Emerging strategies in developing multifunctional nanomaterials for cancer nanotheranostics

Ang, Melgious Jin Yan; Chan, Siew Yin; Goh, Yi-Yiing; Luo, Zichao; Lau, Jun Wei; Liu, Xiaogang

doi:10.1016/j.addr.2021.113907

Cited by 57 publications

(34 citation statements)

References 315 publications

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“…Nonetheless, a confirmation or an analysis report can be obtained by performing laboratory tests, a biopsy and imaging procedures. Biomedical imaging facilitates not only detection but also identification of the stage of disease, in addition to prognostic measures for the patient [ 35 ]. In addition, during treatment, imaging procedures allow for real-time monitoring of the response to therapy, thereby helping to demonstrate the efficacy of the chosen strategy [ 36 ].…”

Section: Nanotheranostics: Premises and Prospectsmentioning

confidence: 99%

Advanced Optical Imaging-Guided Nanotheranostics towards Personalized Cancer Drug Delivery

2022

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Nanomedicine involves the use of nanotechnology for clinical applications and holds promise to improve treatments. Recent developments offer new hope for cancer detection, prevention and treatment; however, being a heterogenous disorder, cancer calls for a more targeted treatment approach. Personalized Medicine (PM) aims to revolutionize cancer therapy by matching the most effective treatment to individual patients. Nanotheranostics comprise a combination of therapy and diagnostic imaging incorporated in a nanosystem and are developed to fulfill the promise of PM by helping in the selection of treatments, the objective monitoring of response and the planning of follow-up therapy. Although well-established imaging techniques, such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT), are primarily used in the development of theranostics, Optical Imaging (OI) offers some advantages, such as high sensitivity, spatial and temporal resolution and less invasiveness. Additionally, it allows for multiplexing, using multi-color imaging and DNA barcoding, which further aids in the development of personalized treatments. Recent advances have also given rise to techniques permitting better penetration, opening new doors for OI-guided nanotheranostics. In this review, we describe in detail these recent advances that may be used to design and develop efficient and specific nanotheranostics for personalized cancer drug delivery.

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Section: Nanotheranostics: Premises and Prospectsmentioning

confidence: 99%

Advanced Optical Imaging-Guided Nanotheranostics towards Personalized Cancer Drug Delivery

2022

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“…These include the monosubstituted benzene ring, the 1,4 disubstituted benzene ring, and the 1,2,3 trisubstituted benzene ring, attributable to the extract of E. globulus, which in turn contains phenolic components (3Ar-(OH)n) such as borneol, carvacrol, citronellal, etc. These components react with the metal ions (precursors), generating oxidation reduction and finally achieving stabilization, due to the presence of a greater amount of other hydroxide ions (OH) Equation (1).…”

Section: Fourier Transform Infrared Spectroscopy (Ft-ir)mentioning

confidence: 99%

“…In recent years, advancement in nanotechnology research has grown exponentially. These increasingly important nanomaterials are made up of nanoparticles (NPs) smaller than 100 nanometers, giving rise to a wide field of applications in biomedicine [1][2][3][4][5], the food industry [6,7], environmental bioremediation [8][9][10][11], energy storage [12], aquaculture [13], and more. These increasing applications have generated a change of direction in research for the development of profitable and environmentally friendly technologies [14].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Superparamagnetic Iron Oxide Nanoparticles with Eucalyptus globulus Extract and Their Application in the Removal of Heavy Metals from Agricultural Soil

et al. 2022

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The green synthesis of metal oxide nanoparticles is presented as an excellent sustainable alternative for achieving nanostructures, with potential applications. This research provides important information regarding the influence of the type of solvent used in extracting organic reducing agents from E. globulus on the FeO NPs green synthesis protocol. A broad approach to characterization is presented, where UV-vis spectrophotometry suggests the presence of this type of nanoparticulate material. Likewise, the reduction mechanism was evaluated by FT-IR and the magnetic properties were evaluated by PPSM. In addition, characterizations were linked via elemental analysis (EDX), crystallographic characterization (XRD), electron microscopy (SEM/STEM), and Z potential to evaluate colloidal stability. The results show the influence of the type of solvent used for the extraction of organic reducing agents from E. globulus, and the effect on the synthesis of FeO NPs. In addition, the nanostructure material obtained showed excellent efficiency in the remediation of agricultural soil, eliminating metals such as Cr-VI, Cd, and, to a lesser extent, Pb.

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“…Besides, even in the case of complete infiltration into tumor cells, the clearance data of NPs is scarce. [125] Second, the instability of biomimetic NPs. Physicochemical properties such as size, shape, elasticity can significantly affect the delivery efficiency of NPs.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Advances in Brain Delivery Systems Based on Biomimetic Nanoparticles

Qian

Chu

2022

ChemNanoMat

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At present, therapeutics for the diseases of central nervous system (CNS) are complicated by the presence of the blood-brain barrier (BBB). The BBB maintains intracranial homeostasis and facilitates brain-body communications, but hinders the effectiveness of drug-delivery systems based on nanoparticles (NPs). Great efforts have been devoted to the imprvement of NP-based brain delivery over the past decades. In addition to chemical modifications, biomimetic technologies such as cell membranes or neurotropic viruses camouflage, immune cells or extracellular vesicles (EVs) loading are promising candidates to make NPs ideal vehicles. This review summarizes the characteristics and transport mechanisms of BBB, and the recent advances in biomimetic technologies as well as administration methods that enhance the BBB penetration and targeting capabilities of NPs.

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Emerging strategies in developing multifunctional nanomaterials for cancer nanotheranostics

Cited by 57 publications

References 315 publications

Advanced Optical Imaging-Guided Nanotheranostics towards Personalized Cancer Drug Delivery

Advanced Optical Imaging-Guided Nanotheranostics towards Personalized Cancer Drug Delivery

Green Synthesis of Superparamagnetic Iron Oxide Nanoparticles with Eucalyptus globulus Extract and Their Application in the Removal of Heavy Metals from Agricultural Soil

Advances in Brain Delivery Systems Based on Biomimetic Nanoparticles

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