Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery

Prasher, Parteek; Sharma, Mousmee; Mudila, Harish; Gupta, Gaurav; Sharma, Abhishek Kumar; Kumar, Deepak; Bakshi, Hamid A.; Negi, Poonam; Kapoor, Deepak; Chellappan, Dinesh Kumar; Tambuwala, Murtaza M.; Dua, Kamal

doi:10.1016/j.colcom.2020.100244

Cited by 110 publications

(43 citation statements)

References 188 publications

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“…The two most used systems of metal NPs are gold (AuNPs) and silver (AgNPs) due to their broad-spectrum activities [169]. These systems offer suitable strategies for delivering AMPs, as both counterparts are usually of low molecular weight.…”

Section: Metallic Npsmentioning

confidence: 99%

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

2020

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Bacterial infections occur when wound healing fails to reach the final stage of healing, which is usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site, which is accompanied very often by increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases. AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies that are used to combat infection and modulate the healing rate—such as polymers, scaffolds, films and wound dressings, and organic and inorganic nanoparticles—have been discussed as well. New technologies such as Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated protein (CRISPR-Cas) are taken into consideration as potential future tools for AMP delivery in skin therapy.

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Section: Metallic Npsmentioning

confidence: 99%

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

2020

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“…The two most used systems of metal NPs are gold (AuNPs) and silver (AgNPs) due to their broad-spectrum activities [140]. This system offers suitable strategies for delivering AMPs as both counterparts are usually of low molecular weight.…”

Section: Metallic Npsmentioning

confidence: 99%

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

Patrulea¹,

Borchard²,

Jordan³

2020

Preprint

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Bacterial infections occur when wound healing fails to reach the final stage of healing, usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site accompanied very often by an increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases. AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies, such as polymers, scaffolds, films and wound dressings, organic and inorganic nanoparticles, to combat infection and modulate the healing rate have been discussed as well. New technologies such as CRISPR-Cas are taken into consideration as potential future tools for AMP delivery in skin therapy.

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“…Therefore, people are actively developing antibiotics‐free strategies or low‐dose precise drug‐delivery treatment strategies. [ 14,15 ] Antibacterial biomaterials have been emerging as a potential substitute of antibiotics for the treatment of bacterial infectious diseases. [ 16 ] Antibacterial materials have been widely used in the treatment and repair of infectious skin wounds, [ 17 ] infections related to the reconstruction of infectious bone defect tissues, [ 18 ] as well as the treatment of other infectious diseases, such as bacterial pneumonia, [ 19 ] prevention of bacterial infections of bone implants, [ 20 ] and the surface antibacterial research of materials.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Hybrid Hydrogels

Cao

Luo

et al. 2020

Macromolecular Bioscience

134

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Bacterial infectious diseases and bacterial‐infected environments have been threatening the health of human beings all over the world. In view of the increased bacteria resistance caused by overuse or improper use of antibiotics, antibacterial biomaterials are developed as the substitutes for antibiotics in some cases. Among them, antibacterial hydrogels are attracting more and more attention due to easy preparation process and diversity of structures by changing their chemical cross‐linkers via covalent bonds or noncovalent physical interactions, which can endow them with various specific functions such as high toughness and stretchability, injectability, self‐healing, tissue adhesiveness and rapid hemostasis, easy loading and controlled drug release, superior biocompatibility and antioxidation as well as good conductivity. In this review, the recent progress of antibacterial hydrogel including the fabrication methodologies, interior structures, performances, antibacterial mechanisms, and applications of various antibacterial hydrogels is summarized. According to the bacteria‐killing modes of hydrogels, several representative hydrogels such as silver nanoparticles‐based hydrogel, photoresponsive hydrogel including photothermal and photocatalytic, self‐bacteria‐killing hydrogel such as inherent antibacterial peptides and cationic polymers, and antibiotics‐loading hydrogel are focused on. Furthermore, current challenges of antibacterial hydrogels are discussed and future perspectives in this field are also proposed.

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Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery

Cited by 110 publications

References 188 publications

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

Antibacterial Hybrid Hydrogels

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