Emerging uses of PLA–PEG copolymer in cancer drug delivery

Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges

“…Synthetic homopolymers and copolymers can be created by starting with their corresponding monomers, resulting in various chemical structures and application areas. Synthetic polymers give therapeutic substances continuously for an extended period 42 while natural polymers are restricted to organic solvents that release pharmaceuticals quickly.…”

Smart PEG-Block-PLA/PLA Nanosystems: Impact of the Characteristics of the Polymer Blend on the Redox Responsiveness

“…mPEG- block -PLA-based nanocarriers have already demonstrated their interest in the encapsulation of nucleic acids, pharmaceutical or cosmetic active ingredients [ 7 , 8 , 9 , 10 , 11 ]. In the formulation process of NCs, many parameters may cause crucial changes in the physi-co-chemical characteristics such as morphology, size and drug encapsulation efficiency (EE) [ 12 , 13 , 14 , 15 ].…”

Lentinan-laden microspheres reprogram the tumor microenvironment and improve anti-PD-L1 efficacy

“…One potential drug delivery system is the use of polymers, which ensure the controlled delivery of hydrophilic and hydrophobic therapeutics in a stable manner over a prolonged period. Polylactic acid (PLA) is an effective FDA-approved amphiphilic polymer; 8 it is a biocompatible and biodegradable polymer matrix which has versatile drug delivery applications and can be efficiently loaded with hydrophilic drugs (e.g., LNT). 9 As demonstrated in our and other studies, [10][11][12] PLA-based microspheres with controlled degradation rates could be tuned via tune the physiochemical properties (e.g., specific molecular weight or structure), enabling the release of active pharmaceutical ingredients to achieve the desired therapeutic response.…”

“…One potential drug delivery system is the use of polymers, which ensure the controlled delivery of hydrophilic and hydrophobic therapeutics in a stable manner over a prolonged period. Polylactic acid (PLA) is an effective FDA-approved amphiphilic polymer; 8 it is a biocompatible and biodegradable polymer matrix which has versatile drug delivery applications and can be efficiently loaded with hydrophilic drugs ( e.g. , LNT).…”