Pollutants discharged from irrational energy consumption pose a serious threat to urban ecological security. The Western Taiwan Straits Economic Zone is an important part of China’s coastal economy. With the rapid development of the economy in this area, the atmospheric environmental pollution problem, caused by energy consumption, has become increasingly serious. Therefore, the study of the environmental impact assessment of air pollution in the Western Taiwan Straits Economic Zone has reference value to prevent ecological risks. This paper constructed a regional-scale environmental impact assessment model that includes pollution sources, pollution stress, and evaluation results, and evaluated the environmental impact of SO2, NO2, CO, PM10, and PM2.5 from three perspectives: regional integration, different energy consumption sectors, and different cities. The results showed that the regional environmental impact level of the research area was high, and the main pollutants transformed from SO2 to NO2, PM10, and PM2.5 from 2008 to 2016. According to the results of different sectors, the transportation sector contributes the most to NO2 and remains unchanged, and the industrial sector contributes the most to SO2, PM10, and PM2.5. Combined with the research results of different cities, cities concentrated in the coastal areas contribute more pollution than other cities do.