Emerging topics in cutaneous wound repair

Abstract

The intervention strategies in various types of skin wounds include several treatment programs that depend on the identified disease. Several factors such as aging, defective nutrition, traumatism, atherosclerosis, and diabetes may contribute to the formation of a wound that has no tendency to heal due to a defective and complicated repair process. The numerous advances in the understanding of the wound‐healing process in both acute and chronic lesions have been recently described. The purpose of this paper is to describe relatively new approaches as viable alternatives to current wound‐healing therapies. The future challenges for both the best targeting and optimization of these potential treatments are also described.

Influence of Comorbidities: Neuropathy, Vasculopathy, and Diabetes on Healing Response Quality

“…56 Negative pressure wound therapy. Negative pressure wound therapy (NPWT) has emerged as an adjuvant therapy in treatment of difficult healing wounds.…”

Acellular Gelatinous Material of Human Umbilical Cord Enhances Wound Healing: A Candidate Remedy for Deficient Wound Healing

“…These steps allow for the reformation and revascularization of the skin by allowing a functional dermis and epidermis to form. About 1.5 billion people suffer from skin diseases as a consequence of both progressive aging and the lack of adequate health-care (Valacchi et al, 2012). Among these, skin lesions are highly prevalent and can be divided into acute or chronic wounds (Whitney, 2005).…”

“…Among these, skin lesions are highly prevalent and can be divided into acute or chronic wounds (Whitney, 2005). It has been reported that acute wounds generally follow trauma or inflammation and usually heal within 6 weeks (Valacchi et al, 2012). In certain circumstances, chronic wounds, also known as non-healing wounds result which do not progress through the normal wound healing steps and fail to heal within 6 weeks, this type of wound results in an open laceration of varying degrees of severity (Branski et al, 2009).…”

Shell Extracts from the Marine Bivalve Pecten maximus Regulate the Synthesis of Extracellular Matrix in Primary Cultured Human Skin Fibroblasts

“…Generally, wound healing involves sequential and overlapping processes corresponding to denaturation and necrosis of wounded tissues, inflammation, granulation tissue formation, and tissue remodelling by the restoration of physiological structure and function [31]–[32]. During the initial inflammatory phase of wound healing, fibroblasts migrate to the wound, where they synthesise and later remodel new extracellular matrix material, of which collagen is the main component [33].…”