Emerging Unconventional Therapies for Alopecia Areata

Mesinkovska, Natasha Atanaskova

doi:10.1016/j.jisp.2017.10.012

Cited by 11 publications

(10 citation statements)

References 9 publications

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“…6 Recalcitrant alopecia areata is difficult to treat and current therapeutic modalities are of limited effectiveness. 1,6 Data about the effectiveness of cryotherapy in treating recalcitrant alopecia areata is limited. 14 We carried out this study to evaluate the safety and efficacy of liquid…”

Section: Discussionmentioning

confidence: 99%

“…Alopecia areata is a common, autoimmune, stressful disorder characterized by nonscarring hair loss which takes many forms ranging from well‐defined patches to diffuse or total hair loss 6 . Recalcitrant alopecia areata is difficult to treat and current therapeutic modalities are of limited effectiveness 1,6 . Data about the effectiveness of cryotherapy in treating recalcitrant alopecia areata is limited 14 .…”

Section: Discussionmentioning

confidence: 99%

“…Alopecia areata (AA) is an immune‐mediated disease characterized by nonscarring hair loss involving the scalp and/or body 1,2 . Both sexes are equally affected 3 and 60% of the patients are usually affected by alopecia patch before 20 years of age 4 …”

Section: Introductionmentioning

confidence: 99%

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Different freezing time of superficial liquid nitrogen cryotherapy in treatment of recalcitrant alopecia areata: Randomized clinical trial

Motaleb

Sayed

2020

Dermatologic Therapy

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Recalcitrant alopecia areata is not uncommon in clinical practice and some patients experienced either treatment failure or recurrence with most of the conventional therapies. Several studies have evaluated the efficacy of cryotherapy in the treatment of alopecia areata with controversial results. This study aimed to optimize the ideal timing of liquid nitrogen cryospraying to achieve the most favorable results. A total of 75 patients with recalcitrant alopecia areata were treated with superficial cryotherapy, two freeze‐thaw cycles, each consisted of 3 to 5, 8 to 10, and 13 to 15 seconds in group A, B, and C, respectively. Good to moderate improvement was achieved in 65.2%, 76%, and 76.2% in groups A, B, and C, respectively, with no statistically significant difference. However, the mean percentage of improvement was significantly higher in group B and C compared to group A (P‐value < .05 for each). Superficial liquid nitrogen cryotherapy is an effective therapeutic modality for recalcitrant alopecia areata. Moreover, using 8 to 10 seconds dual freeze‐thaw cycles is the optimum timing.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Different freezing time of superficial liquid nitrogen cryotherapy in treatment of recalcitrant alopecia areata: Randomized clinical trial

Motaleb

Sayed

2020

Dermatologic Therapy

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“…Triamcinolone acetonide (Kenacort) is a steroid solution that has been used as a treatment for AA for over 50 years. [ 3 ] It is administered via injection into the scalp and appears to have some efficacy for patients with mild-to-moderate AA. Intralesional corticosteroids, particularly triamcinolone acetonide, remain first-line therapy in adults with limited, patchy AA.…”

Section: Introductionmentioning

confidence: 99%

A prospective study to compare the efficacy of cryotherapy versus intralesional steroid in alopecia areata

Sardana¹,

Goyal²,

Kushwaha³

et al. 2022

J Cutan Aesthet Surg

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Background: Alopecia areata (AA) is an autoimmune disease that results in the loss of hair on the scalp and elsewhere on the body. The present study was conducted to compare the intralesional steroid and cryotherapy in the treatment of AA. Materials and Methods: The present clinical study was conducted in the Department of Dermatology, Venereology, and Leprology, Muzaffarnagar Medical College. The simple random sampling technique was used for randomly dividing the subjects into two groups: group I (local cryotherapy) and group II (intralesional corticosteroid). Results: A positive response was significantly more among the intralesional steroid group (86.0%) when compared with the cryotherapy group (62.0%). There was a significant difference in relapse between intralesional steroid group (22.0%) and cryotherapy group (16.0%). An excellent response was significantly more among the intralesional steroid group (44.0%) when compared with the cryotherapy group (18.0%). Poor response was significantly more among the cryotherapy group (18.0%), compared with the intralesional steroid group (0.0%). The mean pre-treatment, post-treatment, and the change from pre- to post-treatment Severity of Alopecia Tool [SALT] were compared between cryotherapy and intralesional steroid groups using the unpaired t -test. The mean pre-treatment, post-treatment, and the change from pre- to post-treatment SALT were significantly more among the intralesional steroid group when compared with the cryotherapy group. Conclusion: The authors found that superficial cryotherapy could be a meaningful adjuvant treatment option for AA patients. There was a significantly less relapse rate with cryotherapy. Among the currently available topical modalities for the treatment of AA, the best response was to the intralesional steroids followed by cryotherapy.

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“…2 Alopecia areata is a prevalent autoimmune skin disease with no cure or indicated treatment options. 3 In the absence of an approved treatment, some patients are eager to try unconventional therapies, despite the very limited research evaluating their safety and efficacy. Recently emerging such unconventional therapies for alopecia areata discussed include antihistamines, cryotherapy and low-dose naltrexone.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Efficacy of Liquid Nitrogen Cryotherapy for Treatment of Alopecia Areata

Aslam¹,

Ilyas²,

Kaleem³

et al. 2022

PJMHS

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Objective: To assess the therapeutic efficacy of liquid nitrogen cryotherapy for treatment of alopecia areata. Study Design: Descriptive Case Series. Place and Duration of Study: Department of Dermatology at Mayo Hospital, Lahore from 15-10-2020 to 14-04-2021. Methodology: A total of 95 patients were included in the study. A photograph was obtained at baseline. Then, patients were treated with superficial liquid nitrogen cryotherapy spray once weekly for 6 weeks. A cryogun was used to spray the lesion with liquid nitrogen for 2–3 s till the appearance of mild frost. After the frozen area was thawed (3–5 s), a second spray was done in the same manner. After 6 weeks, session was stopped and patients were followed-up at 3 months and 6 months. Results: Patients ranged between 16-70 years of age with mean age of 29.5±11.9 years. Out of 95 patients, 43 (45.3%) were male while 52 (54.7%) were female. Mean duration of disease was 9.8±4.9 months. Therapeutic efficacy of liquid nitrogen cryotherapy was found to be significant in 26 patients (27.4%). Stratification for age, gender and duration of disease was carried and no association was found (p >0.05). Conclusion: In conclusion cryotherapy with liquid nitrogen is a therapeutic option with a good treatment outcome. It has the privilege of being a simple, convenient, short-term, and office-based technique. Key Words: Alopecia Areata, Liquid Nitrogen Cryotherapy, Treatment.

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Emerging Unconventional Therapies for Alopecia Areata

Cited by 11 publications

References 9 publications

Different freezing time of superficial liquid nitrogen cryotherapy in treatment of recalcitrant alopecia areata: Randomized clinical trial

Different freezing time of superficial liquid nitrogen cryotherapy in treatment of recalcitrant alopecia areata: Randomized clinical trial

A prospective study to compare the efficacy of cryotherapy versus intralesional steroid in alopecia areata

Therapeutic Efficacy of Liquid Nitrogen Cryotherapy for Treatment of Alopecia Areata

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