Emerging roles of circular RNAs in neuropathic pain

Xu, Derong; Ma, Xuexiao; Sun, Chong; Han, Jialuo; Zhou, Chuanli; Chan, Matthew T.V.; Wu, William Ka Kei

doi:10.1111/cpr.13139

Cited by 15 publications

(12 citation statements)

References 66 publications

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“… 28 , 62 Recently, emerging studies found that circRNAs play important roles in developing and maintaining neuropathic pain. 13 , 63 For instance, Zhang et al found 22 DE circRNAs in rat spinal cord on days 7 and 14 following SNL. And they proved that the up-regulated CircAnks1a in the spinal cord of rats contributes to the hypersensitivity in the paw induced by SNL injury.…”

Section: Discussionmentioning

confidence: 99%

Interactions Among Non-Coding RNAs and mRNAs in the Trigeminal Ganglion Associated with Neuropathic Pain

Fang¹,

Liao²,

Tang³

et al. 2022

JPR

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Background Recent studies have demonstrated the contribution of non-coding RNAs (ncRNAs) to neuropathic pain. However, the expression profile of ncRNAs in the trigeminal ganglion (TG) and their functional mechanism underlying trigeminal neuropathic pain are still unclear. Methods In the present study, the trigeminal neuropathic pain model induced by chronic constriction injury of the infraorbital nerve (CCI-ION) was used to study the expression profile and potential regulatory mechanism of miRNAs, lncRNAs, circRNAs, and mRNAs in the TG by RNA-sequencing (RNA-seq) and bioinformatics analysis. CCI-ION mice suffered from mechanical allodynia from 3 days to 28 days after surgery. Results The RNA-seq results discovered 67 miRNAs, 216 lncRNAs, 14 circRNAs, 595 mRNAs, and 421 genes were differentially expressed (DE) in the TG of CCI-ION mice 7 days after surgery. And 39 DEGs were known pain genes. Besides, 5 and 35 pain-related DE mRNAs could be targeted by 6 DE miRNAs and 107 DE lncRNAs, respectively. And 23 pain-related DEGs had protein–protein interactions (PPI) with each other. GO analysis indicated membrane-related cell components and binding-related molecular functions were significantly enriched. KEGG analysis showed that nociception-related signaling pathways were significantly enriched for DE ncRNAs and DEGs. Finally, the competing endogenous RNA (ceRNA) regulatory network of DE lncRNA/DE circRNA-DE miRNA-DE mRNA existed in the TG of mice with trigeminal neuropathic pain. Conclusion Our findings demonstrate ncRNAs are involved in the development of trigeminal neuropathic pain, possibly through the ceRNA mechanism, which brings a new bright into the study of trigeminal neuropathic pain and the development of novel treatments targeting ncRNAs.

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Section: Discussionmentioning

confidence: 99%

Interactions Among Non-Coding RNAs and mRNAs in the Trigeminal Ganglion Associated with Neuropathic Pain

Fang¹,

Liao²,

Tang³

et al. 2022

JPR

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“…circRNAs have also been involved in neuropathic pain (reviewed elsewhere: [ 94 ]). Recent preclinical studies using the CCI model in rats have identified imbalances in different circRNAs.…”

Section: Non-coding Rnas and Painmentioning

confidence: 99%

“… * Note there are other ncRNA involved in nociceptive processing, which are not included in this table as have been covered in recent reviews, see [ 91 , 92 , 93 , 94 , 95 ]. …”

Section: Figurementioning

confidence: 99%

DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain

Irfan

Febrianto

Sharma

et al. 2022

IJMS

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While about half of the population experience persistent pain associated with tissue damages during their lifetime, current symptom-based approaches often fail to reduce such pain to a satisfactory level. To provide better patient care, mechanism-based analgesic approaches must be developed, which necessitates a comprehensive understanding of the nociceptive mechanism leading to tissue injury-associated persistent pain. Epigenetic events leading the altered transcription in the nervous system are pivotal in the maintenance of pain in tissue injury. However, the mechanisms through which those events contribute to the persistence of pain are not fully understood. This review provides a summary and critical evaluation of two epigenetic mechanisms, DNA methylation and non-coding RNA expression, on transcriptional modulation in nociceptive pathways during the development of tissue injury-associated pain. We assess the pre-clinical data and their translational implication and evaluate the potential of controlling DNA methylation and non-coding RNA expression as novel analgesic approaches and/or biomarkers of persistent pain.

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“…Neuropathic pain results from damage or disease to the somatosensory nervous system, characterized by allodynia, hyperalgesia, and spontaneous pain ( Xu et al, 2021 ). At the same time, the transmission of long-term nociceptive signals induces plasticity changes in the structure and function of some brain regions such as the medial prefrontal cortex (mPFC) ( Mecca et al, 2021 ), ACC ( Smith et al, 2021 ), amygdala ( Murugappan et al, 2021 ), and hippocampus ( Toledo et al, 2021 ), which are also involved in the regulation of emotion and cognitive functions, so that nociceptive signals not only include pain components but also cover emotion-related components in the brain ( De Ridder et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

Wen

et al. 2022

Front. Mol. Neurosci.

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Neuropathic pain is often accompanied by anxiety and depression-like manifestations. Many studies have shown that alterations in synaptic plasticity in the anterior cingulate cortex (ACC) play a critical role, but the specific underlying mechanisms remain unclear. Previously, we showed that cAMP response element-binding protein (CREB) in the dorsal root ganglion (DRG) acts as a transcription factor contributing to neuropathic pain development. At the same time, brain-derived neurotrophic factor (BDNF), as important targets of CREB, is intricate in neuronal growth, differentiation, as well as the establishment of synaptic plasticity. Here, we found that peripheral nerve injury activated the spinal cord and ACC, and silencing the ACC resulted in significant relief of pain sensitivity, anxiety, and depression in SNI rats. In parallel, the CREB/BDNF pathway was activated in the spinal cord and ACC. Central specific knockdown and peripheral non-specific inhibition of CREB reversed pain sensitivity and anxiodepression induced by peripheral nerve injury. Consequently, we identified cingulate CREB/BDNF as an assuring therapeutic method for treating neuropathic pain as well as related anxiodepression.

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Emerging roles of circular RNAs in neuropathic pain

Cited by 15 publications

References 66 publications

Interactions Among Non-Coding RNAs and mRNAs in the Trigeminal Ganglion Associated with Neuropathic Pain

Interactions Among Non-Coding RNAs and mRNAs in the Trigeminal Ganglion Associated with Neuropathic Pain

DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain

The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

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