Emerging Role of Redox-Active Nanoceria in Cancer Therapeutics via Oxidative Stress

Thakur, Neelam; Das, Joydeep; Sil, Parames C.

doi:10.1007/978-981-16-1247-3_117-1

Cited by 3 publications

(4 citation statements)

References 60 publications

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“…The as-developed nanosensor exhibited remarkable performance in glucose sensing, displaying a broader response range, low detection limits equal to 99 mM, and a rapid response time of five seconds, alongside a high sensitivity of 0.032 µA•m/M•cm 2 . Their research's results indicated that (4,5). These enzymes, in turn, facilitate the reversal of insulin resistance and facilitate the entry of glucose transporter 4 into the cell's plasma membrane (6,7,8).…”

Section: Mgo-based Biosensors Towards Diabetes Detection and Treatmentmentioning

confidence: 99%

“…This field focuses on crafting nanoparticles (NPs) and harnessing their potential in areas like biomedicine, sensing, and catalysis [1]. The significance of NPs stems from their unique properties, such as small size, adaptable shapes, substantial surface area compared to volume, and outstanding magnetic, electronic, optical, and mechanical traits [2][3][4][5]. Yet, the distinctiveness of each nanoparticle primarily relies on the utilized synthesis method [6].…”

Section: Introductionmentioning

confidence: 99%

“…Firstly, MgO nanoparticles adhere to the surface of affected cells(1,2,3). Subsequently, they discharge Mg 2+ and O 2-ions, initiating the activation of internal enzymes(4,5). These enzymes, in turn, facilitate the reversal of insulin resistance and facilitate the entry of glucose transporter 4 into the cell's plasma membrane(6,7,8).…”

mentioning

confidence: 99%

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Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Gatou,

Skylla,

Dourou

et al. 2024

Crystals

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In recent times, there has been considerable interest among researchers in magnesium oxide (MgO) nanoparticles, due to their excellent biocompatibility, stability, and diverse biomedical uses, such as antimicrobial, antioxidant, anticancer, and antidiabetic properties, as well as tissue engineering, bioimaging, and drug delivery applications. Consequently, the escalating utilization of magnesium oxide nanoparticles in medical contexts necessitates the in-depth exploration of these nanoparticles. Notably, existing literature lacks a comprehensive review of magnesium oxide nanoparticles’ synthesis methods, detailed biomedical applications with mechanisms, and toxicity assessments. Thus, this review aims to bridge this gap by furnishing a comprehensive insight into various synthetic approaches for the development of MgO nanoparticles. Additionally, it elucidates their noteworthy biomedical applications as well as their potential mechanisms of action, alongside summarizing their toxicity profiles. This article also highlights challenges and future prospects for further exploring MgO nanoparticles in the biomedical field. Existing literature indicates that synthesized magnesium oxide nanoparticles demonstrate substantial biocompatibility and display significant antibacterial, antifungal, anticancer, and antioxidant properties. Consequently, this review intends to enhance readers’ comprehension regarding recent advancements in synthesizing MgO nanoparticles through diverse approaches and their promising applications in biomedicine.

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Section: Mgo-based Biosensors Towards Diabetes Detection and Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Gatou,

Skylla,

Dourou

et al. 2024

Crystals

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“…Further, nanoparticles with intrinsic diagnostic and/or therapeutic properties can be incorporated as an intrinsic feature of the system. Since nanoceria exhibits intrinsic anticancer properties − and has been employed for the therapeutic management of cancer, the present work aims at exploring the potential for nanoceria as the therapeutic component of the theranostic system. A diagnostic component, which is a fluorophore-tagged ligand that is targeted at the epidermal growth factor receptor (EGFR), is conjugated with nanoceria to formulate the theranostic agent.…”

Section: Introductionmentioning

confidence: 99%

Theranostic Activity of Ceria-Based Nanoparticles toward Parental and Metastatic Melanoma: 2D vs 3D Models

Johnson

Kopecky

Koshy

et al. 2023

ACS Biomater. Sci. Eng.

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The time interval between the diagnosis of tumor in a patient and the initiation of treatment plays a key role in determining the survival rates. Consequently, theranostics, which is a combination of diagnosis and treatment, can be expected to improve survival rates. Early detection and immediate treatment initiation are particularly important in the management of melanoma, where survival rates decrease considerably after metastasis. The present work reports for the first time the application of fluorescein isothiocyanate (FITC)tagged epidermal growth factor receptor (EGFR)-functionalized ceria nanoparticles, which exhibit intrinsic reactive oxygen species (ROS)mediated anticancer effects, for the EGFR-targeted diagnosis and treatment of melanoma. The theranostic activity was demonstrated using two-dimensional (2D) and three-dimensional (3D) models of parental and metastatic melanoma. Confocal imaging studies confirm the diagnostic activity of the system. The therapeutic efficiency was evaluated using cell viability studies and ROS measurements. The ROS elevation levels are compared across the 2D and 3D models. Significant enhancement in the generation of cellular ROS and absence in mitochondrial ROS are observed in the 2D models. In contrast, significant elevations in both ROS types are observed for the 3D models, which are significantly higher for the metastatic spheroids than the parental spheroids, thus indicating the suitability of this nanoformulation for the treatment of metastatic melanoma.

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Folic acid-functionalized cerium oxide nanoparticles as smart nanocarrier for pH-responsive and targeted delivery of Morin in breast cancer therapy

Thakur

Sadhukhan²,

Kundu³

et al. 2022

Inorganic Chemistry Communications

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Emerging Role of Redox-Active Nanoceria in Cancer Therapeutics via Oxidative Stress

Abstract: Cancer is one of the leading causes of death throughout the world. Various conventional therapeutic techniques, such as surgery, chemotherapy, radiation therapy, immunotherapy, and hormone therapy, have been implemented to cure

Cited by 3 publications

References 60 publications

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Theranostic Activity of Ceria-Based Nanoparticles toward Parental and Metastatic Melanoma: 2D vs 3D Models

Folic acid-functionalized cerium oxide nanoparticles as smart nanocarrier for pH-responsive and targeted delivery of Morin in breast cancer therapy

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