Emerging Novel Approaches for the Enhanced Delivery of Natural Products for the Management of Neurodegenerative Diseases

Bandiwadekar, Akshay; Jose, Jobin; Khayatkashani, Maryam; Habtemariam, Solomon; Kashani, Hamid Reza Khayat; Nabavi, Seyed Mohammad

doi:10.1007/s12031-021-01922-7

Cited by 30 publications

(18 citation statements)

References 178 publications

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“…Accordingly, they have biological effects on diverse mechanisms, such as epigenetic modifications, modulation of signal transduction and metabolic pathways, and regulation of antioxidant enzyme activity [ 54 , 55 ]. In support of their advantageous effects, several data have been reported in literature, particularly regarding their anticancer activities [ 56 ] and their ability to delay or escape the onset and progression of CVD [ 57 ] or other chronic pathologies [ 58 ]. The phytochemicals with antioxidant-rich properties comprise the polyphenols, flavonoids, iso-flavonoids, anthocyanidins, phytoestrogens, terpenoids, carotenoids, limonoids, phytosterols, glucosinolates and fibres.…”

Section: From the Experimental Aspects To Translational Medicine: Ant...mentioning

confidence: 99%

Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms

et al. 2022

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Aorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data. No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus, their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress (OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these aspects by revealing some OS pathways as potential biomarkers, their underlying limitations, and potential solutions and approaches, as well as some potential treatments.

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Section: From the Experimental Aspects To Translational Medicine: Ant...mentioning

confidence: 99%

Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms

et al. 2022

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“…Flavonoids, including hesperetin, are known to decrease the neuroinflammation involved in the progression of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis as well as MS, but not to directly inhibit the degeneration of neuronal and glial cells [33,34]. Specifically, it has been reported that flavonoids block the secretion of inflammatory cytokines such as TNFα and IL-6 from microglial cells and delay the progression of neurodegenerative disorders [33,34]. It has also been reported that they act as antioxidant molecules to reduce the levels of oxidative stress through reactive oxygen species (ROSs)-scavenging mechanisms as antioxidant molecules [35,36].…”

Section: Discussionmentioning

confidence: 99%

Hesperetin, a Citrus Flavonoid, Ameliorates Inflammatory Cytokine-Mediated Inhibition of Oligodendroglial Cell Morphological Differentiation

Nishino

Fujiki

Sato

et al. 2022

Neurology International

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Oligodendrocytes (oligodendroglial cells) are glial cells that wrap neuronal axons with their differentiated plasma membranes called myelin membranes. In the pathogenesis of inflammatory cytokine-related oligodendroglial cell and myelin diseases such as multiple sclerosis (MS), typical inflammatory cytokines tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) are thought to contribute to the degeneration and/or progression of the degeneration of oligodendroglial cells and, in turn, the degeneration of naked neuronal cells in the central nervous system (CNS) tissues. Despite the known involvement of these inflammatory cytokines in disease progression, it has remained unclear whether and how TNFα or IL-6 affects the oligodendroglial cells themselves or indirectly. Here we show that TNFα or IL-6 directly inhibits morphological differentiation in FBD-102b cells, which are differentiation models of oligodendroglial cells. Their phenotype changes were supported by the decreased expression levels of oligodendroglial cell differentiation and myelin marker proteins. In addition, TNFα or IL-6 decreased phosphorylation levels of Akt kinase, whose upregulation has been associated with promoting oligodendroglial cell differentiation. Hesperetin, a flavonoid mainly contained in citrus fruit, is known to have neuroprotective effects. Hesperetin might also be able to resolve pre-illness conditions, including the irregulated secretion of cytokines, through diet. Notably, the addition of hesperetin into cells recovered TNFα- or IL-6-induced inhibition of differentiation, as supported by increased levels of marker protein expression and phosphorylation of Akt kinase. These results suggest that TNFα or IL-6 itself contributes to the inhibitory effects on the morphological differentiation of oligodendroglial cells, possibly providing information not only on their underlying pathological effects but also on flavonoids with potential therapeutic effects at the molecular and cellular levels.

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“…In recent years, many studies surrounded the effect of berberine in central nervous system disease, including Alzheimer’s disease, Parkinson’s disease, Huntington disease, etc. ( Jiang et al, 2011 ; Kim et al, 2014 ; Jiang et al, 2015b ; Bandiwadekar et al, 2021 ). Berberine has proven its protective role on oxidative stress, neuroinflammation, neuroprotection, etc.…”

Section: Therapeutic Effects Of Berberine On Neurodegenerative Diseasementioning

confidence: 99%

“…Although a considerable new research progress has been made in Alzheimer’s disease research, the pathogenesis remains unclear. Current typical histopathological changes in Alzheimer’s disease include Aβ plaques and tau tangles, the accumulation of these proteins leads to neuroinflammation and normal dysfunction, leading to neuronal death ( Ameen and Michniak-Kohn, 2017 ; Bandiwadekar et al, 2021 ; Ye et al, 2021 ). The hypotheses on the pathogenesis of Alzheimer’s disease include cholinergic hypothesis, amyloid toxicity hypothesis, oxidative stress hypothesis, etc.…”

Section: Therapeutic Effects Of Berberine On Neurodegenerative Diseasementioning

confidence: 99%

“…( Ye et al, 2009 ; Guo et al, 2021 ). At present, the therapies of Alzheimer’s disease include stem cell therapy, gene therapy, and chemotherapy, but these therapies have limitations inevitably such as inefficient and neurotoxicity ( Bandiwadekar et al, 2021 ). At the same time, natural compounds have better compatibility with the human body and have fewer side effects.…”

Section: Therapeutic Effects Of Berberine On Neurodegenerative Diseasementioning

confidence: 99%

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Berberine: A Promising Treatment for Neurodegenerative Diseases

et al. 2022

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Berberine, as a natural alkaloid compound, is characterized by a diversity of pharmacological effects. In recent years, many researches focused on the role of berberine in central nervous system diseases. Among them, the effect of berberine on neurodegenerative diseases has received widespread attention, for example Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and so on. Recent evidence suggests that berberine inhibits the production of neuroinflammation, oxidative, and endoplasmic reticulum stress. These effects can further reduce neuron damage and apoptosis. Although the current research has made some progress, its specific mechanism still needs to be further explored. This review provides an overview of berberine in neurodegenerative diseases and its related mechanisms, and also provides new ideas for future research on berberine.

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Emerging Novel Approaches for the Enhanced Delivery of Natural Products for the Management of Neurodegenerative Diseases

Cited by 30 publications

References 178 publications

Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms

Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms

Hesperetin, a Citrus Flavonoid, Ameliorates Inflammatory Cytokine-Mediated Inhibition of Oligodendroglial Cell Morphological Differentiation

Berberine: A Promising Treatment for Neurodegenerative Diseases

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