Emerging Trends in the Industrial Production of Chemical Products by Microorganisms

Paul, Pandeeti Emmanuel Vijay; Sangeetha, V.; Deepika, Routhu Gyana

doi:10.1016/b978-0-12-816328-3.00009-x

Cited by 44 publications

(22 citation statements)

References 88 publications

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“…And in a non-covalent bond, a cofactor is attached to the enzyme it is also called as a coenzyme. Cofactors and coenzymes are used in the catalysis of enzymes for organic synthesis (Kataoka et al, 2003;Paul et al, 2019). Application Except for hydrolases, all enzyme classes manifest cofactor reliance.…”

Section: Cofactor and Coenzymesmentioning

confidence: 99%

Enzyme Biocatalysis in Organic Synthesis

Yaseen

Siddique

Idrees

et al. 2021

Biol Clin Sci Res J

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The factor that makes enzyme biocatalysts for organic synthesis both fascinating and challenging from a scientific standpoint is the field's higher interdisciplinarity, and which necessitates expertise from a wide range of disciplines, including microbiology, organic synthesis, molecular biology, genetics, and reaction engineering. Enzymes can now carry out a wide variety of organic reactions, including hydrolytic reactions, redox reactions, and C-C bond formations, with higher performance. Enzyme catalysis has also evolved into a widely used manufacturing technology in the chemical industry, especially in the fields of fine organic chemicals and pharmaceuticals. More advances in molecular modeling for enzyme-catalysis syntheses are expected, allowing for a greater number of biocatalytic techniques based on the enzymes that have been optimized or engineered by rationalized protein engineering. The organic chemists mostly have successfully used these custom-made biocatalysts (the isolated pure enzymes, the recombinant genetically modified microorganisms, also known as the designer cells), an important milestone in the enzyme catalysis process in organic synthesis is into generally accepted synthetic technology for academia as well as industries.

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Section: Cofactor and Coenzymesmentioning

confidence: 99%

Enzyme Biocatalysis in Organic Synthesis

Yaseen

Siddique

Idrees

et al. 2021

Biol Clin Sci Res J

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“…One of the major applications of oxidoreductase is a pharmaceutical synthesis of 3,4-dihydroxylphenyl alanine (DOPA), which is employed in the treatment of Parkinson's disease and the industrial process that synthesizes DOPA make use of the oxidoreductase polyphenol oxidase [65]. It has been reported that the enantioselective reduction of C-4-substituted 3,5-dixocarboxylates can be carried out by using alcohol dehydrogenase from Lactobacillus brevis (LBADH) over-expressed in E. coli [66].…”

Section: Oxidoreductase-based Approaches For Synthesis Of Polymers Anmentioning

confidence: 99%

Applications of Oxidoreductases

Gogoi¹

2021

Oxidoreductase

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Oxidoreductases comprise of a large group of enzymes catalyzing the transfer of electrons from an electron donor to an electron acceptor molecule, commonly taking nicotinamide adenine dinucleotide phosphate (NADP) or nicotinamide adenine dinucleotide (NAD) as cofactors. Research on the potential applications of oxidoreductases on the growth of oxidoreductase-based diagnostic tests and better biosensors, in the design of inventive systems for crucial coenzymes regeneration, and in the creation of oxidoreductase-based approaches for synthesis of polymers and oxyfunctionalized organic substrates have made great progress. This chapter focuses on biocatalytic applications of oxidoreductases, since many chemical and biochemical transformations involve oxidation/reduction processes, developing practical applications of oxidoreductases has long been a significant target in biotechnology. Oxidoreductases are appropriate catalysts owing to their biodegradability, specificity and efficiency and may be employed as improved biocatalysts to substitute the toxic/expensive chemicals, save on energy/resources consumption, generate novel functionalities, or reduce complicated impacts on environment.

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“…Generally, transferases do not play a major role in industrial processes, despite their catalytic function of transferring a non-hydrogen moiety between a pair of substrates ( Singh et al, 2016 ; Paul et al, 2019 ). However, one transferase subgroup, DNA polymerases, is widely used for DNA manipulation, sequencing, labeling, mutagenesis, and other purposes ( Ishino and Ishino, 2014 ).…”

Section: Enzymes From the Red Sea And Their Potential Biotechnological Applicationmentioning

confidence: 99%

Novel Enzymes From the Red Sea Brine Pools: Current State and Potential

et al. 2021

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The Red Sea is a marine environment with unique chemical characteristics and physical topographies. Among the various habitats offered by the Red Sea, the deep-sea brine pools are the most extreme in terms of salinity, temperature and metal contents. Nonetheless, the brine pools host rich polyextremophilic bacterial and archaeal communities. These microbial communities are promising sources for various classes of enzymes adapted to harsh environments – extremozymes. Extremozymes are emerging as novel biocatalysts for biotechnological applications due to their ability to perform catalytic reactions under harsh biophysical conditions, such as those used in many industrial processes. In this review, we provide an overview of the extremozymes from different Red Sea brine pools and discuss the overall biotechnological potential of the Red Sea proteome.

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Emerging Trends in the Industrial Production of Chemical Products by Microorganisms

Cited by 44 publications

References 88 publications

Enzyme Biocatalysis in Organic Synthesis

Enzyme Biocatalysis in Organic Synthesis

Applications of Oxidoreductases

Novel Enzymes From the Red Sea Brine Pools: Current State and Potential

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