Emerging strains of porcine epidemic diarrhoea virus (PEDv) in Mexico

Reveles-Félix, Saúl; Carreón-Nápoles, Rosalba; Mendoza-Elvira, Susana; Quintero-Ramírez, Víctor; García-Sánchez, Juvencio; Martínez-Bautista, Rebeca; Saavedra‐Montañez, Manuel; Mosqueda, Juan; Sánchez‐Betancourt, José Ivan

doi:10.1111/tbed.13426

Cited by 20 publications

(11 citation statements)

References 11 publications

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“… 2015 ; Niederwerder and Hesse 2018 ; Reveles-Felix et al. 2020 ). According to the most recent prevalence study in China, the average PEDV-positive rate in pigs from 39 farms across eight provinces, primarily in Hunan, was 38.0% (Tan et al.…”

Section: Occurrence and Epidemiologymentioning

confidence: 99%

Swine coronaviruses (SCoVs) and their emerging threats to swine population, inter-species transmission, exploring the susceptibility of pigs for SARS-CoV-2 and zoonotic concerns

Thakor

Dinesh

Manikandan

et al. 2022

Veterinary Quarterly

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Swine coronaviruses (SCoVs) are one of the most devastating pathogens affecting the livelihoods of farmers and swine industry across the world. These include transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine respiratory coronavirus (PRCV), porcine hemagglutinating encephalomyelitis virus (PHEV), swine acute diarrhea syndrome coronavirus (SADS-CoV), and porcine delta coronavirus (PDCoV). Coronaviruses infect a wide variety of animal species and humans because these are having single stranded-RNA that accounts for high mutation rates and thus could break the species barrier. The gastrointestinal, cardiovascular, and nervous systems are the primary organ systems affected by SCoVs. Infection is very common in piglets compared to adult swine causing high mortality in the former. Bat is implicated to be the origin of all CoVs affecting animals and humans. Since pig is the only domestic animal in which CoVs cause a wide range of diseases; new coronaviruses with high zoonotic potential could likely emerge in the future as observed in the past. The recently emerged severe acute respiratory syndrome coronavirus virus-2 (SARS-CoV-2), causing COVID-19 pandemic in humans, has been implicated to have animal origin, also reported from few animal species, though its zoonotic concerns are still under investigation. This review discusses SCoVs and their epidemiology, virology, evolution, pathology, wildlife reservoirs, interspecies transmission, spill-over events and highlighting their emerging threats to swine population. The role of pigs amid ongoing SARS-CoV-2 pandemic will also be discussed. A thorough investigation should be conducted to rule out zoonotic potential of SCoVs and to design appropriate strategies for their prevention and control.

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Section: Occurrence and Epidemiologymentioning

confidence: 99%

Swine coronaviruses (SCoVs) and their emerging threats to swine population, inter-species transmission, exploring the susceptibility of pigs for SARS-CoV-2 and zoonotic concerns

Thakor

Dinesh

Manikandan

et al. 2022

Veterinary Quarterly

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“…The infection affects pigs of all ages, with piglets less than one week old being the most affected (100% morbidity and mortality). Although the virus does not affect human health, it causes significant economic losses to the pig breeding industry [ 1 ]. Current treatment is primarily aimed at diarrhea controlling.…”

Section: Introductionmentioning

confidence: 99%

Predicted 3D model of the M protein of Porcine Epidemic Diarrhea Virus and analysis of its immunogenic potential

et al. 2022

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The membrane protein M of the Porcine Epidemic Diarrhea Virus (PEDV) is the most abundant component of the viral envelope. The M protein plays a central role in the morphogenesis and assembly of the virus through protein interactions of the M-M, M-Spike (S) and M-nucleocapsid (N) type. The M protein is known to induce protective antibodies in pigs and to participate in the antagonistic response of the cellular antiviral system coordinated by the type I and type III interferon pathways. The 3D structure of the PEDV M protein is still unknown. The present work exposes a predicted 3D model of the M protein generated using the Robetta protocol. The M protein model is organized into a transmembrane and a globular region. The obtained 3D model of the PEDV M protein was compared with 3D models of the SARS-CoV-2 M protein created using neural networks and with initial machine learning-based models created using trRosetta. The 3D model of the present study predicted four linear B-cell epitopes (RSVNASSGTG and KHGDYSAVSNPSALT peptides are noteworthy), six discontinuous B-cell epitopes, forty weak binding and fourteen strong binding T-cell epitopes in the CV777 M protein. A high degree of conservation of the epitopes predicted in the PEDV M protein was observed among different PEDV strains isolated in different countries. The data suggest that the M protein could be a potential candidate for the development of new treatments or strategies that activate protective cellular mechanisms against viral diseases.

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“…In 2013, an outbreak occurred in pigs of all ages in the United States, with the incidence among suckling piglets being as high as 90% [ 11 , 12 ]. Subsequently, PEDV was prevalent in Canada, Mexico, and other counties [ 13 , 14 , 15 , 16 ]. Existing studies have reported that PEDV can exist in transported feeds for a long time, which increases the possibility of its transmission [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Triacetyl Resveratrol Inhibits PEDV by Inducing the Early Apoptosis In Vitro

Wang

Liu

et al. 2022

IJMS

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PEDV represents an ancient Coronavirus still causing huge economic losses to the porcine breeding industry. Resveratrol has excellent antiviral effects. Triacetyl resveratrol (TCRV), a novel natural derivative of resveratrol, has been recently discovered, and its pharmacological effects need to be explored further. This paper aims to explore the relationship between PEDV and TCRV, which offers a novel strategy in the research of antivirals. In our study, Vero cells and IPEC-J2 cells were used as an in vitro model. First, we proved that TCRV had an obvious anti-PEDV effect and a strong inhibitory effect at different time points. Then, we explored the mechanism of inhibition of PEDV infection by TCRV. Our results showed that TCRV could induce the early apoptosis of PEDV-infected cells, in contrast to PEDV-induced apoptosis. Moreover, we observed that TCRV could promote the expression and activation of apoptosis-related proteins and release mitochondrial cytochrome C into cytoplasm. Based on these results, we hypothesized that TCRV induced the early apoptosis of PEDV-infected cells and inhibited PEDV infection by activating the mitochondria-related caspase pathway. Furthermore, we used the inhibitors Z-DEVD-FMK and Pifithrin-α (PFT-α) to support our hypothesis. In conclusion, the TCRV-activated caspase pathway triggered early apoptosis of PEDV-infected cells, thereby inhibiting PEDV infections.

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Emerging strains of porcine epidemic diarrhoea virus (PEDv) in Mexico

Cited by 20 publications

References 11 publications

Swine coronaviruses (SCoVs) and their emerging threats to swine population, inter-species transmission, exploring the susceptibility of pigs for SARS-CoV-2 and zoonotic concerns

Swine coronaviruses (SCoVs) and their emerging threats to swine population, inter-species transmission, exploring the susceptibility of pigs for SARS-CoV-2 and zoonotic concerns

Predicted 3D model of the M protein of Porcine Epidemic Diarrhea Virus and analysis of its immunogenic potential

Triacetyl Resveratrol Inhibits PEDV by Inducing the Early Apoptosis In Vitro

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