Emerging roles of RETINOBLASTOMA-RELATED proteins in evolution and plant development

Gutzat, Ruben; Borghi, Loris; Gruissem, Wilhelm

doi:10.1016/j.tplants.2011.12.001

Cited by 89 publications

(89 citation statements)

References 99 publications

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“…Interestingly, comparative genomic studies of cell cycle genes revealed an expansion of the D-type cyclins in V. carteri compared with C. reinhardtii . D-type cyclins in plants and animals are activating subunits for cyclin-dependent kinases that regulate retinoblastomarelated proteins through phosphorylation (Gutzat et al 2012). Whether the expanded D-cyclin repertoire in V. carteri enabled modifications of the embryonic cell division program or contributes to germ-soma differentiation remains to be determined.…”

Section: Multicellular Innovations In the Volvocine Lineage Are Modifmentioning

confidence: 99%

Green Algae and the Origins of Multicellularity in the Plant Kingdom

Umen

2014

Cold Spring Harbor Perspectives in Biology

121

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The green lineage of chlorophyte algae and streptophytes form a large and diverse clade with multiple independent transitions to produce multicellular and/or macroscopically complex organization. In this review, I focus on two of the best-studied multicellular groups of green algae: charophytes and volvocines. Charophyte algae are the closest relatives of land plants and encompass the transition from unicellularity to simple multicellularity. Many of the innovations present in land plants have their roots in the cell and developmental biology of charophyte algae. Volvocine algae evolved an independent route to multicellularity that is captured by a graded series of increasing cell-type specialization and developmental complexity. The study of volvocine algae has provided unprecedented insights into the innovations required to achieve multicellularity.

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Section: Multicellular Innovations In the Volvocine Lineage Are Modifmentioning

confidence: 99%

Green Algae and the Origins of Multicellularity in the Plant Kingdom

Umen

2014

Cold Spring Harbor Perspectives in Biology

121

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“…The Arabidopsis pRB ortholog is the RETINOBLASTOMA-RELATED (RBR) protein (Gutzat et al, 2012). As in animals, RBR inhibits cell cycle progression by interacting with an E2F transcription factor homolog (Gutzat et al, 2012;Magyar et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

RETINOBLASTOMA-RELATED Protein Stimulates Cell Differentiation in theArabidopsisRoot Meristem by Interacting with Cytokinin Signaling

Perilli¹,

Pérez-Pérez

Mambro³

et al. 2013

The Plant Cell

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Maintenance of mitotic cell clusters such as meristematic cells depends on their capacity to maintain the balance between cell division and cell differentiation necessary to control organ growth. In the Arabidopsis thaliana root meristem, the antagonistic interaction of two hormones, auxin and cytokinin, regulates this balance by positioning the transition zone, where mitotically active cells lose their capacity to divide and initiate their differentiation programs. In animals, a major regulator of both cell division and cell differentiation is the tumor suppressor protein RETINOBLASTOMA. Here, we show that similarly to its homolog in animal systems, the plant RETINOBLASTOMA-RELATED (RBR) protein regulates the differentiation of meristematic cells at the transition zone by allowing mRNA accumulation of AUXIN RESPONSE FACTOR19 (ARF19), a transcription factor involved in cell differentiation. We show that both RBR and the cytokinin-dependent transcription factor ARABIDOPSIS RESPONSE REGULATOR12 are required to activate the transcription of ARF19, which is involved in promoting cell differentiation and thus root growth.

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“…Subsequently, E2F/DP-dependent transcription of cell cycle genes promotes S phase entry and cell cycle progression. Because of its central role in controlling the transcription of cell cycle genes, RB serves as a convergence point for regulating the cell cycle in response to internal and external mitogenic signals (Nakagami et al, 2002;Stevaux et al, 2002;Cobrinik, 2005;Dimova and Dyson, 2005;Wikenheiser-Brokamp, 2006;Jullien et al, 2008;van den Heuvel and Dyson, 2008;Borghi et al, 2010;Henriques et al, 2010;Johnston et al, 2010;Chen et al, 2011;Gutzat et al, 2011Gutzat et al, , 2012Weimer et al, 2012). Recent studies also provide evidence that RB depletion causes metabolic reprogramming and suggest that the RB pathway in animals exerts part of its effect on cell proliferation through the control of Gln metabolism (Nicolay et al, 2013;Reynolds et al, 2014).…”

mentioning

confidence: 99%

Defects in a New Class of Sulfate/Anion Transporter Link Sulfur Acclimation Responses to Intracellular Glutathione Levels and Cell Cycle Control

et al. 2014

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We previously identified a mutation, suppressor of mating type locus3 15-1 (smt15-1), that partially suppresses the cell cycle defects caused by loss of the retinoblastoma tumor suppressor-related protein encoded by the MAT3 gene in Chlamydomonas reinhardtii. smt15-1 single mutants were also found to have a cell cycle defect leading to a small-cell phenotype. SMT15 belongs to a previously uncharacterized subfamily of putative membrane-localized sulfate/anion transporters that contain a sulfate transporter domain and are found in a widely distributed subset of eukaryotes and bacteria. Although we observed that smt15-1 has a defect in acclimation to sulfur-limited growth conditions, sulfur acclimation (sac) mutants, which are more severely defective for acclimation to sulfur limitation, do not have cell cycle defects and cannot suppress mat3. Moreover, we found that smt15-1, but not sac mutants, overaccumulates glutathione. In wild-type cells, glutathione fluctuated during the cell cycle, with highest levels in mid G1 phase and lower levels during S and M phases, while in smt15-1, glutathione levels remained elevated during S and M. In addition to increased total glutathione levels, smt15-1 cells had an increased reduced-to-oxidized glutathione redox ratio throughout the cell cycle. These data suggest a role for SMT15 in maintaining glutathione homeostasis that impacts the cell cycle and sulfur acclimation responses.

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Emerging roles of RETINOBLASTOMA-RELATED proteins in evolution and plant development

Cited by 89 publications

References 99 publications

Green Algae and the Origins of Multicellularity in the Plant Kingdom

Green Algae and the Origins of Multicellularity in the Plant Kingdom

RETINOBLASTOMA-RELATED Protein Stimulates Cell Differentiation in theArabidopsisRoot Meristem by Interacting with Cytokinin Signaling

Defects in a New Class of Sulfate/Anion Transporter Link Sulfur Acclimation Responses to Intracellular Glutathione Levels and Cell Cycle Control

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