Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle

Cao, Yanni; Chang, Shufang; Dong, Jie; Zhu, Shirley; Zheng, Xiaoying; Li, Juan; Long, Rodney; Zhou, Yifei; Cui, Jianyu; Zhang, Ye

doi:10.1016/j.ejphar.2016.03.049

Cited by 24 publications

(15 citation statements)

References 26 publications

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“…It may be due to the higher milk fat in the RES treatment group. Previous studies have shown that higher fat intake of piglets was contributed to increase the FATP1 mRNA level of fatty tissue in piglets (Cao et al, ). FATP1 has a role in regulating fat accumulation and involved in fatty acid uptake and triglyceride synthesis (García‐Martínez et al, ).…”

Section: Discussionmentioning

confidence: 95%

Effects of dietary resveratrol supplementation during gestation and lactation of sows on milk composition of sows and fat metabolism of sucking piglets

Sun

Meng

Luo

et al. 2019

Animal Physiology Nutrition

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The purpose of this article was to investigate the effects of dietary resveratrol supplementation during gestation and lactation of sows on the milk composition of sows and the fat metabolism of sucking piglets. Forty sows were allotted to two experimental treatment groups that included the following: (a) control sows (CON treatment, n = 20) fed with a corn–soybean meal control diet and (b) treatment sows (RES treatment, n = 20) fed with a control diet with addition of 300 mg/kg resveratrol. The results showed that the content of lactose in the colostrum was increased (p < 0.05) and the content of fat in 21‐day milk was increased (p < 0.05) by dietary resveratrol supplementation. In the RES treatment group, the concentrations of high‐density lipoprotein‐cholesterol (HDL‐C), low‐density lipoprotein‐cholesterol (LDL‐C), lipase activity and insulin (INS) in plasma of sucking piglets were increased (p < 0.05). In the adipose tissue, the enzyme activities of hormone‐sensitive lipase (HSL), acetyl‐CoA carboxylase (ACC) and lipoprotein lipase (LPL) increased significantly by RES treatment (p < 0.05), and the mRNA levels of acetyl coenzyme A‐alpha (ACCα), LPL, fatty acid transport protein (FATP1) and CCAAT–enhancer‐binding protein gene (C/EBPα) were higher in the RES treatment group (p < 0.05). In conclusion, resveratrol supplementation on gestational and lactating sows improved the content of lactose in the colostrum and the content of fat in milk at day 21 of lactation. In addition, resveratrol supplementation on sows increased HDL and LDL in the plasma of piglets. In piglet adipose tissue, the enzyme activity and mRNA level related to lipolysis, fatty acid uptake from circulating triacylglycerols and lipogenesis are partially improved by resveratrol supplementation on sows. These aspects affect fat metabolism in piglets.

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Section: Discussionmentioning

confidence: 95%

Effects of dietary resveratrol supplementation during gestation and lactation of sows on milk composition of sows and fat metabolism of sucking piglets

Sun

Meng

Luo

et al. 2019

Animal Physiology Nutrition

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“… 21 22 It has been proved that sugar intake is associated with an increased risk of diabetes, 23 and too much fat has also been shown to be an important contributor to the development of obesity, insulin resistance and diabetes. 24 Thus, dietary modification is crucial for the prevention and management of pre-existing T2DM. It is therefore necessary for individuals with pre-diabetes who pay no attention to diet and eat high-fat and salty food to change their lifestyle.…”

Section: Discussionmentioning

confidence: 99%

Diabetes-related behaviours among elderly people with pre-diabetes in rural communities of Hunan, China: a cross-sectional study

Luo¹,

Zhang²,

Hu³

et al. 2018

BMJ Open

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ObjectiveTo explore diabetes-related behaviours and their influencing factors among elderly individuals with pre-diabetes in rural areas of China.Design, setting and participantsA cross-sectional survey was conducted among elderly individuals (≥60 years) in rural communities in Yiyang City of China. Multistaged cluster random sampling was carried out to select 42 areas, and interviews were conducted among 434 elderly individuals with pre-diabetes (fasting plasma glucose 6.1–7.0 mmol/L and/or 2-hour post-glucose load of 7.8–11.1 mmol/L) using questionnaires on diabetes-related behaviours. The diabetes-related behaviours included eight categories: average daily sedentary time; frequency of physical activities per week; regular or irregular diet; whether paying attention to diet control or not; daily dietary preferences; frequency of physical examinations per year; current smoking status; and current consumption of alcohol. Each of the risky behaviours was scored −1 and each of the healthy behaviours was scored +1. Each individual’s score of diabetes-related behaviours was the sum of the score for all behaviours.Main outcome measuresParticipants were asked about general information (age, gender, marital status, history of hyperglycaemia, family history of diabetes mellitus, presence of other diseases, body mass index, waist-to-hip ratio and education) and their diabetes-related behaviours. Multivariate linear regression analysis was performed to identify the risk factors for diabetes-related behaviour among elderly individuals with pre-diabetes.ResultsThe average score of diabetes-related behaviours of elderly individuals with pre-diabetes in rural China was 2.7. The prevalences of risky diabetes-related behaviours were as follows: <1 physical examination per year (57.6%), insufficient physical activities (55.3%), lack of attention paid to diet control (51.4%), high-salt and high-fat diets (41.0%), sedentary lifestyle (35.9%), smoking (22.8%), regular alcohol uptake (15.0%) and irregular diet (3.9%). Gender and a history of hyperglycaemia were found to be influencing factors of the diabetes-related behaviour score.ConclusionsThe prevalence of risky diabetes-related behaviours was high among pre-diabetic elderly individuals in rural China. More effort should be made to promote the prevention and control of diabetes in rural China. Future studies should be undertaken on diabetes prevention strategies tailored specially for this population.Trial registration numberChiCTR-IOR-15007033; Results.

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“…An increasing number of studies have reported that an excessive high‐fat diet caused obesity and contribute to the occurrence of IR . Dietary consumption of RS instead of regular starch is considered as a potential approach to reduce IR, in terms of its low calorie content.…”

Section: Discussionmentioning

confidence: 99%

Effect of single or combined administration of resistant starch and chitosan oligosaccharides on insulin resistance in rats fed with a high‐fat diet

Wang

Shang

et al. 2016

Starch Stärke

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Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle

Cited by 24 publications

References 26 publications

Effects of dietary resveratrol supplementation during gestation and lactation of sows on milk composition of sows and fat metabolism of sucking piglets

Effects of dietary resveratrol supplementation during gestation and lactation of sows on milk composition of sows and fat metabolism of sucking piglets

Diabetes-related behaviours among elderly people with pre-diabetes in rural communities of Hunan, China: a cross-sectional study

Effect of single or combined administration of resistant starch and chitosan oligosaccharides on insulin resistance in rats fed with a high‐fat diet

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