Emerging implications of nanotechnology on cancer diagnostics and therapeutics

Cuenca, Alex G.; Jiang, Huabei; Hochwald, Steven N.; Delano, Matthew J.; Cance, William G.; Grobmyer, Stephen R.

doi:10.1002/cncr.22035

Cited by 422 publications

(279 citation statements)

References 78 publications

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“…It is likely that further developments in MR imaging technology, and nanotechnology will lead to the expansion of the application of MR to loco-regional staging and treatment of breast cancer (18,19).…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging for axillary staging in patients with breast cancer

Mortellaro

Marshall

Singer

et al. 2009

Magnetic Resonance Imaging

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107

103

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Purpose:To determine the utility of MRI for assessing axillary lymph node status in patients with breast cancer. Materials and Methods:A consecutive series of patients who underwent breast MR before surgical management of breast cancer with axillary sampling between 2005 and 2007 were identified. MRs were evaluated for the number of nodes, contrast kinetics, nodal area, and number of nodes with no fatty hilum. Data were analyzed in the context of final breast pathology, sentinel lymph node status, and axillary nodal status. Correlations were analyzed using Kendall's -b test. Reported P values are one-sided.Results: Fifty-six females (median ϭ 58 years) were studied. Sentinel lymph nodes (SLN) were positive in 15/56 patients (27%). All SLN ϩ patients (n ϭ 15) had completion axillary dissection. Extent of nodal disease was 1 (n ϭ 3), 2 (n ϭ 4), Ͼ2 (n ϭ 8). Presence of any axillary lymph node with no fatty hilum and the number of nodes with no fatty hilum on MR significantly correlated with pathologic node positivity (P ϭ 0.04); while kinetics, node number, and node size did not correlate. Conclusion:Breast MR may be useful in the assessment of axillary nodes in patients with breast cancer.

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Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging for axillary staging in patients with breast cancer

Mortellaro

Marshall

Singer

et al. 2009

Magnetic Resonance Imaging

Self Cite

107

103

View full text Add to dashboard Cite

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“…Nanotechnology in cancer is used to describe the communication of nanoscale devices with the cellular and molecular mechanisms exactly related to tumor, for both diagnostic and therapeutic purposes. Nanoparticles have very tiny size, nanoparticles surface is adapted for conjugation with the therapeutic medications can enter the cancer cells with great level of specificity [71,74]. The skill to identify several tumors at an initial stage in its clinical sequence has the ability to develop patient outcomes in relations of morbidity and mortality, as well as novel Nano-biosensors, have enhanced sensitivity and specificity compared with traditional testing methods of cancer.…”

Section: Cancer Nanotechnology: Definition and Applicationmentioning

confidence: 99%

Liposomes and Nanotechnology in Drug Development: Focus On Pancreatic Cancer

Malik¹,

Jin²,

Raheem³

et al. 2017

JGPLD

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Pancreatic cancer usually has high morbidity and mortality and rests one of the most challenging cancers to treat. 5 years survival rate is less than 6 percent overall for people with pancreatic cancer, because of very late diagnosis and absence of effective treatment. In a western world, pancreatic tumor is the fourth most common cause of death in a western world. The pancreatic tumor needs selective delivery of drugs to target cells, with no side effects is major goals of the recent investigations for the real treatment of the pancreatic tumor. Medication which targets pancreatic tumor cells specially and carriers which deliver medications to specific cells which are quickly dividing, development of these kind drugs is considered as magic for the management of pancreatic cancer. In latest years, liposomes and nanotechnology can show a vital character in the treatment of pancreatic tumor. Liposomes contain multiple characteristics, such as the ability to protect the material from degradation, the capacity for encapsulating many materials and capability for delivering materials intracellularly fusion with plasma membrane. Nanoparticles as a carrier offer a new style of delivery of the medications to target cells of a tumor and allow drugs for the binding to tumor cell membrane, to cytoplasmic and to nuclear receptor sites. It delivers high medication concentrations to specific cells with few side effects to other normal tissues. The general importance of this evaluation is to increase overall understanding of development of the therapeutic nanomedicine for the treatment of pancreatic tumors, agents delivered by nanoliposomes, liposomal nanomedicine in targeting cancer and safety issues.

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“…Nanoimaging uses various techniques like para-magnetic iron oxide nanoparticles 29 for the study of in-vivo molecular events and molecules manipulation, particularly by magnetic resonance imaging.…”

Section: Role Of Nanotechnology In In-vivo Diagnosismentioning

confidence: 99%