Emily L.

Structural Enzymology of Polyketide Synthase: The Structure–Sequence–Function Correlation

“…Sections 1.08. 7,9 However, doxorubicin and mithramycin are produced by cyclization at C7-C12 and C9-C14, respectively. 2.…”

“…15 The modular type I PKSs are huge, multimodular complexes involved in the biosynthesis of macrolides such as erythromycin, 16 with each module containing multiple domains that are typically used only once in an 'assembly line' fashion. In the past decade, the structures of type II PKS enzymes responsible for chain Figure 1 Structural diversity of polyketide natural products (1)(2)(3)(4)(5)(6)(7) versus palmitic acid (8). Finally, type III PKSs from plants consist of a single protein that catalyzes a finite number of chain elongations using coenzyme A (CoA)-bound substrates.…”