2019
DOI: 10.1016/j.cophys.2019.03.010
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Emerging novel mechanisms of action for nitric oxide in cancer progression

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Cited by 10 publications
(4 citation statements)
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“…13 C-NMR (101 MHz, CDCl 3 ) δ 169.3, 168.4, 157.9, 151.8, 138.3, 138.0, 137.9, 137.3, 135.9, 134.8, 130.2, 129.9, 129.8, 129.3, 129.2, 128.6, 128.5, 128.4, 126.9, 120.7, 120.2, 110.6, 67.2, 51.7, 28.7, and 21.0. MS (IE, 70 eV) m/z](%): 568 (M + -NH-t-butyl, 0.1); 540 (40); 345 (71); 316 (33); 196 (54); 121 (100); 91 (39); 77 (22); and 57 (14). HRMS (ESI+): calculated for.…”
Section: N-(1-(tert-butylaminocarbonyl)-1-phenylmethyl)-n-(4-methylph...mentioning
confidence: 99%
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“…13 C-NMR (101 MHz, CDCl 3 ) δ 169.3, 168.4, 157.9, 151.8, 138.3, 138.0, 137.9, 137.3, 135.9, 134.8, 130.2, 129.9, 129.8, 129.3, 129.2, 128.6, 128.5, 128.4, 126.9, 120.7, 120.2, 110.6, 67.2, 51.7, 28.7, and 21.0. MS (IE, 70 eV) m/z](%): 568 (M + -NH-t-butyl, 0.1); 540 (40); 345 (71); 316 (33); 196 (54); 121 (100); 91 (39); 77 (22); and 57 (14). HRMS (ESI+): calculated for.…”
Section: N-(1-(tert-butylaminocarbonyl)-1-phenylmethyl)-n-(4-methylph...mentioning
confidence: 99%
“…This depends mainly on its intracellular concentration but also on the microenvironment, cell type, and the exposure time to ·NO. Some studies suggest that at high levels this radical can exert its antitumor activity through various mechanisms [ 22 , 23 ]. Among the structures capable of releasing ·NO, furoxans are a widely used example in medicinal chemistry [ 24 ], especially in the search for anticancer agents [ 25 ].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, overexpression of NOSTRIN curtailed cell invasion and gemcitabine-induced apoptotic cell death in human pancreatic cancer cell line [ 15 ]. NOSTRIN’s ability to sequester eNOS and consequently its dampening effect on NO production by endothelial cells has been implicated in cancer progression [ 16 ]. Interestingly, combined use of NOS inhibitors with 5-fluorouracil showed enhanced inhibition of cell proliferation and migration in CRC cell lines [ 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, when inappropriate and excessive NO production occurs, NO takes on a pathological role, being associated with the development of different diseases, such as neurological and inflammatory diseases, atherosclerosis, pain and cancer. [2][3][4] NO is generated as a product of the enzymatic oxidation of l-Arg to l-Cit, by the heme-containing enzyme nitric oxide synthase (NOS). [5] There are three distinct isoforms of NOS: the endothelial NOS (eNOS) and neuronal NOS (nNOS) are constitutive and calcium dependent" and catalyze the production of low and pulsating NO levels.…”
Section: Introductionmentioning
confidence: 99%