2017
DOI: 10.1159/000478754
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Emodin: One Main Ingredient of Shufeng Jiedu Capsule Reverses Chemoresistance of Lung Cancer Cells Through Inhibition of EMT

Abstract: Background: Chemoresistance has become a an important worldwide problem to cancer treatment. Understanding the mechanism of drug resistance is the key to solve this problem and improve the survival of the patient. Doxorubicin and its analogues are widely used as antitumor drugs but many doxorubicin resistant cases have been identified in recent years. Doxorubicin (Dox) resistance is a very serious phenomenon in lung cancer treatment. As we could show previously, Shufeng Jiedu Capsule (SFJDC) can effectively re… Show more

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Cited by 26 publications
(16 citation statements)
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“…These results revealed that FKBP51 promotes migration and invasion through NF-κB pathway-dependent EMT. This result is consistent with previous findings, for example Ying et al ( 42 ) demonstrated that induced EMT was accompanied by nuclear translocation of NF-κB in lung cancer. Lv et al ( 43 ) revealed that twist1 regulates EMT via the NF-κB pathway in PTC.…”
Section: Discussionsupporting
confidence: 94%
“…These results revealed that FKBP51 promotes migration and invasion through NF-κB pathway-dependent EMT. This result is consistent with previous findings, for example Ying et al ( 42 ) demonstrated that induced EMT was accompanied by nuclear translocation of NF-κB in lung cancer. Lv et al ( 43 ) revealed that twist1 regulates EMT via the NF-κB pathway in PTC.…”
Section: Discussionsupporting
confidence: 94%
“…Experiment protocol was performed as described previously [27,28]. Total RNA samples were extracted with TriPure Isolation Reagent (Roche, Switzerland) and cDNA prepared from 1 mg of total RNA using the SuperScript III System (Invitrogen Life Technologies).…”
Section: Reverse Transcriptase Polymerase Chain Reaction (Rt-pcr)mentioning
confidence: 99%
“…SJC is widely used as an antipyretic and anti-inflammatory medicine [6,[28][29][30], especially for the treatment of acute upper respiratory tract infections [31], which may involve the ERK signaling pathway. Although it has shown significant effects for the treatment of sore throat, headache, nasal congestion, flow turbidity, and pulmonary embolism, most other studies on SJC have focused on single chemical composition analysis.…”
Section: Discussionmentioning
confidence: 99%