Emotion-Specific Processing Deficit in Focal Brain-Damaged Patients

Mandal, Manas K.; Mohanty, Aprajita; Pandey, Rakesh; Mohanty, Suman

doi:10.3109/00207459608987253

Cited by 32 publications

(13 citation statements)

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“…According to the right hemisphere hypothesis of emotion, the right hemisphere of the brain is specialized for emotional and the left for cognitive processes [2], [3]. This hypothesis is supported by findings from behavioral [2], [4] and lesion studies [5] although conflicting findings have been reported [6], [7], [8].…”

Section: Introductionmentioning

confidence: 86%

Hemispheric Asymmetry for Affective Stimulus Processing in Healthy Subjects–A fMRI Study

et al. 2012

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BackgroundWhile hemispheric specialization of language processing is well established, lateralization of emotion processing is still under debate. Several conflicting hypotheses have been proposed, including right hemisphere hypothesis, valence asymmetry hypothesis and region-specific lateralization hypothesis. However, experimental evidence for these hypotheses remains inconclusive, partly because direct comparisons between hemispheres are scarce.MethodsThe present fMRI study systematically investigated functional lateralization during affective stimulus processing in 36 healthy participants. We normalized our functional data on a symmetrical template to avoid confounding effects of anatomical asymmetries. Direct comparison of BOLD responses between hemispheres was accomplished taking two approaches: a hypothesis-driven region of interest analysis focusing on brain areas most frequently reported in earlier neuroimaging studies of emotion; and an exploratory whole volume analysis contrasting non-flipped with flipped functional data using paired t-test.ResultsThe region of interest analysis revealed lateralization towards the left in the medial prefrontal cortex (BA 10) during positive stimulus processing; while negative stimulus processing was lateralized towards the right in the dorsolateral prefrontal cortex (BA 9 & 46) and towards the left in the amygdala and uncus. The whole brain analysis yielded similar results and, in addition, revealed lateralization towards the right in the premotor cortex (BA 6) and the temporo-occipital junction (BA 19 & 37) during positive stimulus processing; while negative stimulus processing showed lateralization towards the right in the temporo-parietal junction (BA 37,39,42) and towards the left in the middle temporal gyrus (BA 21).ConclusionOur data suggests region-specific functional lateralization of emotion processing. Findings show valence asymmetry for prefrontal cortical areas and left-lateralized negative stimulus processing in subcortical areas, in particular, amygdala and uncus.

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Section: Introductionmentioning

confidence: 86%

Hemispheric Asymmetry for Affective Stimulus Processing in Healthy Subjects–A fMRI Study

et al. 2012

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“…C. Borod, et al, 1998; J.C. Borod, Koff, Perlman, & Nicholas, 1986;Charbonneau, Scherzer, Aspirot, & Cohen, 2003;Zgaljardic, Borod, & Sliwinski, 2002). However, several studies have also indicated that left hemisphere lesions can sometimes result in impaired EP (Braun, Traue, Frisch, Deighton, & Kessler, 2005;Mandal, Mohanty, Pandey, & Mohanty, 1996). For ToM, some previous studies have reported that right hemisphere damage impairs (cognitive) ToM more than left hemisphere damage (Griffin, et al, 2006;F.…”

Section: Lesion Study Data On the Relationship Between Emotion Percepmentioning

confidence: 99%

The overlapping relationship between emotion perception and theory of mind

2015

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Socio-cognitive skills are crucial for successful interpersonal interactions. Two particularly important socio-cognitive processes are emotion perception (EP) and theory of mind (ToM), but agreement is lacking on terminology and conceptual links between these constructs. Here we seek to clarify the relationship between the two at multiple levels, from concept to neuroanatomy. EP is often regarded as a low-level perceptual process necessary to decode affective cues, while ToM is usually seen as a higher-level cognitive process involving mental state deduction. In information processing models, EP tends to precede ToM. At the neuroanatomical level, lesion study data suggest that EP and ToM are both right-hemisphere based, but there is also evidence that ToM requires temporal-cingulate networks, whereas EP requires partially separable regions linked to distinct emotions. Common regions identified in fMRI studies of EP and ToM have included medial prefrontal cortex and temporal lobe areas, but differences emerge depending on the perceptual, cognitive and emotional demands of the EP and ToM tasks. For the future, clarity of definition of EP and ToM will be paramount to produce distinct task manipulations and inform models of sociocognitive processing.

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“…In its earliest form, this hypothesis highlighted a critical role for the RH in all aspects of emotion processing, including both positive and negative emotions. For example, behavioral studies in humans have shown that emotions are expressed more intensely on the left side of the face (Sackeim & Gur, 1978) and that RH damage has been associated with impaired recognition of facial expressions of emotion (Mandal, Mohanty, Pandey, & Mohanty, 1996). It should be noted that not all studies have demonstrated a reliable emotion-RH link (Mandal, Asthana, Tandon, & Asthana, 1992), and interested readers are referred to the following source for further reading in this area (Borod, Zgaljardic, Tabert, & Koff, 2001).…”

Section: Single-system Models Of Emotionmentioning

confidence: 99%