Emerging prospects of integrated bioanalytical systems in neuro-behavioral toxicology

Bai, Yutao; Henry, Jason; Campana, Olivia; Wlodkowic, Donald

doi:10.1016/j.scitotenv.2020.143922

Cited by 17 publications

(10 citation statements)

References 83 publications

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“…Neurotoxins are chemical substances external to the body, synthetic in general, that cause structural, biochemical, and functional damage to the central nervous system, peripheral nervous system, and sensory organs (Bai et al, 2020). Therefore, exposure to neurotoxins can cause sensory, motor, and neurocognitive disorders (Fishbein et al, 2019;Pérez-Fernández et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Neurobehavioral, Neuromotor, and Neurocognitive Effects in Agricultural Workers and Their Children Exposed to Pyrethroid Pesticides: A Review

Lucero

Muñoz-Quezada

2021

Front. Hum. Neurosci.

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In recent years, pyrethroids have emerged as a less toxic alternative to eliminate insect pests. However, some animal studies and studies with children show that these pesticides are toxic and lead to neurobehavioral effects similar to other pesticides, such as organophosphates. The purpose of this review was to systematize the epidemiological scientific evidence about the neurobehavioral, neuromotor, and neurocognitive effects in agricultural workers and their children exposed to pyrethroid pesticides. We conducted two searches (with different terms) in PubMed and Scopus databases, including articles in Spanish and English language on the effects of occupational exposure to pyrethroid pesticides associated with neurobehavioral, neuromotor, and neurocognitive functioning of agricultural workers and their children. There were no filters by year, and the search included studies till march 2021. To develop the search, we followed the recommendations contained in the PRISMA guidelines and the PICO strategy. The results show that in 66.6% of the studies reviewed (8 of 12 studies), agricultural workers or their children occupationally exposed to pyrethroid pesticides have a higher risk of presenting difficulties in their neurocognitive, neuromotor, or neurobehavioral performance, mainly associated with attention, processing speed (linked to hand-eye coordination), and motor coordination. There are still few studies that address this issue. However, the quality of most of the research conducted (83% intermediate or high quality) confirms the risk for neurobehavioral health in agricultural workers due to occupational exposure to pyrethroids. More research is required evaluating the exposure to pyrethroids, including biomarkers and validated neurobehavioral and neuromotor tests, in addition to evaluating the effect of simultaneous exposure to other hazardous pesticides. Assuming that the use of pyrethroids is increasing considerably and faster than the scientific evidence, it is suggested as a precautionary principle to regulate, more strictly, the sale of pyrethroids and other pesticides.

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Section: Introductionmentioning

confidence: 99%

Neurobehavioral, Neuromotor, and Neurocognitive Effects in Agricultural Workers and Their Children Exposed to Pyrethroid Pesticides: A Review

Lucero

Muñoz-Quezada

2021

Front. Hum. Neurosci.

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“…Microfluidic analysis is a new subject in the field of chemical analysis, medical diagnosis, safety detection, sample treatment, and micro-reaction [13][14][15][16][17][18][19][20][21]. It is a comprehensive science integrating chip manufacturing, microfluidic mechanics, material transport physics, chemical reaction dynamics, spectroscopy, and modern informatics [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Smartphone-coupled three-layered paper-based microfluidic chips demonstrating stereoscopic capillary-driven fluid transport towards colorimetric detection of pesticides

Chen

Yang

et al. 2022

Anal Bioanal Chem

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The existence of pesticide residues in the hydrosphere, biosphere, and anthroposphere can cause acute or chronic diseases and deteriorate the environment. Therefore, efficient detection of pesticide residues is of great significance to prevent food poisoning, control food pollution, and protect human lives by recognizing their distribution and concentration. Herein, a novel smartphone-coupled three-layered paper-based microfluidic chip is proposed as a facile platform to detect the pesticides. The stereoscopic capillary-driven fluid transport is enabled by the three-layered microfluidic chip configuration. The detection mechanism is based on the enzyme inhibition reaction and the chromatic reaction. The detection results are obtained by a smartphone and figured out by colorimetric quantitative analysis. Taking advantages of the above merits, we demonstrate the utilization of this smartphone-coupled three-layered paper-based microfluidic chip for the effective analysis of typical pesticides (profenofo and methomyl). The linear ranges of profenofo and methomyl are 0.27-2.1 μmol L −1 and 0.14-1.85 μmol L −1 , respectively. The corresponding limits of detection in the chips are 55 nM and 34 nM, respectively. The paper-based chips are also highly cost-effective with a total cost of 0.082 ¥ per piece. It can be anticipated that this technique will open new avenues for the mass fabrication of paper-based microfluidic chips and provide state-of-the-art methods in the field of analytical chemistry.

