Emerging therapies for neuromodulation in Parkinson's disease

Martinez-Nunez, Alfonso Enrique; Justich, Maria Belen; Okun, Michael S.; Fasano, Alfonso

doi:10.1016/j.neurot.2023.e00310

Cited by 2 publications

(2 citation statements)

References 192 publications

(218 reference statements)

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“…To test our hypothesis, we made use of intracranial brain recordings (LFP) from Stereoelectroencephalography (sEEG) leads [38], which are used in surgeries for treatment of various neurological disorders, including epilepsy [6, 39], Parkinson’s disease [7], and dystonia [4, 40, 41]. The sEEG leads were implanted into potential DBS targets, as part of the clinical evaluation for implantation of permanent DBS electrodes in deep brain regions of seven children and young adults with dystonia [4, 11, 40].…”

Section: Introductionmentioning

confidence: 99%

“…Deep brain stimulation (DBS) is a neuromodulation technique that involves implantation of depth electrodes at potential targets in the brain, through which electrical pulses are administered to modulate neuronal activity [1]. It has been shown that DBS is an effective treatment of various movement and neurological disorders [2], including Parkinson's disease [3], dystonia [4], essential tremor [5], epilepsy [6], and Alzheimer's disease [7]. Additionally, recent advancements show that DBS can be used for the treatment of psychological conditions such as obsessive compulsive disorder [8] and major depressive disorder [9].…”

Section: Introductionmentioning

confidence: 99%

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Deep brain stimulation in globus pallidus internus travels to thalamus and subthalamic nuclei along physiological pathways

Kasiri

Hillman

Hernández‐Martín

et al. 2023

Preprint

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Deep brain stimulation (DBS) is used for targeted neuromodulation in the treatment of patients with movement disorders. It is often assumed that the primary effect of DBS occurs at the site of stimulation, potentially blocking or distorting intrinsic abnormal signals. However, despite the similarity of DBS to the effects of lesions in early studies, recent work has shown that DBS leads to robust evoked potentials (EP) in multiple brain regions connected to the stimulation site. While the significance of these EPs for therapeutic outcomes is not known, it appears that the electrical effects of DBS are having at least a partial modulatory effect on downstream targets. The availability of EP recordings from DBS provides an opportunity to investigate functional connectivity between deep brain regions. An understanding of functional and structural connectivity in patients with movement disorders is critical for determining the mechanism of DBS. This study aims to examine and shed light on how electrical stimulation from DBS pulses is carried along neural pathways. We hypothesize that the pathways that transmit external electrical stimulation include the pathways that transmit intrinsic neural signals, and are more likely to travel in the direction of intrinsic signals. To test this hypothesis, we acquired intrinsic brain signals and EPs through depth electrodes in seven children with dystonia. Transfer function analysis was performed to compare the transmission of signals from external electrical stimulation, along orthodromic and antidromic pathways, with the transmission of intrinsic brain signals. The methodology described offers a tool for predicting the transmission of DBS through deep brain networks. Further studies are necessary to confirm the feasibility of detecting differences between anatomic and non-anatomic pathways.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Deep brain stimulation in globus pallidus internus travels to thalamus and subthalamic nuclei along physiological pathways

Kasiri

Hillman

Hernández‐Martín

et al. 2023

Preprint

View full text Add to dashboard Cite

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The Role of Non-Invasive Brain Modulation in Identifying Disease Biomarkers for Diagnostic and Therapeutic Purposes in Parkinsonism

Birreci,

De Riggi,

Costa

et al. 2024

Brain Sciences

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Over the past three decades, substantial advancements have occurred in non-invasive brain stimulation (NIBS). These developments encompass various non-invasive techniques aimed at modulating brain function. Among the most widely utilized methods today are transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (TES), which include direct- or alternating-current transcranial stimulation (tDCS/tACS). In addition to these established techniques, newer modalities have emerged, broadening the scope of non-invasive neuromodulation approaches available for research and clinical applications in movement disorders, particularly for Parkinson’s disease (PD) and, to a lesser extent, atypical Parkinsonism (AP). All NIBS techniques offer the opportunity to explore a wide range of neurophysiological mechanisms and exert influence over distinct brain regions implicated in the pathophysiology of Parkinsonism. This paper’s first aim is to provide a brief overview of the historical background and underlying physiological principles of primary NIBS techniques, focusing on their translational relevance. It aims to shed light on the potential identification of biomarkers for diagnostic and therapeutic purposes, by summarising available experimental data on individuals with Parkinsonism. To date, despite promising findings indicating the potential utility of NIBS techniques in Parkinsonism, their integration into clinical routine for diagnostic or therapeutic protocols remains a subject of ongoing investigation and scientific debate. In this context, this paper addresses current unsolved issues and methodological challenges concerning the use of NIBS, focusing on the importance of future research endeavours for maximizing the efficacy and relevance of NIBS strategies for individuals with Parkinsonism.

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Emerging therapies for neuromodulation in Parkinson's disease

Cited by 2 publications

References 192 publications

Deep brain stimulation in globus pallidus internus travels to thalamus and subthalamic nuclei along physiological pathways

Deep brain stimulation in globus pallidus internus travels to thalamus and subthalamic nuclei along physiological pathways

The Role of Non-Invasive Brain Modulation in Identifying Disease Biomarkers for Diagnostic and Therapeutic Purposes in Parkinsonism

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