Emerging Roles of lncRNAs in the Formation and Progression of Colorectal Cancer

He, Qinglian; Long, Jiali; Yin, Yuting; Li, Yuling; Xue, Lijun; Li, Ziqi; Zhu, Wei

doi:10.3389/fonc.2019.01542

Cited by 35 publications

(33 citation statements)

References 117 publications

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“…Previous evidences indicate that ncRNAs could play a critical role in the regulation of cellular processes such as cell growth, apoptosis, and cancer progression and metastasis in colorectal cancer [11,12]. The combination of Pivot and survival analysis detected the ncRNAs which regulated crosstalk modules across the stages of COAD.…”

Section: Discussionmentioning

confidence: 97%

“…Given the high incidence of global COAD cases and increased mortality due to distant metastasis, it is of paramount importance to identify the novel regulatory pathways involved in COAD growth and metastasis. In recent years, a growing amount of research has shown that not only some important genes but also ncRNAs play key roles in the process of COAD progression [11,12]. Presently, most of the researches only focus on certain gene families or miRNA families [11].…”

Section: Discussionmentioning

confidence: 99%

“…The increased sensitivity of experimental assays has revealed that ncRNAs, especially miRNA and lncRNA, impact a variety of important biological processes via posttranscriptional regulation [13,15]. A lot of evidence suggests that miRNA and lncRNA play important roles in COAD progression [11,12]. To identify gene modules and their essential ncRNAs that are likely to play an important role in COAD malignant progression, an integrated approach was adopted to construct COADrelated ncRNA posttranscriptional regulatory networks.…”

Section: Coad-related Gene Modules and Their Ncrnamentioning

confidence: 99%

“…The increased sensitivity of experimental assays had revealed that noncoding RNAs (ncRNAs) have impacts on a variety of important biological processes, particularly microRNA (miRNA) and long noncoding RNA (lncRNA) [8][9][10]. Numerous studies have demonstrated that miRNA and lncRNA play a vital biological role in regulating COAD processes [11,12]. MiRNAs are 18 nucleotides to 25 nucleotides in length.…”

Section: Introductionmentioning

confidence: 99%

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Contributions of Gene Modules Regulated by Essential Noncoding RNA in Colon Adenocarcinoma Progression

et al. 2020

BioMed Research International

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Noncoding RNAs (ncRNAs), especially microRNA (miRNA) and long noncoding RNA (lncRNA), have an impact on a variety of important biological processes during colon adenocarcinoma (COAD) progression. This includes chromatin organization, transcriptional and posttranscriptional regulation, and cell-cell signaling. The aim of this study is to identify the ncRNA-regulated modules that accompany the progression of COAD and to analyze their mechanisms, in order to screen the potential prognostic biomarkers for COAD. An integrative molecular analysis was carried out to identify the crosstalks of gene modules between different COAD stages, as well as the essential ncRNAs in the posttranscriptional regulation of these modules. 31 ncRNA regulatory modules were found to be significantly associated with overall survival in COAD patients. 17 out of the 31 modules (in which ncRNAs played essential roles) had improved the predictive ability for COAD patient survival compared to only the mRNAs of those modules, which were enriched in the core cancer hallmark pathways with closer interactions. These suggest that the ncRNAs’ regulatory modules not only exhibit close relation to COAD progression but also reflect the dynamic significant crosstalk of genes in the modules to the different malignant extent of COAD.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Coad-related Gene Modules and Their Ncrnamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Contributions of Gene Modules Regulated by Essential Noncoding RNA in Colon Adenocarcinoma Progression

et al. 2020

BioMed Research International

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“…Recent researches have indicated that many lncRNAs exert an important role in almost all physiological and pathological processes, including embryonic stem cell, carcinogenesis, and cancer metastasis. 3,4 The lncRNAs have been reported to function as oncogenes or tumor suppressor gene, participating in CRC tumorigenesis and progression. For example, a report from Xu et al showed that lncRNA MIR17HG drove tumor development and metastasis in colorectal cancer cells via enhancing the expression of NF-κB/RELA.…”