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“…Surprisingly, only a handful of studies have so far explored rapid multidimensional behavioral tests batteries utilizing a combination of sensorimotor assays, e.g., startle, phototaxis, thermotaxis, and chemotaxis during predictive eco-neurotoxicity testing [ 3 , 4 , 6 , 7 ]. Compared to simple and unstimulated locomotory behaviors, such as alterations in spontaneous swimming speed, the analysis of more complex sensorimotor reactions can provide enhanced insights with ecological and neurotoxicological relevance [ 3 , 4 , 8 ]. There is a broad range of modes of action amongst chemical compounds and thus there is also a broad hierarchy of neurobehavioral endpoints that can be impacted upon exposure [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In this regard, there is still a particular paucity of data on wider applications and incorporation of thermotactic behavioral tests in aquatic toxicology [ 3 , 6 , 8 ]. This is mostly related to a lack of automated analytical systems that could be used for rapid thermal preference behavioral biotests [ 8 ]. Thermotaxis is characterized by directional movement toward (positive thermotaxis) or away from (negative thermotaxis) from a region of perceived optimal or noxious temperatures, respectively [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Sensory-Motor Perturbations in Larval Zebrafish (Danio rerio) Induced by Exposure to Low Levels of Neuroactive Micropollutants during Development

Henry

Bai

Kreuder

et al. 2022

IJMS

Self Cite

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Due to increasing numbers of anthropogenic chemicals with unknown neurotoxic properties, there is an increasing need for a paradigm shift toward rapid and higher throughput behavioral bioassays. In this work, we demonstrate application of a purpose-built high throughput multidimensional behavioral test battery on larval stages of Danio rerio (zebrafish) at 5 days post fertilization (dpf). The automated battery comprised of the established spontaneous swimming (SS), simulated predator response (SPR), larval photomotor response (LPR) assays as well as a new thermotaxis (TX) assay. We applied the novel system to characterize environmentally relevant concentrations of emerging pharmaceutical micropollutants including anticonvulsants (gabapentin: 400 ng/L; carbamazepine: 3000 ng/L), inflammatory drugs (ibuprofen: 9800 ng/L), and antidepressants (fluoxetine: 300 ng/L; venlafaxine: 2200 ng/L). The successful integration of the thermal preference assay into a multidimensional behavioral test battery provided means to reveal ibuprofen-induced perturbations of thermal preference behaviors upon exposure during embryogenesis. Moreover, we discovered that photomotor responses in larval stages of fish are also altered by the as yet understudied anticonvulsant gabapentin. Collectively our results demonstrate the utility of high-throughput multidimensional behavioral ecotoxicity test batteries in prioritizing emerging risks associated with neuroactive drugs that can perturb neurodevelopment. Moreover, we showcase the added value of thermotaxis bioassays for preliminary screening of emerging contaminants.

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Emerging prospects of integrated bioanalytical systems in neuro-behavioral toxicology

Cited by 17 publications

References 83 publications

Neurobehavioral, Neuromotor, and Neurocognitive Effects in Agricultural Workers and Their Children Exposed to Pyrethroid Pesticides: A Review

Neurobehavioral, Neuromotor, and Neurocognitive Effects in Agricultural Workers and Their Children Exposed to Pyrethroid Pesticides: A Review

Smartphone-coupled three-layered paper-based microfluidic chips demonstrating stereoscopic capillary-driven fluid transport towards colorimetric detection of pesticides

Sensory-Motor Perturbations in Larval Zebrafish (Danio rerio) Induced by Exposure to Low Levels of Neuroactive Micropollutants during Development

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