Structural Enzymology of Polyketide Synthase: The Structure–Sequence–Function Correlation

Korman, Tyler P.; Ames, Brian D.; Tsai, Shiou‐Chuan

doi:10.1016/b978-008045382-8.00020-4

Cited by 12 publications

(4 citation statements)

References 132 publications

(106 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Zhang and Stephanopoulos [ 22 ], “The phenylpropanoids are a family of organic compounds with an aromatic ring and a three-carbon propene tail and are synthesized by plants from the amino acids phenylalanine and tyrosine” [ 23 ]. Regarding polyketides, Korman et al says: “Polyketides are a large class of structurally diverse, acetate derived natural products that exhibit a wide range of bioactivities.” [ 24 ]. As such, phenylpropanoids and polyketides are organic compounds that are synthesized either from the amino acid phenylalanine (phenylpropanoids) or the decarboxylative condensation of malonyl-CoA (polyketides).…”

Section: Methods and Implementationmentioning

confidence: 99%

DrugTax: package for drug taxonomy identification and explainable feature extraction

2022

View full text Add to dashboard Cite

DrugTax is an easy-to-use Python package for small molecule detailed characterization. It extends a previously explored chemical taxonomy making it ready-to-use in any Artificial Intelligence approach. DrugTax leverages small molecule representations as input in one of their most accessible and simple forms (SMILES) and allows the simultaneously extraction of taxonomy information and key features for big data algorithm deployment. In addition, it delivers a set of tools for bulk analysis and visualization that can also be used for chemical space representation and molecule similarity assessment. DrugTax is a valuable tool for chemoinformatic processing and can be easily integrated in drug discovery pipelines. DrugTax can be effortlessly installed via PyPI (https://pypi.org/project/DrugTax/) or GitHub (https://github.com/MoreiraLAB/DrugTax). Graphical Abstract

show abstract

Section: Methods and Implementationmentioning

confidence: 99%

DrugTax: package for drug taxonomy identification and explainable feature extraction

2022

View full text Add to dashboard Cite

show abstract

“…Polyketides are a large group of natural metabolites containing multiple β-hydroxyketone or β-hydroxyaldehyde groups, produced by diverse enzymatic complexes called polyketide synthases (PKSs). Polyketides are structurally diverse and are synthesised from coenzyme-A fatty esters derived from acetate or other short-chain fatty acids, such as propionate or butyrate, and have been found to exhibit a wide range of bioactivities [ 99 ]. Several antimicrobial polyketides isolated from endophytes have been reported in the literature, some examples of which are described below, structures of which are shown in Figure 5 .…”

Section: Antimicrobial Potential Of Endophytic Fungimentioning

confidence: 99%

Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds

et al. 2022

View full text Add to dashboard Cite

Over the last few decades, many of the existing drugs used to treat infectious diseases have become increasingly ineffective due to the global emergence of antimicrobial resistance (AMR). As such, there is a constant demand to find new, effective compounds that could help to alleviate some of this pressure. Endophytic fungi have captured the attention of many researchers in this field, as they have displayed a vast ability to produce novel bioactive compounds, many of which possess wide-ranging antimicrobial activities. However, while highly promising, research in this area is still in its infancy. Endophytes inhabit the healthy tissues of plants asymptomatically, resulting in a mutualistic symbiosis in which the endophytes produce a plethora of bioactive compounds that support the fitness of the host plant. These compounds display great chemical diversity, representing structural groups, such as aliphatic compounds, alkaloids, peptides, phenolics, polyketides and terpenoids. In this review, the significant antimicrobial potential of endophytic fungi is detailed, highlighting their ability to produce novel and diverse antimicrobial compounds active against human, plant and marine pathogens. In doing so, it also highlights the significant contributions that endophytic fungi can make in our battle against AMR, thus providing the motivation to increase efforts in the search for new and effective antimicrobial drugs.

show abstract

“…The biosynthesis of aromatic polyketides is usually accomplished by the type II polyketide synthases (PKSs), which produce highly diverse polyketide chains by sequential condensation of the starter units with extender units, followed by reduction, cyclization, aromatization and tailoring reactions to yield a more or less planar aromatic core that contain several annulated rings [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Biological evaluation and spectral characterization of a novel tetracenomycin X congener

et al. 2022

View full text Add to dashboard Cite

Structural Enzymology of Polyketide Synthase: The Structure–Sequence–Function Correlation

Cited by 12 publications

References 132 publications

DrugTax: package for drug taxonomy identification and explainable feature extraction

DrugTax: package for drug taxonomy identification and explainable feature extraction

Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds

Biological evaluation and spectral characterization of a novel tetracenomycin X congener

Contact Info

Product

Resources

About