Emerging Mumps Infection

Rubin, Steven A.; Kennedy, Richard B.

doi:10.1097/inf.0000000000001182

Cited by 30 publications

(30 citation statements)

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“…These values may be attributable to sex-based immune responses and hormonal influences in addition to genetic and epigenetic factors [25,26]. The accumulation of susceptible young persons who are brought together in high-density settings can lead to high levels of infection and an increased risk of exposure [27,28]. Mumps outbreaks were recently reported in the US and in Europe, both with high MMR vaccine coverage [27,29].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China

Zhou

Song

ZhiYing³

et al. 2020

Journal of Immunology Research

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Background. From 2005 to 2016, the prevention and control of mumps in China have undergone three stages of transition. These include the use of MuCV as a self-supported vaccine, the introduction of one-dose MMR to the Expanded Program on Immunization (EPI), and the administration of two-dose MuCV following supplementary immunization activities (SIAs) using MM. Here, using surveillance data, we assessed the epidemiology of mumps during the three stages. Methods. Children in Quzhou of China born from 2005 to 2016 and registered in the Zhejiang Provincial Immunization Information System (ZJIIS) were included. We analyzed the epidemic data and calculated incidence and MuCV coverage via birth cohorts. Results. The average incidence of mumps in 2005-2006, 2007-2010, and 2011-2016 was 51.57, 41.02, and 12.53 per 100,000 individuals, respectively. The highest incidence was in children aged 6-14 years from 2005-2016, of which the majority were school students (67.84%). Approximately 90% of the reported outbreaks occurred in school children (primary school/middle school). The seasonal characteristics of mumps were less obvious from 2011 to 2016. The coverage of one-dose MMR in the 2005 birth cohort was 71.38%. For the 2006-2010 birth cohort, the coverage of one-dose MuCV was 96.82% and the coverage of two-dose MuCV was 17.68%. The children born from 2011 to 2016 were only free vaccinated with MMR; the coverage of one-dose MuCV was 99.10%. The mumps incidence in the three birth cohorts significantly declined (X2=805.90, P<0.001 for trend). Except the children less than two years old, the mumps incidence for the children born from 2006 to 2010 was higher than that for the children born from 2011 to 2016. Conclusion. The mumps incidence significantly declined following the introduction of one-dose MMR. The SIA using MM led to a rapid reduction of mumps cases. Therefore, we recommend a two-dose MuCV routine immunization schedule and improved vaccination coverage.

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Section: Discussionmentioning

confidence: 99%

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China

Zhou

Song

ZhiYing³

et al. 2020

Journal of Immunology Research

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“…The clinical pictures of mumps virus (MuV) infection is characterized by pain and swelling of the parotid glands, but can involve various other tissues and organs [2]. It can cause serious complications including encephalitis, meningitis, orchitis, myocarditis, pancreatitis, and nephritis [2,3]. Although mumps is a benign disease, often with complete recovery within a few weeks after being infected, long-term outcomes, such as seizures, cranial nerve palsies, hydrocephalus, and deafness, can occur [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…It can cause serious complications including encephalitis, meningitis, orchitis, myocarditis, pancreatitis, and nephritis [2,3]. Although mumps is a benign disease, often with complete recovery within a few weeks after being infected, long-term outcomes, such as seizures, cranial nerve palsies, hydrocephalus, and deafness, can occur [3,4]. Due to its benign clinical picture, mumps has been somewhat neglected compared with other infectious diseases (e.g., measles).…”

Section: Introductionmentioning

confidence: 99%

“…Previous report showed that 70% of patients with known vaccination history had received two doses of measles, mumps, and rubella (MMR) vaccine prior to illness [5]. Compared to mumps, cases of measles and rubella rarely occur in person with two doses of MMR vaccine, suggesting some factors of mumps vaccine influences its effectiveness [3]. Therefore, understanding the characteristics of MuV epidemiology, pathogenesis, and vaccine is important to protect against the spread of MuV infection.…”

Section: Introductionmentioning

confidence: 99%

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Current Status of Mumps Virus Infection: Epidemiology, Pathogenesis, and Vaccine

Chang²,

Chen

2020

IJERPH

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Mumps is an important childhood infectious disease caused by mumps virus (MuV). We reviewed the epidemiology, pathogenesis, and vaccine development of mumps. Previous studies were identified using the key words “mumps” and “epidemiology”, “pathogenesis” or “vaccine” in MEDLINE, PubMed, Embase, Web of Science, and Google Scholar. We excluded the articles that were not published in the English language, manuscripts without abstracts, and opinion articles from the review. The number of cases caused by MuV decreased steeply after the introduction of the mumps vaccine worldwide. In recent years, a global resurgence of mumps cases in developed countries and cases of aseptic meningitis caused by some mumps vaccine strains have renewed the importance of MuV infection worldwide. The performance of mumps vaccination has become an important issue for controlling mumps infections. Vaccine development and routine vaccination are still effective measures to globally reduce the incidence of mumps infections. During outbreaks, a third of MMR vaccine is recommended for groups of persons determined by public authorities.

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“…Multiple studies have demonstrated that mumps Ab responses, including neutralizing Ab titers, decline significantly over time [6][7][8][9]. Neutralizing Ab is associated with protection, but no specific titer has been identified as a correlate of protection [10]. While ELISAs are commonly used to assess mumps immunity, they detect both neutralizing and nonneutralizing Ab; thus, there is less confidence in the assay's ability to assess functional antibody and protection.…”

Section: Introductionmentioning

confidence: 99%

Differential durability of immune responses to measles and mumps following MMR vaccination

Kennedy

Ovsyannikova

Thomas

et al. 2019

Vaccine

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The development and widespread use of mumps vaccine resulted in a dramatic and sustained decrease in the incidence of mumps disease; however, since 2000, an increase in the size and number of mumps outbreaks in the United States and other countries has sparked renewed interest in the durability of mumps-specific immunity elicited by mumps vaccination. The most likely explanation for mumps cases in previously immunized persons may be secondary vaccine failure, or waning immunity. In the current study, we examined changes in markers of measles and mumps immunity at two timepoints, approximately 7 and 17 years after two-dose MMR-II® vaccination, in a cohort of 98 healthy adults.

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Emerging Mumps Infection

Cited by 30 publications

References 11 publications

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China

Current Status of Mumps Virus Infection: Epidemiology, Pathogenesis, and Vaccine

Differential durability of immune responses to measles and mumps following MMR vaccination

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