Emerging nanostructured materials for musculoskeletal tissue engineering

Peng, Haisheng; Liu, Xunpei; Wang, Ran; Feng, Jia; Dong, Liang; Wang, Qun

doi:10.1039/c4tb00344f

Cited by 67 publications

(47 citation statements)

References 324 publications

(356 reference statements)

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“…nanostructure materials, 14 which can be further modied using various dopants with the aim of changing their surface properties. Among such dopant substances, synthetic polyanions have been observed to exhibit interesting biological properties.…”

Section: Introductionmentioning

confidence: 99%

Stem cell differentiation on conducting polyaniline

et al. 2015

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Polyaniline is a promising conducting polymer with broad application potential in biomedicine. Its medical use, however, requires both biocompatibility and suitable physico-chemical and surface properties. The microstructure, electrical properties, and surface characteristics of polyaniline salt, polyaniline base, and polyaniline deposited with biologically active poly(2-acrylamido-2-methyl-1-propanesulfonic acid) were revealed using atomic force microscopy, contact angle measurements, and Raman spectroscopy. As conducting polymers can be preferentially applied in tissue engineering of heart and nervous tissues, the cardiomyogenesis in pure cardiomyocytes derived from embryonic stem cells and neurogenesis in neural progenitors isolated from embryonal 13 dpc brain were further investigated. The results show that neither cardiomyogenesis nor neurogenesis were influenced by any of the tested polyaniline films.However, the most favorable cell behaviour was observed on pristine polyaniline base; therefore, polyaniline in pristine forms without any further modification can be applied in a variety of biomedical fields.

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Section: Introductionmentioning

confidence: 99%

Stem cell differentiation on conducting polyaniline

et al. 2015

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“…Classes of nanomaterials used in musculoskeletal bioengineering include natural polymers, synthetic polymers, metallic materials, inorganic materials, and nanocomposite materials [62]. The biocompatible natural polymers chitin and chitosan, derived from the crustacean exoskeleton, are of interest as a scaffold in tissue engineering these structures, and they share structural similarity to glycosaminoglycans, a key component of bone ECM [63,64].…”

Section: Bone Cartilage and Soft Tissuementioning

confidence: 99%

Whole-Organ Tissue Engineering: No Longer Just a Dream

Wrenn

Weiss

2016

Curr Pathobiol Rep

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Purpose of Review The true potential of the field of transplant surgery remains limited due to shortages of available transplantable allografts and, following transplantation, acute and chronic rejection with need for lifelong immune suppression. An alternative approach is to bioengineer organs to be utilized in vivo, replacing diseased or malfunctioning human organs. This revolutionary step in medicine could have virtually unlimited therapeutic potential. Recent Findings Multiple strategies have been used to replicate functional transplantable organs without deleterious host immune response. Common approaches include the use of decellularized tissue scaffolds and of 3D bioprinting. Continuing challenges include engraftment and maturation of recipient cells, and long-term tissue viability and function. Summary We will review in brief the history of the field and the progress to date with multiple organ systems, highlighting our personal experience in lung regeneration. Finally, we will discuss the challenges that lie ahead to reach the dream of fully functional and transplantable bioengineered organs.

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“…Xian and Ming [9] reported that glucose oxidase is effective in electron transfer process of enzyme adsorbed to sphere-nanostructured conductive polymer=metal oxide composite. The complexes having reduction=oxidation are efficient electron transfer mediators between the active center of glucose oxidase [10,11].…”

Section: Introductionmentioning

confidence: 99%

Research on the Repeated Use of Novel Ferrocene-Tagged Nanomaterial for Determination of Glucose

Yetim

Özkan

Daniş

et al. 2015

International Journal of Polymeric Materials and Polymeric Biom

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A good novel double ferrocene-tagged nanomaterial is designed for glucose determination and its recycling stability. Double Ferrocene-tagged nanomaterial displays higher catalytic activity toward the glucose oxidation than non-ferrocene-tagged nanomaterial. In this study novel nanoparticles including double ferrocene, N-f2-[Bis(2-aminoethyl)amino]ethylgaminomethyl-polystyrene (2AEPS) and ferrocene aldehyde (Fc) have been synthesized by means of condensation and investigated the enzymatic properties of glucose oxidase enzyme (GOD) immobilized on there. Double ferrocene-tagged nanomaterial-GOD shows high reusability and storage capacity and fast incubation time determination of glucose. 2AEPSFc-GOD retains more than 15% of the initial activity after forty five successive cycles, which is a perfect performance.

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Emerging nanostructured materials for musculoskeletal tissue engineering

Abstract: This review summarizes the recent developments in the preparation and applications of nanostructured materials for musculoskeletal tissue engineering.

Cited by 67 publications

References 324 publications

Stem cell differentiation on conducting polyaniline

Stem cell differentiation on conducting polyaniline

Whole-Organ Tissue Engineering: No Longer Just a Dream

Research on the Repeated Use of Novel Ferrocene-Tagged Nanomaterial for Determination of Glucose

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