Section: Introductionmentioning

confidence: 99%

LncRNA SNHG22 Sponges miR-128-3p to Promote Progression of Colorectal Cancer through Upregulating E2F3

Jianning¹,

Wang²,

Xuyang³

et al. 2020

Preprint

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Background: Long non-coding RNA (lncRNA) termed small nucleolar RNA host gene 22 (SNHG22) has been reported as a crucial regulator in several types of human cancers. In this study, we aimed to evaluate the function and mechanism of SNHG22 in colorectal cancer (CRC) progression. Methods: Quantitative RT-PCR (qRT-PCR) was used to detect the expression of SNHG22 in adenoma, tumor tissues (TTs), and adjacent nontumorous tissues (ANTs). The biological behaviors of SNHG22 in CRC cell lines were explored both in vitro (CCK-8 assay, flow cytometry, wound scratch, and transwell assays) and in vivo (nude mouse xenograft model). The interaction between SNHG22 and miR-128-3p, and the target genes of miR-128-3p were explored by online tools, qRT-PCR, western blot, and dual-luciferase reporter assay. Results: SNHG22 expression was gradually upregulated in ANTs, adenoma, and TTs. High expression levels of SNHG22 were significantly related to advanced clinicopathological factors and worse survival in patients with CRC. SNHG22 knockdown markedly prohibited CRC cell proliferation, migration, and invasion; and drove cell apoptosis in vitro; and hindered tumor growth in vivo. Mechanistic investigation showed that SNHG22 could bind to microRNA-128-3p (miR-128-3p) and attenuate its inhibitory effects on the expression levels and activity of E2F3. Rescue experiments exhibited that miR-128-3p inhibition or E2F3 upregulation can offset the functions of SNHG22 knockdown in CRC cells. Conclusion: Our findings support the existence of an interactive regulatory network of SNHG22, miR-128-3p, and E2F3 in CRC cell lines, indicating that the SNHG22/miR-128-3p/E2F3 axis is a novel diagnostic and therapeutic target in CRC.

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c‐JUN‐induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression

Liang

Liu

2023

Cell Biology International

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Colorectal cancer (CRC) is one of the most common human malignancies due to its invasiveness and metastasis. Recent studies revealed the pivotal roles of long noncoding RNAs (lncRNAs) in tumorigenesis and progressions of various tumors. However, the biological roles and molecular mechanisms of long intergenic noncoding RNA 00174 (LINC00174) in human CRC remain unclear. Here, we report that LINC00174 expression was higher in human CRC tissues and cell lines than in adjacent normal tissues and a colon epithelial cell line (FHC). High expression of LINC00174 was positively correlated with poor overall and disease‐free survival in patients with CRC. Loss‐ and gain‐of‐function of LINC00174 demonstrated its critical roles in promoting cell proliferation, apoptosis resistance, migration, and invasion of CRC cells in vitro. Moreover, overexpression of LINC00174 enhanced tumor growth in vivo. Mechanistic experiments revealed that LINC00174 could bind to microRNA (miR)−2467‐3p and augment the expression and function of ubiquitin‐specific peptidase 21 (USP21). Rescue assays found that miR‐2467‐3p inhibition can offset the actions of LINC00174 or USP21 knockdown in CRC cells. Additionally, transcriptional factor c‐JUN transcriptionally activated LINC00174 expression and mediated LINC00174‐induced malignant phenotypes of CRC cell lines. Totally, our findings shed light on a new therapeutic strategy in modulating LINC00174/miR‐2467‐3p, which may interfere with the expression of USP21, and revealed that LINC00174 could be a new therapeutic target or prognostic marker in CRC.

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Emerging Roles of lncRNAs in the Formation and Progression of Colorectal Cancer

Cited by 35 publications

References 117 publications

Contributions of Gene Modules Regulated by Essential Noncoding RNA in Colon Adenocarcinoma Progression

Contributions of Gene Modules Regulated by Essential Noncoding RNA in Colon Adenocarcinoma Progression

LncRNA SNHG22 Sponges miR-128-3p to Promote Progression of Colorectal Cancer through Upregulating E2F3

c‐JUN‐induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression

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