Emerging Klebsiella pneumoniae Isolates Coproducing KPC-2 and VIM-1 Carbapenemases

Detection of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae producing NDM-1 in Lebanon

“…One case of a K. pneumoniae producing OXA-48 was reported in an Egyptian patient hospitalized in France [11]. Reports from Greece revealed class B, VIM types -1,-2,-12, -19; class A, KPC-2 and class D, OXA-48 [8][9][10]. In Israel, reports described the presence of KPC-2 and KPC-3 [14].…”

“…The introduction of such resistant strains, particularly those carrying the NDM-1 gene, constitutes an alarming threat. Reports on carbapenem resistant E. coli and K. pneumoniae have been published from different countries in the region including Turkey [1,[5][6][7], Greece [8][9][10], Egypt [11], Saudi Arabia [12], Oman [13], Israel [14], and Iraq [15].…”

First Report of a Pseudomonas aeruginosa Isolate Coharboring KPC and VIM Carbapenemases

“…Since the first identification of KPC-producing (15) and VIM-producing (16) Pseudomonas aeruginosa isolates in Colombia, their interhospital clonal dissemination throughout the country has been followed by our group. To the best of our knowledge, the copresence of VIM and KPC has not been reported in species other than Klebsiella pneumoniae (4,8,10,11,14,17), and the only report of a P. aeruginosa isolate coharboring KPC and a metallo-␤-lactamase (IMP-8) was recently published in Puerto Rico (7). Hence, we report for the first time in the world a P. aeruginosa clinical isolate that coharbors VIM and KPC.…”

Relación clonal y detección del gen blaKPC en cepas de Klebsiella pneumoniae resistentes a carbapenémicos, en un hospital de Venezuela

“…En este sentido, se ha reportado que la co-presencia de serinocarbapenemasas y metalo-β-lactamasas, interfiere con la detección fenotípica de KPC. En una investigación 29 , se encontró que el ensayo con AFB era inefectivo en cepas de K. pneumoniae con co-producción del gen bla KPC y bla VIM atribuyendo este falso negativo con AFB, al efecto enmascarante de la metalo-β-lactamasa tipo VIM. Esto podría explicar la negatividad obtenida con AFB para la cepa con fenotipo de metalo-β-lactamasa hallada en la presente investigación; sin embargo, se tendrían que realizar pruebas moleculares para detectar el gen bla VIM en esa cepa.…”