted, the use of different immunosuppressive agents and use of peri-operative antimicrobial prophylaxis [ 4 ].…”
Section: Discussionmentioning
confidence: 99%
“…As in our case, blood and respiratory cultures are usually negative, and mucormycosis is usually diagnosed by direct examination or post-mortem culture of the affected tissue [ 9 ]. Transmission of mucormycetes from the organ itself is rare, but it is associated with high mortality [ 3 ]. Treatment includes early surgical debridement in combination with IV amphotericin-B [ 3 , 10 ].…”
Section: Discussionmentioning
confidence: 99%
“…Some patients may require treatment for months to years [ 16 , 17 ]. While not possible in all patients, reduction in immunosuppression should be considered as a fundamental adjunctive measure [ 18 ].…”
Section: Discussionmentioning
confidence: 99%
“…36 Patients who underwent SOT much more frequently developed cutaneous disease that may or may not involve multiple organ sites. [70][71][72] Fever is common but not universal, and may be accompanied by respiratory or neurologic symptoms, skin manifestations such as nodular rash, or ulcerative lesions, and, rarely, frank sepsis. 18,50 Marked eosinophilia may be observed and is associated with Curvularia, the most common causes of allergic disease.…”
Section: Disseminated Diseasementioning
confidence: 99%